Change in PASAT performance correlates with change in P3 ERP amplitude over a 12-month period in multiple sclerosis patients

Kiiski, Hanni; Reilly, Richard B.; Lonergan, Roisin; Kelly, Siobhán; O’Brien, Marie; Kinsella, Katie; Bramham, Jessica; Burke, Teresa; O'Donnchadha, S.; Nolan, Hugh; Hutchinson, Michael; Tubridy, Niall; Whelan, Robert

doi:10.1016/j.jns.2011.03.018

Cited by 15 publications

(16 citation statements)

References 43 publications

(78 reference statements)

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“…These differences were expected to be more prominent in the IC clusters located in the parietal brain areas which were associated with P3b activities in prior IC clustering studies [37], [42], [44], [45], and in visual modality based on the previous studies of our research group [22], [26].…”

Section: Methodsmentioning

confidence: 83%

“…In our previous scalp-based high-density EEG study [22], with a relatively large number of subjects (N = 54), we showed that MS patients had reduced P3b amplitudes over frontal and centro-parietal scalp areas in the visual task, but there were no statistically significant differences in auditory modality. Furthermore, in a subsequent longitudinal high-density EEG analysis [26] we demonstrated visual modality to be more sensitive in detecting a greater reduction of P3b amplitudes over the centro-parietal scalp region in MS patients relative to controls over 12-month period. Moreover, both visual and auditory P3b amplitudes had decreased over the centro-parietal scalp area in MS patients after 12 Months.…”

Section: Introductionmentioning

confidence: 74%

“…Previous EEG studies of cognitive functioning in MS have only examined the differences between the mean ERPs of MS patients and controls [12], [13], [14], [15], [16], [17], [18], [19], [22], [26], [32]. The informativeness of ERPs is restricted due to the fact that they are generated by multiple, functionally distinct neural sources, which cause EEG potentials recorded on the scalp to overlap both temporally and spatially [33], [34].…”

Section: Introductionmentioning

confidence: 99%

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Only Low Frequency Event-Related EEG Activity Is Compromised in Multiple Sclerosis: Insights from an Independent Component Clustering Analysis

et al. 2012

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Cognitive impairment (CI), often examined with neuropsychological tests such as the Paced Auditory Serial Addition Test (PASAT), affects approximately 65% of multiple sclerosis (MS) patients. The P3b event-related potential (ERP), evoked when an infrequent target stimulus is presented, indexes cognitive function and is typically compared across subjects' scalp electroencephalography (EEG) data. However, the clustering of independent components (ICs) is superior to scalp-based EEG methods because it can accommodate the spatiotemporal overlap inherent in scalp EEG data. Event-related spectral perturbations (ERSPs; event-related mean power spectral changes) and inter-trial coherence (ITCs; event-related consistency of spectral phase) reveal a more comprehensive overview of EEG activity. Ninety-five subjects (56 MS patients, 39 controls) completed visual and auditory two-stimulus P3b event-related potential tasks and the PASAT. MS patients were also divided into CI and non-CI groups (n = 18 in each) based on PASAT scores. Data were recorded from 128-scalp EEG channels and 4 IC clusters in the visual, and 5 IC clusters in the auditory, modality were identified. In general, MS patients had significantly reduced ERSP theta power versus controls, and a similar pattern was observed for CI vs. non-CI MS patients. The ITC measures were also significantly different in the theta band for some clusters. The finding that MS patients had reduced P3b task-related theta power in both modalities is a reflection of compromised connectivity, likely due to demyelination, that may have disrupted early processes essential to P3b generation, such as orientating and signal detection. However, for posterior sources, MS patients had a greater decrease in alpha power, normally associated with enhanced cognitive function, which may reflect a compensatory mechanism in response to the compromised early cognitive processing.

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Section: Methodsmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Only Low Frequency Event-Related EEG Activity Is Compromised in Multiple Sclerosis: Insights from an Independent Component Clustering Analysis

et al. 2012

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“…Moreover, a delay in the latency for early ERP components (P1 and N1) triggered by the target stimuli and a decrement for the amplitude in the P3 component related to impairment in more central cognitive processes are also expected. Finally, neuropsychological scores will probably show some degree of correlation with psychophysiological measures we have used (behavioral or ERP parameters), as described elsewhere [27], [28].…”

Section: Introductionmentioning

confidence: 99%

Neural Correlates of Alerting and Orienting Impairment in Multiple Sclerosis Patients

et al. 2014

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BackgroundA considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied. Previous behavioural studies using this test have shown that the alerting network is impaired in multiple sclerosis. The aim of this study was to identify neurophysiological indexes of the attention impairment in relapsing-remitting multiple sclerosis patients using this test.ResultsAfter general slowing had been removed in patients group to isolate the effects of each condition, some behavioral differences between them were obtained. About Contingent Negative Variation, a statistically significant decrement were found in the amplitude for Central and Spatial Cue Conditions for patient group (p<0.05). ANOVAs showed for the patient group a significant latency delay for P1 and N1 components (p<0.05) and a decrease of P3 amplitude for congruent and incongruent stimuli (p<0.01). With regard to correlation analysis, PASAT-3s and SDMT showed significant correlations with behavioral measures of the Attention Network Test (p<0.01) and an ERP parameter (CNV amplitude).ConclusionsBehavioral data are highly correlated with the neuropsychological scores and show that the alerting and orienting mechanisms in the patient group were impaired. Reduced amplitude for the Contingent Negative Variation in the patient group suggests that this component could be a physiological marker related to the alerting and orienting impairment in relapsing-remitting multiple sclerosis. P1 and N1 delayed latencies are evidence of the demyelination process that causes impairment in the first steps of the visual sensory processing. Lastly, P3 amplitude shows a general decrease for the pathological group probably indexing a more central impairment. These results suggest that the Attention Network Test give evidence of multiple levels of attention impairment, which could help in the assessment and treatment of relapsing-remitting multiple sclerosis patients.

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“…It has become a common outcome measure in clinical trials and, in particular, has become a useful tool to monitor cognitive change over time. Longitudinal change in PASAT scores do not correlate with change in EDSS scores, [17] but PASAT performance does correlate with imaging parameters such as DTI measures, [18] MTR in normal appearing white matter, [19,20] brain activation using fMRI, [21,22] atrophy, [23] and gadolinium enhancement (a marker of active inflammatory activity), [24] as well as electrophysiological measures such as P3 ERP [25]. Thus, this measure is an easily administered clinical tool that can be a marker for underlying disease progression.…”

Section: Introductionmentioning

confidence: 97%

Longitudinal change in Paced Auditory Serial Addition Test (PASAT) performance following immunoablative therapy and haematopoietic stem cell transplant in multiple sclerosis

Walker

Berard

Bowman

et al. 2016

Mult Scler Demyelinating Disord

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Background: Immediately following immunoablation and hematopoietic stem cell transplantation (IA-HSCT) for MS a median decrease in brain volume of 3.2 % over 2.4 months occurs. After 2 years, rates of atrophy are comparable to normal volunteers. Potential impact of atrophy on cognition was evaluated by examining performance on the Paced Auditory Serial Addition Test (PASAT) pre-and post-IA-HSCT. Methods: Twenty-three individuals with rapidly progressing/poor prognosis MS underwent high dose IA-HSCT. Individuals completed the 3" PASAT at baseline and 6/12/18/24/30/36 months post-procedure. Results: Mean decline in performance between baseline and 6-months occurred, though it was not statistically significant. Minor declines were offset by an overall trend for improvement over time. The largest (non-significant) cognitive gains were between months 30 and 36. Neither level of impairment at baseline, nor demographic variables, influenced likelihood of improvement. No relationship between changes in cognition and changes in volumes was detected, likely secondary to small sample size. Conclusions: While an initial decline in cognition was noted 6 months post-IA-HSCT, there were no lasting negative effects of treatment given the overall trend for improvement. Initial cognitive decline and marked volume loss are likely secondary to acute toxic effects of chemotherapy. Gains in cognition noted over 36 months suggest long-term follow-up is essential.

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Change in PASAT performance correlates with change in P3 ERP amplitude over a 12-month period in multiple sclerosis patients

Cited by 15 publications

References 43 publications

Only Low Frequency Event-Related EEG Activity Is Compromised in Multiple Sclerosis: Insights from an Independent Component Clustering Analysis

Only Low Frequency Event-Related EEG Activity Is Compromised in Multiple Sclerosis: Insights from an Independent Component Clustering Analysis

Neural Correlates of Alerting and Orienting Impairment in Multiple Sclerosis Patients

Longitudinal change in Paced Auditory Serial Addition Test (PASAT) performance following immunoablative therapy and haematopoietic stem cell transplant in multiple sclerosis

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