Challenges of gene delivery to the central nervous system and the growing use of biomaterial vectors

Puhl, Devan L; D’Amato, Anthony R.; Gilbert, Ryan J.

doi:10.1016/j.brainresbull.2019.05.024

Cited by 42 publications

(27 citation statements)

References 177 publications

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“…The main aims of these delivery strategies include enhancing transduction efficiency (TE), long-term release of VPs, reduction of Table 1 Overview of most common VVs for gene delivery studies immune response, broadening of tropism and targeted delivery. 6,67…”

Section: Limitationsmentioning

confidence: 99%

Materials promoting viral gene delivery

Kaygisiz

Synatschke

2020

Biomater. Sci.

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Section: Limitationsmentioning

confidence: 99%

Materials promoting viral gene delivery

Kaygisiz

Synatschke

2020

Biomater. Sci.

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“…5,6 However, the disadvantages of non-viral vectors are poorer brain targeting and lower transfection efficiency for therapy of central nervous system diseases. 7 To improve brain targeting, the penetration efficiency of the BBB should be improved rst. The BBB mainly comprises the brain capillary endothelial cells and other different types of cells, like pericytes and astrocytes, that also contribute to the formation of the BBB.…”

Section: Introductionmentioning

confidence: 99%

A brain glioma gene delivery strategy by angiopep-2 and TAT-modified magnetic lipid-polymer hybrid nanoparticles

et al. 2020

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“…Gene therapy is hopeful and encouraging for the remedy of neurological disorders or CNS injury [163]. However, gene therapy of cerebral diseases is confined owing to the void of a secure and efficient gene delivery system that can penetrate the BBB, thereby reaching the brain cells after intravenous administration.…”

Section: Brain Gene Delivery With Dendrimersmentioning

confidence: 99%

Dendrimer-Based Drug Delivery Systems for Brain Targeting

2019

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Human neuroscience has made remarkable progress in understanding basic aspects of functional organization; it is a renowned fact that the blood–brain barrier (BBB) impedes the permeation and access of most drugs to central nervous system (CNS) and that many neurological diseases remain undertreated. Therefore, a number of nanocarriers have been designed over the past few decades to deliver drugs to the brain. Among these nanomaterials, dendrimers have procured an enormous attention from scholars because of their nanoscale uniform size, ease of multi-functionalization, and available internal cavities. As hyper-branched 3D macromolecules, dendrimers can be maneuvered to transport diverse therapeutic agents, incorporating small molecules, peptides, and genes; diminishing their cytotoxicity; and improving their efficacy. Herein, the present review will give exhaustive details of extensive researches in the field of dendrimer-based vehicles to deliver drugs through the BBB in a secure and effectual manner. It is also a souvenir in commemorating Donald A. Tomalia on his 80th birthday.

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Challenges of gene delivery to the central nervous system and the growing use of biomaterial vectors

Cited by 42 publications

References 177 publications

Materials promoting viral gene delivery

Materials promoting viral gene delivery

A brain glioma gene delivery strategy by angiopep-2 and TAT-modified magnetic lipid-polymer hybrid nanoparticles

Dendrimer-Based Drug Delivery Systems for Brain Targeting

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