Change in body mass index from childhood onwards and risk of adult cardiovascular disease,

Bjerregaard, Lise G.; Adelborg, Kasper; Baker, Jennifer L.

doi:10.1016/j.tcm.2019.01.011

Cited by 41 publications

(37 citation statements)

References 39 publications

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“…Maternal and childhood obesity are new risk factors for later life CVD (Bjerregaard et al 2019). From 1989 to 2007, maternal BMI greater than 30 Kg/m2 (Heslehurst et al 2010) in association with childhood obesity (Heslehurst et al 2019).…”

Section: Birth Weight and Fetal Growth Retardationmentioning

confidence: 99%

The Exposome in Human Evolution: From Dust to Diesel

Trumble¹,

Finch²

2019

The Quarterly Review of Biology

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Global exposures to air pollution and cigarette smoke are novel in human evolutionary history and are associated with about 16 million premature deaths per year. We investigate the history of the human exposome for relationships between novel environmental toxins and genetic changes during human evolution in six phases. Phase I: With increased walking on savannas, early human ancestors inhaled crustal dust, fecal aerosols, and spores; carrion scavenging introduced new infectious pathogens. Phase II: Domestic fire exposed early Homo to novel toxins from smoke and cooking. Phases III and IV: Neolithic to preindustrial Homo sapiens incurred infectious pathogens from domestic animals and dense communities with limited sanitation. Phase V: Industrialization introduced novel toxins from fossil fuels, industrial chemicals, and tobacco at the same time infectious pathogens were diminishing. Thereby, pathogen-driven causes of mortality were replaced by chronic diseases driven by sterile inflammogens, exogenous and endogenous. Phase VI: Considers future health during global warming with increased air pollution and infections. We hypothesize that adaptation to some ancient toxins persists in genetic variations associated with inflammation and longevity.

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Section: Birth Weight and Fetal Growth Retardationmentioning

confidence: 99%

The Exposome in Human Evolution: From Dust to Diesel

Trumble¹,

Finch²

2019

The Quarterly Review of Biology

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“…Ohlsson et al [148] conducted a study exclusively on male subjects; overweight boys during adolescence and overweight boys during childhood and youth, which showed they had an increased risk of cardiovascular mortality compared with normal-weight subjects (hazard ratio [HR] 2.39, 95% CI 1.86-3.09; HR 1.85, 95% CI 1.28-2.67; respectively). Childhood obesity involves an increased risk of CHD, which may be mediated by cardiovascular risk factors [151]; in fact, the cumulative burden of this conventional risk factors in this setting patients may alter premature steps in atherosclerosis [152]. Moreover, the development of these risk factors begins very early and also in the initial degrees of obesity.…”

Section: Cardiovascular Riskmentioning

confidence: 99%

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Scudiero

Pero

Ranieri

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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In the last few years, a significant increase of childhood obesity incidence unequally distributed within countries and population groups has been observed, thus representing an important public health problem associated with several health and social consequences. Obese children have more than a 50% probability of becoming obese adults, and to develop pathologies typical of obese adults, that include type 2-diabetes, dyslipidemia and hypertension. Also environmental factors, such as reduced physical activity and increased sedentary activities, may also result in increased caloric intake and/or decreased caloric expenditure. In the present review, we aimed to identify and describe a specific panel of parameters in order to evaluate and characterize the childhood obesity status useful in setting up a preventive diagnostic approach directed at improving health-related behaviors and identifying predisposing risk factors. An early identification of risk factors for childhood obesity could definitely help in setting up adequate and specific clinical treatments.

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“…Obesity during childhood or adolescence increases the risk of atherosclerosis, cardiovascular disease, type 2 diabetes, hypertension, some cancers, and obesity in adulthood [2][3][4][5]. Early life adiposity patterns are strong risk factors for adolescent and adult obesity and cardiometabolic disease [6][7][8][9][10][11][12][13][14][15][16]. Later age and higher magnitude of infancy body mass index (BMI) zenith has been associated with excess adiposity and increased risk of obesity in adolescents and adults [8,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological studies suggest that gestational PFAS exposure is associated with decreased fetal growth [32,33], alterations in infant or childhood growth [34,35], and increased adiposity during infancy, childhood, and adulthood [35][36][37][38][39][40]. However, we are unaware of studies examining whether gestational PFAS exposure is associated with childhood adiposity patterns related to later life obesity or cardiometabolic disease, namely higher infancy BMI zenith, earlier BMI nadir, or accelerations in BMI accrual during childhood and adolescence [7][8][9][10][11][12][13]. Thus, we used a prospective cohort study to investigate whether maternal serum concentrations of four PFAS were associated with features of BMI patterns from age 4 weeks to 12 years in 345 children from Cincinnati, Ohio.…”

Section: Introductionmentioning

confidence: 99%

Gestational perfluoroalkyl substance exposure and body mass index trajectories over the first 12 years of life

et al. 2020

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Background/objectives Gestational exposure to perfluoroalkyl substances (PFAS), a ubiquitous class of persistent endocrine disrupting chemicals, is associated with increased risk of obesity and cardiometabolic disease. However, it is unclear if gestational PFAS exposure is associated with adiposity trajectories related to adult obesity and cardiometabolic health. Subjects/methods We measured perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononaoic acid, and perfluorohexanesulfonic acid (PFHxS) concentrations in maternal serum collected between 16 weeks gestation and delivery in a cohort of 345 mother-child pairs in Cincinnati, OH (enrolled 2003-06). From age 4 weeks to 12 years, we measured weight and length or height up to eight times and calculated child body mass index (BMI) (1865 repeated measures). Using covariate-adjusted linear mixed models and splines to account for repeated BMI measures and nonlinear BMI patterns, respectively, we estimated the age/magnitude of infancy BMI zenith (~1 year) and childhood BMI nadir (~5 years), BMI accrual from 8 to 12 years, and BMI at age 12 years by PFAS terciles. Results BMI trajectories varied by PFOA concentrations (age × PFOA interaction p value = 0.03). Children born to women with higher PFOA concentrations had lower infancy and early childhood BMI, earlier BMI nadir, accelerating BMI gains in mid-childhood and adolescence, and higher BMI at age 12 years. Some of these associations were non-monotonic. PFOS and PFHxS were not associated with alterations in BMI trajectories, but were monotonically associated with lower BMI across infancy, childhood, and adolescence. Compared to children in the first PFOS tercile, those in the second (β: −0.83; 95% confidence interval (CI): −2.11, 0.51 kg/m 2), and third (β: −1.41; 95% CI: −2.65, −0.14 kg/m 2) had lower BMI at age 12 years. Conclusions These results suggest that gestational PFOA exposure may be associated with BMI trajectories related to adult obesity and cardiometabolic disease, while PFOS and PFHxS exposure is associated with lower BMI in the first 12 years of life.

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Change in body mass index from childhood onwards and risk of adult cardiovascular disease,

Cited by 41 publications

References 39 publications

The Exposome in Human Evolution: From Dust to Diesel

The Exposome in Human Evolution: From Dust to Diesel

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Gestational perfluoroalkyl substance exposure and body mass index trajectories over the first 12 years of life

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