ObjectiveWe aimed to investigate the medical characteristics of helicopter hoist operations (HHO) in HEMS missions.MethodsWe designed a retrospective study evaluating all HHO and other human external cargo (HEC) missions performed by Swiss Air-Rescue (Rega) from 1 January 2010 to 31 December 2019.ResultsDuring the study period, 9,963 (88.7%) HEMS missions with HHO and HEC were conducted during the day, and 1,265 (11.3%) at night. Of the victims with time-critical injuries (NACA ≥4), 21.1% (n=400) reached the hospital within 60 min during the day, and 9.1% (n=18) at night. Nighttime missions, a trauma diagnosis, intubation on-site, and NACA Score ≥4were independently and highly significantly associated with longer mission times (p<0.001). The greatest proportion of patients, who needed hoist or HEC operations in the course of the HEMS mission during daytime, sustained moderate injuries (NACA 3, n=3,731, 37.5%) while practicing recreational activities (n=5,492, 55.1%). In daytime HHO missions, the most common medical interventions performed were an insertion of a peripheral intravenous access (n=3,857, 38.7%) and administration of analgesia (n=3,121, 31.3%). ConclusionsNearly 20% of patients, who needed to be evacuated by a hoist, were severely injured, and complex and lifesaving medical interventions were necessary before the HHO procedure. Therefore, only adequately trained and experienced medical crew members should accompany HHO missions.