Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative

Hunter, David J.; Niu, Jingbo; Zhang, Yuqing; Tötterman, S.; Tamez, J.; Dabrowski, Christine; Davies, R.Y.; Graverand, Marie‐Pierre Hellio Le; Luchi, Monica; Tymofyeyev, Yevgen; Beals, Chan R.

doi:10.1136/ard.2007.082107

Cited by 108 publications

(123 citation statements)

References 26 publications

(23 reference statements)

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“…39 the denudation of cartilage (a process that exposes subchondral bone) is unlikely to be reversible and by the time radiographic oa develops, the over whelming ma jority of these patients have areas of denuded cartilage. 98 mri r e V I e W s studies provide strong evidence that ascertainment of disease on the basis of radio graphy only provides insight into late-stage disease. [99][100][101] attempts to prevent joint destruction in these indivi duals will, therefore, be focused upon preserving whatever structural integrity remains.…”

Section: Avocado-soybean Unsaponifiablesmentioning

confidence: 97%

Pharmacologic therapy for osteoarthritis—the era of disease modification

2010

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Osteoarthritis (OA) is a prevalent and disabling condition for which few safe and effective therapeutic options are available. Current approaches are largely palliative and in an effort to mitigate the rising tide of increasing OA prevalence and disease impact, modifying the structural progression of OA has become a focus of drug development. This Review describes disease modification and discusses some of the challenges involved in the discovery and development of disease-modifying OA drugs (DMOADs). A variety of targeted agents are in mature phases of development; specific agents that are beyond preclinical development in phase II and III trials and show promise as potential DMOADs are discussed. A research agenda with respect to disease modification in OA is also provided, and some of the future challenges we face in this field are discussed.

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Section: Avocado-soybean Unsaponifiablesmentioning

confidence: 97%

Pharmacologic therapy for osteoarthritis—the era of disease modification

2010

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“…Metrics of cartilage morphology (volume, thickness, and others) based on MRI have been shown to be reproducible in single (1,3) and multicenter studies (4) and hold promise for evaluating the treatment response of structure/disease-modifying drugs. Several studies have reported the rate and sensitivity to change of cartilage morphology measures in participants with OA (5)(6)(7)(8)(9)(10)(11) and healthy persons (12-15) using 1.5T (1,3,16) or 3T MRI (17)(18)(19). Some of these studies have compared measures of change based on MRI to joint-space narrowing from radiographs (7,10,11,17,20).…”

mentioning

confidence: 99%

An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee

Buck¹,

Wyman

Graverand

et al. 2010

Magn. Reson. Med.

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The relationship between three-dimensional, MRI-based morphologic measurements commonly taken of knee cartilage was examined to determine whether a subset of variables fully reflects differences observed in cartilage in cross-sectional and longitudinal studies. The benefits of a subset of measures include increased statistical power due to reduced multiple comparisons, improved understanding of relationships between the morphologic measures of articular knee cartilage, and greater efficiency in reporting results. One hundred fifty-two women (77 healthy and 75 with knee osteoarthritis) had coronal 3-T MR images of the knee acquired at baseline and at 24 months. Measures of femorotibial cartilage morphology (surface area, thickness, volume, etc.) were determined in the medial and lateral tibia and femur. Cartilage thickness (mean cartilage thickness over the total area of the [subchondral] bone), total subchondral bone area, and percentage of denuded area of the subchondral bone were found to explain over 90% of the cross-sectional and longitudinal variation observed in other measures of cartilage morphology commonly reported in knee osteoarthritis. Hence, these three measures of cartilage morphology explain nearly all variation in a larger set of common cartilage morphology measures both cross-sectionally and longitudinally, both in healthy and in osteoarthritic knees. These variables hence define an efficient subset for describing structural status and change in osteoarthritic cartilage. Magn Reson Med 63:680-690, 2010.V C 2010 Wiley-Liss, Inc.

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“…Only a small proportion of patients lose significant joint space in some studies of knee joint osteoarthritis or of treatments for knee OA [10][11][12]. The average rate of JSN is small in most studies [11,13].…”

Section: Discussionmentioning

confidence: 99%

“…The average rate of JSN is small in most studies [11,13]. It is therefore important to accurately identify all subjects with a significant change in joint space.…”

Section: Discussionmentioning

confidence: 99%

Accuracy and Reproducibility of Radiographic Knee Joint Space Narrowing Measurements Referenced to the Mid-Coronal Plane

Hipp¹,

Goel²,

Newman³

et al. 2015

TOJ

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Introduction: Knee joint space narrowing (JSN) is a primary outcome measure in the progression of knee osteoarthritis and its treatment. JSN is most frequently determined from radiographs relying on the radiographic shadow of the anterior or posterior margins of the tibial plateau. Several studies address the confounding issues related to use of the anterior and posterior margins of the tibial plateau. An alternative strategy is to identify the mid-coronal plane of the tibial plateau and use that as a reference for measuring JSN. Methods: Radiographs with precisely defined changes in joint space width (JSW) were created from CT imaging of cadaver knees. The mid-coronal plane of the knee was used to measure JSW and calculate JSN. Radiographs and data from the Osteoarthritis Initiative study were used to assess reproducibility and compare mid-coronal plane measurements of JSN to previously reported methods. Results:The average absolute error in the measured versus known medial JSN was below 0.2 mm. The reproducibility was similar to previously published methods. There was a strong correlation between the mid-coronal plane measurements of JSN and JSN calculated using previously reported methods. There were several discrepancies between the two methods, suggesting that JSN for individual cases may depend on the method used to measure JSN. Discussion: This study describes an alternative to using the margins of the tibial plateau when calculating JSN. JSN measurements based on the mid-coronal plane of the knee, where cartilage changes are more likely to occur, may have advantages.

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Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative

Cited by 108 publications

References 26 publications

Pharmacologic therapy for osteoarthritis—the era of disease modification

Pharmacologic therapy for osteoarthritis—the era of disease modification

An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee

Accuracy and Reproducibility of Radiographic Knee Joint Space Narrowing Measurements Referenced to the Mid-Coronal Plane

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