Challenges to environmental toxicology and epidemiology: where do we stand and which way do we go?

Pesch, Beate; Brüning, Thomas; Frentzel‐Beyme, Rainer; Johnen, Georg; Harth, Volker; Hoffmann, Wolfgang; Ko, Yon; Ranft, Ulrich; Traugott, U.; Thier, Ricarda; Taeger, Dirk; Bolt, Hermann M.

doi:10.1016/j.toxlet.2004.02.020

Cited by 22 publications

(12 citation statements)

References 65 publications

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“…World Health Organization statistics report that 80% of human diseases are related to environmental pollution (Pesch et al, 2004;Neubert, 2002;Zhanfen and Xiaobai, 2006). In recent years, there are increasing reports on endocrine disorder, reproductive dysfunction, sexual reversal, environmental deterioration and biodiversity alteration.…”

Section: Introductionmentioning

confidence: 99%

Amphibians as Model Organisms for Study Environmental Genotoxicity

Burlibaşa¹

2011

Appl Ecol Env Res

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Abstract. Animals, the silent sentinels, stand watch over the world's environmental health. Everyday, animals demonstrate intricate connections between them, us and our surroundings. Amphibians are vertebrates and include approximately 4400 existing species. Amphibians are in most cases, small, diverse and sensitive to environmental variability. They can be good indicators of habitat diversity, biological variety and local stressors on the environment. They are bathed in both water and air. They live outdoors on land and water and their skin, larvae and unshelled eggs are constantly exposed and in contact with the substances in their surroundings. We searched Web of Science and references of relevant publications to evidence the application of amphibians, especially Xenopus laevis as model animal in ecotoxicology.

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Section: Introductionmentioning

confidence: 99%

Amphibians as Model Organisms for Study Environmental Genotoxicity

Burlibaşa¹

2011

Appl Ecol Env Res

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“…Therefore, the sensitivity of metamorphic development to thyroid hormones and endocrine disruptors with thyroid disrupting activity enables X. laevis to be used to study thyroid disruption of environmental substances. Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) of the US Environmental Protection Agency recommended that X. lavis tail resorption test be used to valuate thyroid dis-ruption of endocrine disruptors 1) . So far, several laboratories have used X. laevis to valuate thyroid disruption of environmental pollutants [50,51] .…”

Section: Sensitivity To Thyroid Hormone and Thyroid Disruptormentioning

confidence: 99%

“…According to WHO statistics, 80% of human diseases are related to environmental pollution [1,2] . Especially in recent years, there are increasing reports on endocrine disorder, reproductive dysfunction, sexual reversal, ecoenvironmental deterioration, biodiversity reduction, and so on.…”

mentioning

confidence: 99%

Application of Xenopus laevis in ecotoxicology (I) —Introduction and quality control of laboratory animal

Qin

2006

CHINESE SCI BULL

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The aim of the series of papers is to discuss the application of Xenopus laevis, as model animal in biology, in ecotoxicology. X. laevis as model animal is wildly used in biological study and has provided a lot of relating data because of many advantages, such as living in water and being easily maintained, laying eggs in the whole year, and externally fertilizing and developing. Embryos and larvae of X. laevis like other amphibians are directly exposed in the aquatic environment and sensitive to pollutants. In addition, sex differentiation and sex organ development of X. laevis are sensitive to sex hormones and endocrine disruptors with sex hormone activities, which enable X. laevis to be used in studies on sex hormone disruption and reproductive toxicity of endocrine disruptors. Metamorphic development of X. laevis is very sensitive to thyroid hormones and thyroid disruptors, which enables X. laevis to be used for evaluating thyroid disruptors. Also, X. laevis ecotoxicology can be linked with amphibian population declines and malformed frog occurrence, being one of the hotspots in ecology. Thus, more and more laboratories have introduced X. laevis to ecotoxicological study. The quality of laboratory animals correlates with scientificity and reliability of results from animal experiments. It is especially important for toxicology. Quality control of X. laevis involving several factors such as water and food is discussed in this paper.

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“…The use of genomics data in the evaluation of health hazards and risks has received considerable attention focusing on priority setting (Pesch et al 2004), biomarker identification (Toraason et al 2004), hazard identification (Suter et al 2004), and dose-response analysis (Schonwalder and Olden 2003;Simmons and Portier 2002;Waters et al 2003). If genomics is to play a direct role in dose-response assessment, there will be a need for methods that provide a direct, quantitative assessment of changes in gene expression as a function of dose and changes in toxicity as a function of changes in gene expression.…”

Section: Toxicogenomics | Articlementioning

confidence: 99%

The TAO-Gen Algorithm for Identifying Gene Interaction Networks with Application to SOS Repair in E. coli

Yamanaka¹,

Toyoshiba²,

Sone³

et al. 2004

Environ Health Perspect

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One major unresolved issue in the analysis of gene expression data is the identification and quantification of gene regulatory networks. Several methods have been proposed for identifying gene regulatory networks, but these methods predominantly focus on the use of multiple pairwise comparisons to identify the network structure. In this article, we describe a method for analyzing gene expression data to determine a regulatory structure consistent with an observed set of expression profiles. Unlike other methods this method goes beyond pairwise evaluations by using likelihood-based statistical methods to obtain the network that is most consistent with the complete data set. The proposed algorithm performs accurately for moderate-sized networks with most errors being minor additions of linkages. However, the analysis also indicates that sample sizes may need to be increased to uniquely identify even moderate-sized networks. The method is used to evaluate interactions between genes in the SOS signaling pathway in Escherichia coli using gene expression data where each gene in the network is over-expressed using plasmids inserts.

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Challenges to environmental toxicology and epidemiology: where do we stand and which way do we go?

Cited by 22 publications

References 65 publications

Amphibians as Model Organisms for Study Environmental Genotoxicity

Amphibians as Model Organisms for Study Environmental Genotoxicity

Application of Xenopus laevis in ecotoxicology (I) —Introduction and quality control of laboratory animal

The TAO-Gen Algorithm for Identifying Gene Interaction Networks with Application to SOS Repair in E. coli

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