Challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development

Regulatory experience with the mouse local lymph node assay for skin sensitisation

“…An initial data sharing exercise on the approaches used within individual companies indicated significant scope for reduction through harmonisation (Robinson et al, 2005). The aim of the working group is to facilitate co-operation and data sharing on conventional acute toxicity studies, and to review how acute toxicity data are gathered and used across the pharmaceutical industry.…”