Challenges with hepatitis B vaccination of high risk adults – A pilot program

Bridges, Carolyn B.; Watson, Tureka; Nelson, Noele P.; Chavez-Torres, Maribel; Fineis, Patrick; Ntiri-Reid, Boatemaa; Wake, Edward; Leahy, Judith M.; Kurian, Anita K.; Hall, Mary Ann Kirkconnell; Kennedy, Erin D.

doi:10.1016/j.vaccine.2019.05.089

Cited by 15 publications

(22 citation statements)

References 23 publications

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“…From 2013 to 2015, the WV Pilot Project administered over 10,000 doses of HBV vaccine to adults considered at risk for HBV infection in 18 counties. At-risk adults were reached through local health department STD clinics, correctional facilities, substance use treatment centers, and HIV care facilities ( Bridges et al, 2019 ; West Virginia Office of Epidemiology and Prevention Services, 2015 ). Completion of the three-dose series was cited as a challenge throughout the project ( West Virginia Office of Epidemiology and Prevention Services, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

“…In January 2013, the West Virginia Bureau for Public Health, Office of Epidemiology and Prevention Services (WV OEPS) initiated the West Virginia Hepatitis B Vaccination Pilot Program (WV Pilot Project), part of a larger CDC funded HepB Vaccine Pilot Program implemented in 14 local and state health departments nationwide ( Bridges et al, 2019 ). The goal of the two-year project in WV was to decrease the number of new HBV infections by providing over 10,000 doses of vaccine to at-risk adults in 18 counties with higher rates of acute hepatitis B ( Harris et al, 2016 ; West Virginia Office of Epidemiology and Prevention Services, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

“…The goal of the two-year project in WV was to decrease the number of new HBV infections by providing over 10,000 doses of vaccine to at-risk adults in 18 counties with higher rates of acute hepatitis B ( Harris et al, 2016 ; West Virginia Office of Epidemiology and Prevention Services, 2015 ). Vaccine was administered to adults considered at-risk for HBV infection at sites where universal HBV vaccination is recommended including HIV clinics, local health department (LHD) STD clinics, and LHD community partnerships with local substance use treatment centers and correctional facilities ( Bridges et al, 2019 ; West Virginia Office of Epidemiology and Prevention Services, 2015 ; Mast et al, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

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Impact of a vaccine intervention on county-level rates of acute hepatitis B in West Virginia, 2011–2018

Tressler

Smith

Hendricks

2020

Preventive Medicine

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The rate of acute hepatitis B in West Virginia (WV) has been increasing since 2006. To reduce new infections, WV implemented a vaccine intervention (WV Pilot Project), which provided over 10,000 doses of hepatitis B vaccine to at-risk adults in 18 counties. The objectives of this study were to describe yearly changes in acute hepatitis B incidence and assess county-level impact of the WV Pilot Project using geospatial methods. County rates of acute hepatitis B and vaccine doses per 100,000 population were visualized biannually from 2011 to 2018. Local indicators of spatial autocorrelation were used to detect county-level clustering. Significant differences in the median rate of acute hepatitis B pre and post intervention in counties receiving vaccine were evaluated using Wilcoxon signed-rank test and bootstrapping. A Bland-Altman graph visualized significant differences in county-level rates of acute hepatitis B before and after the WV Pilot Project compared to the statewide estimate. Analyses identified significant geographic clustering of acute hepatitis B in southern WV across all four time-periods. Nine of the 18 (50%) counties receiving vaccine had significant declines in acute hepatitis B incidence compared to the statewide mean difference estimate. Findings suggest that increased dissemination of hepatitis B vaccine through local health departments and existing harm reduction services can reduce the incidence of acute hepatitis B in states such as WV, which have been disproportionately affected by substance misuse.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of a vaccine intervention on county-level rates of acute hepatitis B in West Virginia, 2011–2018

Tressler

Smith

Hendricks

2020

Preventive Medicine

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“…Use of the 2-dose series in future vaccine interventions among PWID may increase adherence and result in a higher immune response compared with the traditional 3-dose series. However, results from a recent study indicated that the percentage of at-risk people completing the second dose of the traditional HBV vaccine series was only 40.4%, suggesting a need to incorporate strategies to increase HBV vaccine schedule adherence even for a 2-dose series [20].…”

Section: Discussionmentioning

confidence: 99%

Interventions to Increase Completion of Hepatitis B Vaccination in People who Inject Drugs: A Systematic Review and Meta-analysis

Tressler

Bhandari

2019

Open Forum Infectious Diseases

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Increases in opioid misuse and injection drug use have resulted in a rise in acute cases of hepatitis B. We conducted a systematic review and meta-analysis of randomized studies to determine the effect (pooled odds ratio) of interventions to increase hepatitis B vaccination completion in people who inject drugs (PWID). Odds ratios from the included studies were combined to create a pooled odds ratio (OR) using the Inverse Heterogeneity Model. Eleven studies met the eligibility criterion of having a randomized intervention to increase hepatitis B virus vaccination completion among PWID. The odds of vaccine completion in the intervention group were greater than in the control/comparison group (pooled OR, 2.53; 95% confidence interval [CI], 1.07–5.99). Subgroup analysis indicated that financial incentives were most effective (OR, 7.01; 95% CI, 2.88–17.06), followed by accelerated vaccine schedules (OR, 1.90; 95% CI, 1.14–3.14). Interventions using financial incentives and accelerated vaccine schedules are moderately effective at increasing hepatitis B vaccination completion in PWID.

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“…2,3 From 2012 to 2015, the Centers for Disease Control and Prevention (CDC) funded a vaccine pilot program in 14 state and local health departments, including WV, to reduce the number of new HBV infections in at-risk adults. 4 Adults were vaccinated in settings where universal vaccination is recommended and in specific settings where those with risk factors were typically seen or who were living in communities with an increased incidence of acute HBV infection. 4,5 As part of the national pilot program, the WV Hepatitis B Vaccination Pilot Program (WV Pilot Project) distributed more than 10,000 doses of HBV vaccine to the 18 counties with higher rates of acute HBV.…”

Section: Introductionmentioning

confidence: 99%

Variations in Hepatitis B Vaccine Series Completion by Setting Among Adults at Risk in West Virginia

Tressler

Lilly

Gross

et al. 2020

American Journal of Preventive Medicine

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Challenges with hepatitis B vaccination of high risk adults – A pilot program

Cited by 15 publications

References 23 publications

Impact of a vaccine intervention on county-level rates of acute hepatitis B in West Virginia, 2011–2018

Impact of a vaccine intervention on county-level rates of acute hepatitis B in West Virginia, 2011–2018

Interventions to Increase Completion of Hepatitis B Vaccination in People who Inject Drugs: A Systematic Review and Meta-analysis

Variations in Hepatitis B Vaccine Series Completion by Setting Among Adults at Risk in West Virginia

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