Change in gene expression levels of GABA, glutamate and neurosteroid pathways due to acoustic trauma in the cochlea

Gunes, Meltem Cerrah; Güneş, Murat Salih; Vural, Alperen; Aybuga, Fatma; Bayramov, Ruslan; Bayramov, Keziban Korkmaz; Şahin, Mehmet İlhan; Doğan, Muhammet Ensar; Ozdemir, Sevda Yesim; Özkul, Yusuf

doi:10.1080/01677063.2021.1904922

Cited by 4 publications

(1 citation statement)

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“…Although the mechanisms underlying neuronal gain modification are not fully understood, one possibility is a reduction in synaptic inhibition mediated by neurotransmitters such as GABA and glycine ( 191 ). Consistent with this assumption, studies in animal models of acoustic trauma indicated an imbalance between excitation and inhibition in the auditory system due to impaired GABAergic neurotransmission ( 192 – 196 ), including reduced GABA B R expression in the auditory brainstem ( 121 , 122 ). The latter showed that neurons in the molecular and fusiform layers of the DCN exhibit reduced GABA B R density in mice after acoustic trauma, presumably as a result of receptor internalization due to its phosphorylation by protein kinase C gamma ( 121 , 122 ).…”

Section: The Role Of Subcortical Gaba B Rs In Path...mentioning

confidence: 75%

The role of GABAB receptors in the subcortical pathways of the mammalian auditory system

Tureček,

Melichar,

Králíková

et al. 2023

Front. Endocrinol.

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GABAB receptors are G-protein coupled receptors for the inhibitory neurotransmitter GABA. Functional GABAB receptors are formed as heteromers of GABAB1 and GABAB2 subunits, which further associate with various regulatory and signaling proteins to provide receptor complexes with distinct pharmacological and physiological properties. GABAB receptors are widely distributed in nervous tissue, where they are involved in a number of processes and in turn are subject to a number of regulatory mechanisms. In this review, we summarize current knowledge of the cellular distribution and function of the receptors in the inner ear and auditory pathway of the mammalian brainstem and midbrain. The findings suggest that in these regions, GABAB receptors are involved in processes essential for proper auditory function, such as cochlear amplifier modulation, regulation of spontaneous activity, binaural and temporal information processing, and predictive coding. Since impaired GABAergic inhibition has been found to be associated with various forms of hearing loss, GABAB dysfunction could also play a role in some pathologies of the auditory system.

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