Change in lung function of patients with cystic fibrosis underwent lung transplantation

Abstract

The aim of this study was to evaluate changes in lung ventilation and lung diffusing capacity (DLCO) of cystic fibrosis (CF) patients during 1 year after lung transplantation. Methods. Complex lung function was monitored in CF patients underwent bilateral lung transplantation in 2012 – 2016. Results. CF patients (n = 12; mean age, 26.4 ± 4.4 years) were included in the study. Median follow-up after the lung transplantation was 19 (12–57) months. Consistent improvement in lung function parameters and DLCO was observed in 3 months after lung transplantation and maintained during 1 year. The ratio of forced expiratory volume in 1 sec to forced vital capacity was higher the normal level and the bronchial resistance was lower the cut-off values, i.e. the patients did not have bronchial obstruction. The total lung capacity (TLC) decreased to normal according to the anthropometric characteristics of the recipient. Meanwhile, change in the TLC structure, such as non-significant reduction in the vital capacity (VC) together with increase in the functional residual capacity (FRC), residual volume (RV) and RV/TLC ratio, have been developed. Consistent increase in FRC and RV could be explained by changes in the shape and the elasticity of the chest wall after the surgery. DLCO also improved, but was still slightly decreased. Conclusion. The lung function and DLCO improved in a year after bilateral lung transplantation in CF patients. Effects of different factors on postoperative lung function parameters need to be further investigated.

The dynamics of some health indicators in adult patients with cystic fibrosis, observed in the research institute of pulmonology in 2003-2018

“…На настоящий момент этот список можно дополнить реализацией программы трансплантации легких (с 2012 г. эта операция проведена 36 пациентам с МВ), внедрением в рутинную практику гастростомии и началом патогенети-ческого лечения. Необходимо отметить, что перечисленные выше современные методы были инициированы и внедрены под началом и при непосредственном участии сотрудников лаборатории муковисцидоза НИИ пульмонологии [5][6][7]. Но если такое многообещающее лечение, как патогенетическое, на конец 2018 года проведено всего лишь нескольким пациентам в России и никак существенно не повлияло на показатели статистики, то трансплантация легких и тесно связанная с ней ночная гипералиментация через гастростому уже сыграли свою роль в сохранении жизни нескольких десятков пациентов.…”