Challenges of the Omicron (B.1.1.529) Variant and Its Lineages: A Global Perspective

Mohapatra, Ranjan K.; Ramana, K V; Verma, Sarika; Dhama, Kuldeep

doi:10.1002/cbic.202200059

Cited by 37 publications

(33 citation statements)

References 32 publications

(42 reference statements)

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Section: Introductionmentioning

confidence: 99%

“…BA.2 lineage has 32 mutations shared with BA.1, but 28 distinct, and BA.3 spike protein is a combination of BA.1 and BA.2 with no new mutations. The most prevalent is the BA.1 sublineage, while BA.2 has been observed to reinfect patients previously infected with BA.1, being more prevalent in Denmark (Chen and Wei 2022; Mohapatra, Kandi et al 2022; Desingu and Nagarajan, 2022). Shortly after the SARS-CoV-2 virus entered our lives, field studies on the incidence in animals, as well as experimental studies, began to be carried out to learn about their role in this new disease (Shi, Wen et al 2020).…”

Section: Introductionmentioning

confidence: 99%

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The Omicron (B.1.1.529) SARS-CoV-2 variant of concern also affects companion animals

Sánchez-Morales

Sánchez‐Vizcaíno

Domı́nguez

et al. 2022

Preprint

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The recent emergence of the Omicron variant (B.1.1.529) has brought with it a large increase in the incidence of SARS-CoV-2 disease worldwide. However, there is hardly any data on the incidence of this new variant in companion animals. In this study, we have detected the presence of this new variant in domestic animals such as dogs and cats living with owners with COVID19 in Spain that have been sampled at the most optimal time for the detection of the disease. None of the RT-qPCR positive animals (10.13%) presented any clinical signs and the viral loads detected were very low. In addition, the shedding of viral RNA lasted a short period of time in the positive animals. Infection with the Omicron variant of concern (VOC) was confirmed by a specific RT-qPCR for the detection of this variant and by sequencing. These outcomes suggest a lower virulence of this variant in infected cats and dogs. This study demonstrates the transmission of this new variant from infected humans to domestic animals and highlights the importance of doing active surveillance as well as genomic research to detect the presence of VOCs or mutations associated with animal hosts.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Omicron (B.1.1.529) SARS-CoV-2 variant of concern also affects companion animals

Sánchez-Morales

Sánchez‐Vizcaíno

Domı́nguez

et al. 2022

Preprint

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“…More recently, another Omicron subvariant (BA.2) was reported in Denmark, and Fonager et al found significant differences in the mutation analysis of BA.1 and BA.2 ( 8 ). Subsequent studies revealed that BA.2 is substantially more transmissible and possesses a higher immune-evasive ability than BA.1 ( 9 ). Few patients infected with Omicron BA.2 progressed to severe cases, but some of them were transferred to ICU and died ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Case Report: The Experience of Managing a Moderate ARDS Caused by SARS-CoV-2 Omicron BA.2 Variant in Chongqing, China: Can We Do Better?

Peng

Dong

et al. 2022

Front. Med.

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BackgroundThe severe coronavirus disease 2019 (COVID-19) pandemic is still raging worldwide, and the Omicron BA.2 variant has become the new circulating epidemic strain. However, our understanding of the Omicron BA.2 variant is still scarce. This report aims to present a case of a moderate acute respiratory distress syndrome (ARDS) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron BA.2 variant and to discuss some management strategies that may benefit this type of case.Case PresentationA 78-year-old man, who had four negative nucleic acid tests and a fifth positive, was admitted to our hospital. This patient was generally good upon admission and tested negative for anti-SARS-CoV-2 antibodies even after receiving two doses of the COVID-19 vaccine. On the 7th day of hospitalization, he developed a moderate ARDS. Improved inflammatory index and decreased oxygen index were primarily found in this patient, and a series of treatments, including anti-inflammation and oxygen therapies, were used. Then this patient’s condition improved soon and reached two negative results of nucleic acid tests on the 18th day of hospitalization.ConclusionAt-home COVID-19 rapid antigen test could be complementary to existing detection methods, and the third booster dose of COVID-19 vaccine may be advocated in the face of the omicron BA.2 variant. Anti-inflammatory and oxygen therapies are still essential treatments for ARDS patients infected with SARS-CoV-2 Omicron BA.2 variant.

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“…The omicron was first reported by South African scientists and the initial observations were that the virus is extremely transmissible and causes less severe infections than the delta infections [ 4 ]. Surprisingly, the Omicron variant developed into several sublineages, and more recently, recombinants formed from delta and omicron and omicron sublineages have been continuously emerging [ 5 ]. The omicron variant and its sublineages have been noted to be increasingly transmissible than the previous variants and have the potential to evade immune responses and be resistant to monoclonal antibody therapy [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of SARS-CoV-2 Infected Patients and Their Clinical Outcomes During the Third Wave in India: A Single-Center Observational Study

Shahapur¹,

Shahapur²,

Kandi³

et al. 2022

Cureus

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BackgroundThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that emerged from the Chinese mainland has spread throughout the world affecting the normal lives of the people. Both developed and developing nations have been equally affected and coronavirus disease-19 (COVID-19) resulted in the death of millions of people worldwide. The virus is undergoing mutations and is evolving into variants that are responsible for wave after wave. This study was carried out to assess the clinical outcomes of people infected with the novel virus during the third wave of the COVID-19 pandemic in India. MethodsThe study was carried out between November 2021 and January 2022 and included 100 consecutive patients attending the hospital attached to the BLDE (Deemed to

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Challenges of the Omicron (B.1.1.529) Variant and Its Lineages: A Global Perspective

Abstract: The SARS-CoV-2 virus has shown increased ability to mutate over the past two years, especially in the regions of the spike protein and receptor binding sites. Omicron (B.1.1.529) is the fifth variant of concern (VOC) after the emergence of the Alpha,

Cited by 37 publications

References 32 publications

The Omicron (B.1.1.529) SARS-CoV-2 variant of concern also affects companion animals

The Omicron (B.1.1.529) SARS-CoV-2 variant of concern also affects companion animals

Case Report: The Experience of Managing a Moderate ARDS Caused by SARS-CoV-2 Omicron BA.2 Variant in Chongqing, China: Can We Do Better?

Assessment of SARS-CoV-2 Infected Patients and Their Clinical Outcomes During the Third Wave in India: A Single-Center Observational Study

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