Change in inflammatory cytokine profiles after transarterial chemotherapy in patients with hepatocellular carcinoma

Kim, Min Ju; Jang, Jeong Won; Oh, Byong Sun; Kwon, Jung Hyun; Chung, Kyu Won; Jung, Hyun Suk; Jekarl, Dong Wook; Lee, Seungok

doi:10.1016/j.cyto.2013.07.021

Cited by 72 publications

(63 citation statements)

References 22 publications

(33 reference statements)

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“…IL-22 is involved in multiple inflammatory processes and has also been shown to enhance progression of gastric, hepatocellular, and skin carcinoma (29)(30)(31)(32)(33)(34). It mediates its effects via a heterodimeric receptor that is highly expressed in epithelial cells of the skin and other organs.…”

Section: Discussionmentioning

confidence: 99%

Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22

Abikhair¹,

Mitsui²,

Yanofsky³

et al. 2016

JCI Insight

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Section: Discussionmentioning

confidence: 99%

Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22

Abikhair¹,

Mitsui²,

Yanofsky³

et al. 2016

JCI Insight

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“…A useful alternative to this would be the use of syngeneic tumor models or other transgenic models of spontaneous cancers. Furthermore, as certain therapeutic compounds may have immunomodulatory properties [190][191][192][193][194][195], the use of an immune-intact system could help elucidate whether such secondary effects would enhance or diminish treatment efficacy through stimulating or further suppressing the anti-cancer immune response.…”

Section: Immune Cell Subtypes Summary Of Functions Referencesmentioning

confidence: 99%

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

Choi¹,

Lin²,

Gout³

et al. 2014

Advanced Drug Delivery Reviews

157

134

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The development of novel cancer therapeutics is often plagued by discrepancies between drug efficacies obtained in preclinical studies and outcomes of clinical trials. The inconsistencies can be attributed to a lack of clinical relevance of the cancer models used for drug testing. While commonly used in vitro culture systems are advantageous for addressing specific experimental questions, they are often gross, fidelity-lacking simplifications that largely ignore the heterogeneity of cancers as well as the complexity of the tumor microenvironment. Factors such as tumor architecture, interactions among cancer cells and between cancer and stromal cells, and an acidic tumor microenvironment are critical characteristics observed in patient-derived cancer xenograft models and in the clinic. By mimicking these crucial in vivo characteristics through use of 3D cultures, co-culture systems and acidic culture conditions, an in vitro cancer model/microenvironment that is more physiologically relevant may be engineered to produce results more readily applicable to the clinic.

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“…PCT was measured by sandwich immunoassay using a VIDAS BRAHMS PCT kit (bioMerieux, Marcy L'Etoile, France) with a functional assay sensitivity of 0.05 ng/mL. Cytokines were measured simultaneously as previously reported [15]. In brief, IL1β, IL2, IL4, IL5, IL6, IL9, IL10, IL12p70, IL13, IL17, IL22, TNFα, and IFNγ were measured via a multiplex fluorescent bead assay using FlowCytomix (eBioscience, San Diego, CA, USA) and a BD Facs Canto II (BD Bioscience, Sparks, MD, USA).…”

Section: Laboratory Examinationmentioning

confidence: 99%

Diagnosis and evaluation of severity of sepsis via the use of biomarkers and profiles of 13 cytokines: a multiplex analysis

Jekarl¹,

Kim²,

Lee³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Change in inflammatory cytokine profiles after transarterial chemotherapy in patients with hepatocellular carcinoma

Cited by 72 publications

References 22 publications

Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22

Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

Diagnosis and evaluation of severity of sepsis via the use of biomarkers and profiles of 13 cytokines: a multiplex analysis

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