Challenging the Serotonin System: A Mechanistic Approach to the Method of Acute Tryptophan Depletion in Rodents

Abstract

People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

Translational research from a developmental viewpoint – Embarking on a neuroscientific journey

“…In addition, the journal features the abstracts and captured talks (provided as video files) of a symposium entitled ''Stimulating New Research on Serotonergic Neurotransmission from a Developmental Perspective'', which took place in Aachen, Germany. Presented topics include the use of depletion techniques related to 5-HT in children and adolescents (10) as well as the use of acute tryptophan depletion in rodents (11,12) and adults (13,14) to study the effects of 5-HT on behavioral inhibition (15), resting state MRI and antidepressant drug action (16), and the effects of TRP challenge on mood and coping with stress (17). With the first set of publications in TDP targeting the age groups outlined in the journal's aims and scope as indexed by infancy (2) and placental metabolism (3), childhood (10), and adolescence (10,15) as well as research conducted in adults (13,14) and animal research (9,11,12,15), I believe that this issue provides a good example of what to expect from TDP in the future.…”

“…Presented topics include the use of depletion techniques related to 5-HT in children and adolescents (10) as well as the use of acute tryptophan depletion in rodents (11,12) and adults (13,14) to study the effects of 5-HT on behavioral inhibition (15), resting state MRI and antidepressant drug action (16), and the effects of TRP challenge on mood and coping with stress (17). With the first set of publications in TDP targeting the age groups outlined in the journal's aims and scope as indexed by infancy (2) and placental metabolism (3), childhood (10), and adolescence (10,15) as well as research conducted in adults (13,14) and animal research (9,11,12,15), I believe that this issue provides a good example of what to expect from TDP in the future. It is a great time to work in the field of developmental neuroscience, and I hope that TDP can contribute successfully to an exciting neuroscientific journey.…”