Abstract:Background: Chang-Kang-Fang formula (CKF), a multi-herb traditional Chinese medicinal formula, has been clinically used for treatment of irritable bowel syndrome with diarrhea (IBS-D). Though we have reported the compounds of CKF and the therapeutic effect on IBS-D rats, the exact mechanism underlying is still not clear. The aim of this study is to clearly define the effect of CKF on IBS-D by regulating gut microbiota and gut-brain axis.Method: We investigated the effects of CKF on IBS-D rat model, established… Show more
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