Change in Oxygen Saturation Does Not Predict Acute Mountain Sickness on Jade Mountain

Chen, Hang Cheng; Lin, Wen Ling; Wu, Jiunn Yih; Wang, Shih Hao; Chiu, Te Fa; Weng, Yi Ming; Hsu, Tai Yi; Wu, Meng

doi:10.1016/j.wem.2012.03.014

Cited by 41 publications

(32 citation statements)

References 10 publications

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“…Overall, SO 2 values did not differ between groups with or without AMS. This is in agreement with some (Chen et al, 2012;Wagner et al, 2012), but not all studies (Karinen et al, 2010(Karinen et al, , 2012. Moreover, oxygen saturation may be difficult to measure in a standardized way depending on the conditions in the field.…”

Section: Acute Mountain Sickness In Childrensupporting

confidence: 90%

“…The existence of cerebral dysfunction possibly due to mild cerebral oedema as a consequence of inadequate acclimatisation to hypobaric hypoxia is the dominant hypothesis (Hackett and Roach, 2001;Imray et al, 2010). Yet, oxygen saturation (SO 2 ) has been shown to be (Roach et al, 1998;Karinen et al, 2010) or not to be (Chen et al, 2012;Wagner et al, 2012) related to AMS. Furthermore, the individual's sensitivity to pain might play a role in determining the severity and prevalence of AMS symptoms (by sympathetic activation) as hypoxia is known to reduce the pain, taste, or tactile threshold to sensory stimuli as shown in nonacclimatized lowlanders upon acute exposure to HA (Noel-Jorand et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Acute Mountain Sickness at 3500 m Within and Between Families: A Prospective Cohort Study

Kriemler

Bürgi

Wick

et al. 2014

High Altitude Medicine & Biology

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AIM: To investigate symptoms, prevalence and associated factors of acute mountain sickness (AMS) in families upon a fast ascent to 3450 m. Methods: 87 children, 70 adolescents, and 155 parents (n=312) were assessed for AMS 8-10 and 20-24 hours after fast passive ascent by the Lake Louise Score (LLS). Pain sensitivity and oxygen saturation (SO2) were measured and familial clustering was assessed. RESULTS: AMS prevalence was significantly lower in children (21%) compared to adolescents (34%) and adults (39%) on day 1 (p<0.05), but not on day 2 (18% vs. 19% and 25%). Cumulative prevalence of AMS was 30, 37, and 45% in children, adolescents, and adults, respectively (p<0.001). Familial clustering of AMS was consistent and explained 25%-50% of variability in AMS. Pain sensitivity significantly increased from low to high altitude and was higher at low altitude in those with compared to those without AMS. SO2 at high altitude was not related to the presence of AMS. CONCLUSIONS: After fast ascent to 3500 m, AMS prevalence was lower in children than in adolescents and adults on day 1, but not on day 2. Thus, children may travel at least as safely to an altitude of 3500 m as adolescents and adults, even if risk factors (pain sensitivity and heredity) are present. Methods: 87 children, 70 adolescents, and 155 parents (n = 312) were assessed for AMS 8-10 and 20-24 hours after fast passive ascent by the Lake Louise Score (LLS). Pain sensitivity and oxygen saturation (SO 2 ) were measured and familial clustering was assessed.Results: AMS prevalence was significantly lower in children (21%) compared to adolescents (34%) and adults (39%) on day 1 ( p < 0.05), but not on day 2 (18% vs. 19% and 25%). Cumulative prevalence of AMS was 30, 37, and 45% in children, adolescents, and adults, respectively ( p < 0.001). Familial clustering of AMS was consistent and explained 25%-50% of variability in AMS. Pain sensitivity significantly increased from low to high altitude and was higher at low altitude in those with compared to those without AMS. SO 2 at high altitude was not related to the presence of AMS. Conclusions: After fast ascent to 3500 m, AMS prevalence was lower in children than in adolescents and adults on day 1, but not on day 2. Thus, children may travel at least as safely to an altitude of 3500 m as adolescents and adults, even if risk factors (pain sensitivity and heredity) are present.

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Section: Acute Mountain Sickness In Childrensupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Prevalence of Acute Mountain Sickness at 3500 m Within and Between Families: A Prospective Cohort Study

Kriemler

Bürgi

Wick

et al. 2014

High Altitude Medicine & Biology

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show abstract

“…If the detection of S O 2 predicts AMS effectively, both the syndrome and its deadly complications HAPE and HACE can be avoided through prevention. Certain studies have shown that arterial oxygen saturation (S O 2 ) is associated with susceptibility of AMS, while others studies found no association [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

“…If the detection of S O 2 can predict the occurrence of AMS effectively, AMS can likely be avoided prior to the occurrence of the deadly complications high altitude pulmonary edema (HAPE) or high altitude cerebral edema (HACE). Some studies have shown that there is a significant association between Sa O 2 and the susceptibility of AMS [19][20][21][22][23][24][25][26][27], while others suggest that there is no correlation [28][29][30][31][32]. To provide a more reliable conclusion, we performed a meta-analysis of the published studies to evaluate the association of Sa O 2 with AMS.…”

Section: Introductionmentioning

confidence: 99%

Association of Arterial Oxygen Saturation and Acute Mountain Sickness Susceptibility: A Meta-analysis

Guo

Zhu

Sun

et al. 2014

Cell Biochem Biophys

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Acute mountain sickness (AMS) is the most common high altitude illnesses experienced during rapid ascent to a higher altitude without prior acclimation. It is mainly characterized by a headache which may be accompanied with nausea, vomiting, anorexia, dizziness, lethargy, fatigue, and sleep disturbance. If not diagnosed and treated in a timely manner, AMS can develop into deadly high altitude pulmonary edema or high altitude cerebral edema. In the previous studies of individual variation in susceptibility to AMS, arterial oxygen saturation (SO2) was identified as being associated with AMS. However, other studies have reported no association between AMS and arterial oxygen saturation. In this study, the association between SO2 and AMS was assessed through a meta-analysis of published data. The literature databases PubMed, Web of Science, LWW, Science Direct, and Embase were queried for papers published before 15 April 2014. A fixed-effects model and a random-effects model were applied (Revman 5.0) on the basis of heterogeneity, and the study quality was assessed in duplicate. Twelve studies with 614 AMS patients and 1,025 control subjects were analyzed. There was a significant association with differences in SO2 and the risk of developing AMS. SO2 values are associated with AMS incidence.

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“…Many investigators related the history or the occurrence of acute high altitude illnesses with the hypoxic ventilatory response (HVR) Hohenhaus et al, 1995;Milledge et al, 1988;Moore et al, 1986;Richalet et al, 1989;Richalet et al, 2012) or the arterial oxygen saturation (SaO 2 ) measured after a brief hypoxic exposure at low or moderate altitude at rest (Burtscher et al, 2004;Chen et al, 2012;Richalet et al, 1989;Richalet et al, 2012). Most studies involved few subjects and therefore did not find significant differences of HVR or SaO 2 between those who had or were going to develop AMS vs. controls because of the wide inter-individual variability of the hypoxic responses.…”

mentioning

confidence: 99%

Con: Hypoxic Cardiopulmonary Exercise Testing Identifies Subjects at Risk for Severe High Altitude Illnesses

BärtschPeter

2014

High Altitude Medicine & Biology

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Change in Oxygen Saturation Does Not Predict Acute Mountain Sickness on Jade Mountain

Abstract: Subjects with AMS had a lower Spo(2) than those without AMS; however, the differences between the 2 groups were not clinically significant. The results of this study do not support the use of pulse oximetry in predicting AMS on Jade Mountain.

Cited by 41 publications

References 10 publications

Prevalence of Acute Mountain Sickness at 3500 m Within and Between Families: A Prospective Cohort Study

Prevalence of Acute Mountain Sickness at 3500 m Within and Between Families: A Prospective Cohort Study

Association of Arterial Oxygen Saturation and Acute Mountain Sickness Susceptibility: A Meta-analysis

Con: Hypoxic Cardiopulmonary Exercise Testing Identifies Subjects at Risk for Severe High Altitude Illnesses

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