Taking global marine change as its point of departure, this chapter argues that we now need to devise knowledge that will not only help us monitor that change in the future, but also provide the basis for appropriate and wise action. Knowledge comes in many different forms and different types of knowledge are social-ecological products. Because there is no such thing as the view from nowhere and because all knowledge is patchy and partial, future knowledge producers need to be more reflexive about their own social-ecology and that of the knowledge they produce. Stronger institutional support for the collaborative production of knowledge is needed to help us cut across not only disciplinary divides but, also the gaps between expert, or local and critical knowledge, that have hampered understanding and the use of knowledge for wise action. But the power dynamics of those institutions cannot be ignored and some boundaries are essential if we are to avoid the collapse of interrogation and investigation into politics.