Challenges of the newer generation of resorbable magnesium scaffolds: Lessons from failure mechanisms of the past generation

Seguchi, Masaru; Aytekin, Alp; Lenz, Tobias; Nicol, Philipp; Alvarez-Covarrubias, Hector A.; Xhepa, Erion; Klosterman, Grace R; Beele, Alicia; Sabic, Emina; Utsch, Léa; Joner, Michael

doi:10.1016/j.jjcc.2022.09.003

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Klinik Für Herz-und Kreislauferkrankungen Deutsches Herzzent...1

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2023

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Cited by 3 publications

(1 citation statement)

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“…However, the results of clinical trials have been disappointing, demonstrating an increased risk of scaffold thrombosis and restenosis 1,2 . Despite this setback, research and development efforts to improve the safety and efficacy of BRS continue, with a focus on several directions including strut thickness and scaffold material 3 . Another promising option may be to modify the strut shape to round struts, which has the potential to improve the blood flow characteristics in coronary arteries.…”

Section: Klinik Für Herz-und Kreislauferkrankungen Deutsches Herzzent...mentioning

confidence: 99%

New opportunities for bioresorbable scaffold technology

Kastrati,

Seguchi

2023

AsiaIntervention

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Section: Klinik Für Herz-und Kreislauferkrankungen Deutsches Herzzent...mentioning

confidence: 99%

New opportunities for bioresorbable scaffold technology

Kastrati,

Seguchi

2023

AsiaIntervention

Self Cite

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Negative findings but positive contributions in cardiovascular research

Chen

Zeng

2023

Life Sciences

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The Effects of Sirolimus and Magnesium on Primary Human Coronary Endothelial Cells: An In Vitro Study

Fedele

Castiglioni

Maier

et al. 2023

IJMS

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Drug eluting magnesium (Mg) bioresorbable scaffolds represent a novel paradigm in percutaneous coronary intervention because Mg-based alloys are biocompatible, have adequate mechanical properties and can be resorbed without adverse events. Importantly, Mg is fundamental in many biological processes, mitigates the inflammatory response and is beneficial for the endothelium. Sirolimus is widely used as an antiproliferative agent in drug eluting stents to inhibit the proliferation of smooth muscle cells, thus reducing the occurrence of stent restenosis. Little is known about the potential interplay between sirolimus and Mg in cultured human coronary artery endothelial cells (hCAEC). Therefore, the cells were treated with sirolimus in the presence of different concentrations of extracellular Mg. Cell viability, migration, barrier function, adhesivity and nitric oxide synthesis were assessed. Sirolimus impairs the viability of subconfluent, but not of confluent cells independently from the concentration of Mg in the culture medium. In confluent cells, sirolimus inhibits migration, while it cooperates with Mg in exerting an anti-inflammatory action that might have a role in preventing restenosis and thrombosis.

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Challenges of the newer generation of resorbable magnesium scaffolds: Lessons from failure mechanisms of the past generation

Cited by 3 publications

References 55 publications

New opportunities for bioresorbable scaffold technology

New opportunities for bioresorbable scaffold technology

Negative findings but positive contributions in cardiovascular research

The Effects of Sirolimus and Magnesium on Primary Human Coronary Endothelial Cells: An In Vitro Study

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