Change in Pericardial Fat Volume and Cardiovascular Risk Factors in a General Population of Japanese Men

Miyazawa, Itsuko; Kadowaki, Sayaka; Fujiyoshi, Akira; Hisamatsu, Takashi; Kadota, Aya; Arima, Hisatomi; Budoff, Matthew J.; Murata, Kiyoshi; Miura, Katsuyuki; Maegawa, Hiroshi; Ueshima, Hirotsugu

doi:10.1253/circj.cj-18-0153

Cited by 12 publications

(10 citation statements)

References 44 publications

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“…In a community cohort of 623 asymptomatic Japanese men aged 40-79 years, serial cardiac CT at 4.7 years mean follow up demonstrated a significant increase in EAT volume 5 . The only clinical risk factor associated with change in EATv was current smoking.…”

Section: Discussionmentioning

confidence: 95%

“…However, most studies are cross-sectional in nature and the natural history of EAT is not well described. The few published studies are limited to small cohorts of either asymptomatic patients undergoing cardiac screening 4,5 , or elevated-risk patients either after an acute coronary syndrome, or with the presence of high risk coronary plaque characteristics 6 . EAT is best evaluated by volumetric measurement on computed tomography (EAT) 7 , a non-invasive radiography modality designed for use in low-intermediate risk symptomatic patients.…”

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confidence: 99%

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The Natural history of Epicardial Adipose Tissue Volume and Attenuation: A long-term prospective cohort follow-up study

Nerlekar

Thakur

Lin

et al. 2020

Sci Rep

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epicardial adipose tissue (eAt) is associated with cardiovascular risk. the longitudinal change in eAt volume (eAtv) and density (eAtd), and potential modulators of these parameters, has not been described. We prospectively recruited 90 patients with non-obstructive coronary atherosclerosis on baseline computed tomography coronary angiography (ctcA) performed for suspected coronary artery disease to undergo a repeat research CTCA. EATv in millilitres (mL) and EATd in Hounsfield units (HU) were analysed and multivariable regression analysis controlling for traditional cardiovascular risk factors (cVRf) performed to assess for any predictors of change. Secondary analysis was performed based on statin therapy. The median duration between CTCA was 4.3years. Mean EATv increased at follow-up (72 ± 33 mL to 89 ± 43 mL, p < 0.001) and mean EATd decreased (baseline −76 ± 6 HU vs. −86 ± 5 HU, p < 0.001). There were no associations between baseline variables of body mass index, age, sex, hypertension, hyperlipidaemia, diabetes or smoking on change in EATv or EATd. No difference in baseline, follow-up or delta EATv or EATd was seen in patients with (60%) or without baseline statin therapy. in this select group of patients, eAtv consistently increased and eAtd consistently decreased at long-term follow-up and these changes were independent of cVRf, age and statin use. together with the knowledge of strong associations between EAT and cardiac disease, these findings may suggest that eAt is an independent parameter rather than a surrogate for cardiovascular risk. open Scientific RepoRtS | (2020) 10:7109 | https://doi.org/10.1038/s41598-020-63135-z www.nature.com/scientificreports www.nature.com/scientificreports/ Scientific RepoRtS | (2020) 10:7109 | https://doi.org/10.1038/s41598-020-63135-zwww.nature.com/scientificreports www.nature.com/scientificreports/ however, this is reflective of the current literature in examining relevant associations of EAT. Finally, there is potential for error in using delta EAT values with potential overlap from test-retest variability. Our previous work has demonstrated limits of agreement up to 10 mL higher or lower between observers with a mean bias however of only 1 mL, however our inter-observer correlation was excellent at 0.98 with assessors blinded to scan timing and patient details. conclusion Epicardial adipose tissue volume and density demonstrate significant longitudinal changes in patients with non-obstructive coronary artery disease with a consistent increase in EAT volume and consistent decrease in EAT density. There are no clinical risk factors that appear to associate with the change in EAT parameters and this effect is also independent of statin therapy. This finding may suggest that EAT is an independent marker, rather than surrogate of cardiovascular risk.

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Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

The Natural history of Epicardial Adipose Tissue Volume and Attenuation: A long-term prospective cohort follow-up study

Nerlekar

Thakur

Lin

et al. 2020

Sci Rep

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“…Это можно сделать вручную, с помощью полуавтоматического процесса, или полностью автоматически. В исследовании I. Miyazawa et al, проводившемся на японской популяции, была выявлена взаимосвязь объема висцерального жира сердца с факторами риска развития атеросклероза [31]. В исследовании приняли участие 623 пациента без ССЗ в анамнезе.…”

Section: компьютерная томографияunclassified

The Role of Quantitative Assessment of Visceral Adipose Tissue of the Heart as a Predictor for Cardiovascular Events

Chernina¹,

Морозов²,

Низовцова³

et al. 2020

Vestn. rentgenol. radiol.

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Objective of this article – to evaluate possibilities to visualize cardiac visceral adipose tissue by echocardiography, computed tomography (CT), and magnetic resonanse imaging (MRI) and to systematize data on its physiological and pathological roles. To achieve this goal, the authors analyzed relevant Russian and foreign sources of literature in the scientific libraries eLIBRARY and PubMed, by using the keywords: “pericardial fat”, “epicardial fat”, “visceral fat of the heart”, “epicardial adipose tissue”, “pericardial adipose tissue”, and “adipocytokine”. Actual data as of November 2018 were collected. The review presents up-to-date data on the physiological and pathophysiological roles of cytokines secreted by pericardial adipose tissue, as well as on correlations and possible theories of the relationship between the volumes of pericardial adipose tissue and the development of coronary heart disease, atrial fibrillation, and metabolic syndrome. According to echocardiography, epicardial adipose tissue thickness is a reliable predictor for the presence of high-risk atherosclerotic plaques in the coronary arteries. Adipose tissue volume can be measured with high accuracy using CT (manual, semi-automatic, and automatic methods).A number of studies prove that MRI can be used for assigned tasks. The current notion of the role of these adipose depots can potentially be used in assessing the risk of cardiovascular diseases. The literature review presented confirms that visceral adipose tissue of the heart has a direct effect on the myocardium and coronary arteries and can be quantified using echocardiography, CT and MRI.

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“…Metodické nejasnosti se snaží napravit v recentním editorialu Hirata et al, kde definují epikardiální tuk jako tkáň, která adheruje k myokardu a pohybuje se současně s pohyby srdce a perikardiální tuk jako tuk adherující k perikardu a tvořící perikardiální vak (10). Editorial je komentářem k článku Miyazawy et al, který při CT vyšetření perikardiálního tuku definují tuto jednotku dokonce jako tukovou tkáň uvnitř a vně perikardiálního vaku (11).…”

Section: Epikardiální Tuk -Charakteristikaunclassified

“…Množství ET závisí na věku -s věkem přibývá (5), pohlaví -vyšší je u mužů ( 14), dále na hmotnosti -vyšší je u osob s BMI nad 27 (15) a etnické příslušnosti -vyšší u bělochů (16). Množství ET může narůstat během let, jak prokázali autoři recentní studie z Japonska (11).…”

Section: Epikardiální Tuk -Fyziologické a Patofyziologické Souvislostiunclassified

Clinical aspects of epicardial fat deposition

Sovová¹

2020

Vnitr Lek

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Klinika tělovýchovného lékařství a kardiovaskulární rehabilitace LF UP a FN Olomouc Obezita je chronické metabolické onemocnění charakterizované zvýšením zásob tělesného tuku. Zvyšuje kardiovaskulární morbiditu a mortalitu, rapidně zatěžuje společnost nejenom socioekonomicky, ale především ze zdravotního hlediska. Důležitou roli ve vzniku kardiovaskulárních onemocnění hraje především typ tzv. "centrální-androidní-abdominální-viscerální" obezity. Tuk, nyní již chápaný jako hormonálně aktivní tkáň, se zapojuje do celé řady metabolických pochodů, řízení příjmu potravy, ovlivnění lipového metabolismu, průběhu zánětlivých procesů, produkuje řadu cytokinů, účastní se kontroly tělesné teploty atd. V poslední době je věnována velká pozornost ektopicky uloženému tuku, kam patří také epikardiální tuk (ET). Je to komplexní orgán, který je tvořen adipocyty, stromálními buňkami, mikrofágy, sítí nervových vláken a kapilár. Práce shrnuje aktuální poznatky o fyziologickém a patofyziologickém působení ET, měření ET, dále se věnuje významu ET ve spojení s častými onemocněními, jako je ischemická choroba srdeční, srdeční arytmie, diabetes mellitus, chronická obstrukční plicní nemoc a onemocnění štítné žlázy.Klíčová slova: arytmie, diabetes mellitus, epikardiální tuk, chronická obstrukční plicní nemoc, ischemická choroba srdeční, metabolický syndrom, obezita. Clinical aspects of epicardial fat depositionObesity is a chronic metabolic disease which is characterized by an increased body fat. Obesity increases cardiovascular morbidity and mortality and presents an important socioeconomic burden for the health system. So-called "central-android-abdominal-visceral" obesity plays an important role in the development of cardiovascular diseases. Adipose tissue is nowadays considered to be metabolically active tissue which is involved in many metabolic processes, managing food intake, lipid metabolism regulation, and also inflammatory diseases. Many cytokines, such as those regulating body temperature, are produced by the adipose tissue. In the last few years, many studies of ectopic adipose tissue including epicardial fat were published. This is a complex organ which consists of adipocytes, stromal cells, macrophages, and network of neural cells and blood capillaries. This thesis summarizes updated information regarding physiological and pathophysiological role of epicardial fat, epicardial fat measurement and a possible connection with common diseases, such as ischemic heart disease, cardiac arrhythmias, diabetes mellitus, chronic obstructive pulmonary disease and disease of thyroid gland.

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Change in Pericardial Fat Volume and Cardiovascular Risk Factors in a General Population of Japanese Men

Cited by 12 publications

References 44 publications

The Natural history of Epicardial Adipose Tissue Volume and Attenuation: A long-term prospective cohort follow-up study

The Natural history of Epicardial Adipose Tissue Volume and Attenuation: A long-term prospective cohort follow-up study

The Role of Quantitative Assessment of Visceral Adipose Tissue of the Heart as a Predictor for Cardiovascular Events

Clinical aspects of epicardial fat deposition

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