Change in Pattern of Secondary Cancers After Kaposi Sarcoma in the Era of Antiretroviral Therapy

Mukhtar, Fahad; Ilozumba, Mmadili N.; Utuama, Ovie; Cimenler, Oguz

doi:10.1001/jamaoncol.2017.2395

Cited by 17 publications

(16 citation statements)

References 33 publications

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“…The primary outcomes were overall survival and development of SPCs in patients with metastatic melanoma. Patients with metastatic melanoma were followed up to the date they developed SPCs, 10 and by dividing the observed number of cases of second primary cancer by the expected number of cases in the general population after matching by sex, age group, and calendar year. 10 We used SIR to estimate the risk that survivors of metastatic melanoma will develop a second primary malignancy relative to the incidence of cancer among the general population.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Trends in Second Primary Cancers in Patients With Metastatic Melanoma From 2005 to 2016

Deng

Wang

Liu³

et al. 2020

JAMA Netw Open

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Key Points Question When compared with prior therapies, are immune checkpoint inhibitors for metastatic melanoma associated with development of second primary cancers? Findings In this cohort study of 5016 patients with metastatic melanoma between 2005 and 2016, the overall risk of second primary cancers increased after the introduction of immune checkpoint inhibitors. Risks for cancer of the small intestine and myeloma were higher than before the era of immune checkpoint inhibitors. Meaning In this study, a change in the incidence of second primary cancers was found; screening for these cancers may be warranted in patients treated with immune checkpoint inhibitors for metastatic melanoma.

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Section: Discussionmentioning

confidence: 99%

Assessment of Trends in Second Primary Cancers in Patients With Metastatic Melanoma From 2005 to 2016

Deng

Wang

Liu³

et al. 2020

JAMA Netw Open

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“…Consequently, gastric SPM was incidentally detected. For patients with KS, SPMs as well as multicentric KS in other sites are reportedly serious complications [10,28]. Based on our literature review, the first case of SPM (lymphatic leukemia) in a patient with KS was reported in 1920 [32].…”

Section: Discussionmentioning

confidence: 94%

“…Non-English studies and English conference proceedings were excluded. A total of 280 cases of patients with KS with multiple tumors including head and neck, esophagus, stomach, duodenum, or colorectal (including anal) malignancies were identified [7,[10][11][12][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] (Table 1). Of the identified cases, 7, 20, 1, and 159 had KS with esophagus, stomach, duodenum, and colorectal (including anal) malignancy, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…However, no previous cases were similar to the current combination of tumors. We then attempted to investigate how these tumors were detected (by clinical symptoms, radiological methods, or EGD/CS) in the literature presented in Table 1; however, detection methods could not be found because most of the identified studies were based on cancer registries that did not describe the detailed case information [10,11,17,28]. Biopsy of the mass histologically revealed a high-grade (group 4) gastric adenoma, which was also suspected as gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…For patients with KS, second primary malignancies (SPMs) are a serious problem [9,10]. SPMs in patients with KS can occur > 15 years after the CKS diagnosis [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Quadruple Multiple Primary Malignancies: Early Detection of Second Primary Malignancy by Esophagogastroduodenoscopy/Colonoscopy Is Crucial for Patients with Classic Kaposi’s Sarcoma

et al. 2020

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Currently, Kaposi’s sarcoma (KS) is treated following the recommendations of international guidelines. These guidelines recommend esophagogastroduodenoscopy/colonoscopy for detecting multicentric KS of visceral lesions. Second primary malignancies (SPMs) are also a common KS complication; however, information on their detection and treatment is unfortunately not yet indicated in these guidelines. This paper reports on an 86-year-old man who suffered from quadruple primary malignancies: skin classic KS with colon adenocarcinoma, oral squamous cell carcinoma (maxilla), and well-differentiated stomach adenocarcinoma. Gastric cancer was incidentally detected during esophagogastroduodenoscopy, which was performed to detect visceral KS. We suggest that esophagogastroduodenoscopy/colonoscopy be routinely performed during the follow-up of patients with KS. As SPMs are crucial complications in patients with KS, these malignancies should be detected as early as possible.

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Association of First Primary Cancer With Risk of Subsequent Primary Cancer Among Survivors of Adult-Onset Cancers in the United States

Sung

Hyun

Leach

et al. 2020

JAMA

123

143

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The number of cancer survivors who develop new cancers is projected to increase, but comprehensive data on the risk of subsequent primary cancers (SPCs) among survivors of adult-onset cancers are limited.OBJECTIVE To quantify the overall and cancer type-specific risks of SPCs among adult-onset cancer survivors by first primary cancer (FPC) types and sex. DESIGN, SETTING, AND PARTICIPANTSA retrospective cohort study from 12 Surveillance, Epidemiology, and End Results registries in the United States, that included 1 537 101 persons aged 20 to 84 years diagnosed with FPCs from 1992-2011 (followed up until December 31, 2017) and who survived at least 5 years.EXPOSURES First primary cancer. MAIN OUTCOMES AND MEASURESIncidence and mortality of SPCs per 10 000 person-years; standardized incidence ratio (SIR) and standardized mortality ratio (SMR) compared with those expected in the general population.RESULTS Among 1 537 101 survivors (mean age, 60.4 years; 48.8% women), 156 442 SPC cases and 88 818 SPC deaths occurred during 11 197 890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general population. Among women, the overall risk of developing any SPCs was statistically significantly higher for 21 of the 31 FPC types, and risk of dying from any SPCs was statistically significantly higher for 28 of 31 FPC types as compared with risks in the general population. The highest overall SIR and SMR were estimated among survivors of laryngeal cancer (SIR, 1.75 [95% CI, 1.68-1.83]; incidence, 373 per 10 000 person-years) and gallbladder cancer (SMR, 3.82 [95% CI,; mortality, 341 per 10 000 person-years) among men, and among survivors of laryngeal cancer (SIR, 2.48 [95% CI, 2.27-2.72]; incidence, 336 per 10 000 person-years; SMR, 4.56 [95% CI,; mortality, 268 per 10 000 person-years) among women. Substantial variation existed in the associations of specific types of FPCs with specific types of SPC risk; however, only a few smoking-or obesity-associated SPCs, such as lung, urinary bladder, oral cavity/pharynx, colorectal, pancreatic, uterine corpus, and liver cancers constituted considerable proportions of the total incidence and mortality, with lung cancer alone accounting for 31% to 33% of mortality from all SPCs.CONCLUSIONS AND RELEVANCE Among survivors of adult-onset cancers in the United States, several types of primary cancer were significantly associated with greater risk of developing and dying from an SPC, compared with the general population. Cancers associated with smoking or obesity comprised substantial proportions of overall SPC incidence and mortality among all survivors and highlight the importance of ongoing surveillance and efforts to prevent new cancers among survivors.

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Change in Pattern of Secondary Cancers After Kaposi Sarcoma in the Era of Antiretroviral Therapy

Cited by 17 publications

References 33 publications

Assessment of Trends in Second Primary Cancers in Patients With Metastatic Melanoma From 2005 to 2016

Assessment of Trends in Second Primary Cancers in Patients With Metastatic Melanoma From 2005 to 2016

Quadruple Multiple Primary Malignancies: Early Detection of Second Primary Malignancy by Esophagogastroduodenoscopy/Colonoscopy Is Crucial for Patients with Classic Kaposi’s Sarcoma

Association of First Primary Cancer With Risk of Subsequent Primary Cancer Among Survivors of Adult-Onset Cancers in the United States

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