Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity – A review

Wu, Shouyan; Wang, Yajing; Iqbal, Mujahid; Mehmood, Khalid; Liu, Ying; Tang, Zhaoxin; Zhang, Hui

doi:10.1016/j.envpol.2022.119241

Cited by 81 publications

(29 citation statements)

References 107 publications

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“…Hence, it has important practical significance to explore the toxicity mechanism of fluoride-induced hepatic injury and search effective preventive and cure measures for the health and the sustainable development of humans and animals. It has become a hotspot in public health to search effective measures to prevent and treat fluorosis …”

Section: Introductionmentioning

confidence: 99%

“…In addition, fluoride accumulates in the human body through the food chain, causing serious harm to humans . Long-term fluoride exposure can cause damage to the structure and function of multiple organs in the body . Among them, the liver, as the main metabolic organ, is the critical hub for the maintenance of oxidative balance, the regulation of the metabolism of three major nutrients, the replenishment of the immune system, the regulation of lipid and cholesterol homeostasis, and the catabolism of drugs and poisons. , Studies have found that fluoride could affect metabolic function, reduce detoxification ability, and cause metabolic disorders in the liver .…”

Section: Introductionmentioning

confidence: 99%

“…Fluorinated pesticides and packaging materials are widely used in agricultural production and food packaging, respectively. 1 Water and food are highly susceptible to fluoride contamination because fluoride is readily soluble in water. In addition, fluoride accumulates in the human body through the food chain, causing serious harm to humans.…”

Section: ■ Introductionmentioning

confidence: 99%

“…It has become a hotspot in public health to search effective measures to prevent and treat fluorosis. 1 Ferroptosis is a novel iron-dependent programmed cell death distinct from autophagy, necrosis, and apoptosis. 8 The main ultrastructural features of ferroptosis are smaller mitochondria, increased membrane density, decreased/dis-appeared cristae density, plasma membrane blebbing, and increased cytoplasmic and lipid peroxidation.…”

Section: ■ Introductionmentioning

confidence: 99%

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α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis

Zhao

Liu

Liang

et al. 2022

J. Agric. Food Chem.

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Fluoride is widely used in agricultural production and food packaging. Excessive fluoride in water and food is a serious threat to liver health. α-Lipoic acid, a natural free radical scavenger, has hepatoprotective properties. However, the protective effect of α-lipoic acid on fluorohepatotoxicity is uncertain. The aim of this study was to investigate the mechanism of ferroptosis in α-lipoic acid preventing fluoride-induced hepatotoxicity. Five-week-old ICR mice were treated with sodium fluoride (100 mg/L) and/or α-lipoic acid (200 mg/kg) for 9 weeks. The results showed that α-lipoic acid attenuated fluoride-induced damage to liver morphology and ultrastructure. Moreover, α-lipoic acid alleviated fluoride-induced iron accumulation, increased oxidative stress, and elevated lipid peroxidation in the liver. In addition, the mechanism study found that α-lipoic acid prevented fluoride-induced ferroptosis through the System Xc–/GPX4 axis, lipid peroxidation axis, and iron metabolism axis, but it was interestingly not regulated by mitochondrial free radical axis in the hepatocytes. Altogether, this study indicated that α-lipoic acid prevents fluoride-induced liver injury by inhibiting ferroptosis, which has potential implications for the prevention and treatment of fluoride-induced liver injury.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 2 more Smart Citations

α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis

Zhao

Liu

Liang

et al. 2022

J. Agric. Food Chem.

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“…Fluoride in water has long been a matter of concern mainly because of the local health risks posed by excessive intake of fluoride. Scholarly attention to this issue has also mainly focused on the source and enrichment mechanism of fluoride in groundwater, along with health risk assessment (Ozsvath, 2009;Ghosh et al, 2013;Feng et al, 2020;Liu et al, 2021;Masood et al, 2022;Wu et al, 2022). Recent research has found high fluoride levels in groundwater widely distributed in the north, northeast, and northwest regions of China, mainly in shallow groundwater (He et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Sources and migration characteristics of fluorine in the river water of a small karst watershed influenced by coal mining

Huang

et al. 2022

Front. Environ. Sci.

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In high-fluorine geological background areas, the supergene geochemical process of fluorine has an impact on regional environmental health and safety, which has long been the focus of attention. However, in karst areas characterized by a high incidence of endemic fluorosis, the migration and transformation of fluorine in surface water have not received sufficient attention. This study investigated the joint influence of the weathering and erosion of carbonate rocks and coal-bearing strata on a typical small watershed. Accordingly, 239 samples representing 13 periods of hydrochemical samples were systematically collected to clarify the source, migration, and transformation characteristics of fluorine in surface water. The results revealed that the pH of the Huatan River was low in the rainy season and high in the dry season. The annual variation range of fluorine concentration was 0.11–0.40 mg/L. Although mining development produced acid mine drainage with high fluorine concentration, its impact at the watershed scale appeared to be limited. In terms of spatial scale, the concentration of fluorine in the Huatan River increased gradually from upstream to downstream. The dissolution of fluorite and other fluorine-bearing minerals had not reached the saturation state. The fluorine in the watershed primarily came from the dissolution of fluorine-bearing minerals, followed by the contribution of atmospheric precipitation. The release of fluorine adsorbed on the surface of clay minerals was not the main source of this element. The leaching of the watershed was shown to represent a critical transport process concerning fluorine in the Huatan River, and evaporation had a notable impact on the enrichment of fluorine in water.

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Choline alleviated perinatal fluoride exposure‐induced learning and memory impairment through α4β2 nAChRs and α7 nAChRs in offspring mice

Zhao

Wang

2022

Environmental Toxicology

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Fluoride pollution is widely present in the living environment. As a critical period of brain development, the perinatal period is extremely vulnerable to fluoride. Studies have found that choline can protect the brain's memory and enhance the ability to focus. However, the effect of choline on perinatal fluoride-induced nerve damage remains unclear. Therefore, 32 Kunming newly conceived female mice and their offspring mice were randomly divided into control, NaF, LC + NaF, and HC + NaF groups, and the HE staining, Y-maze test, RT-PCR, western blotting, immunohistochemistry, etc. were used in this study. The results showed that fluoride decreased the brain organ coefficients and brain protein content (p < 0.05, p < 0.01), and caused histomorphological damage in the hippocampus and cortex, which suggested that fluoride affected the development of the brain and damaged the brain. Moreover, the results of the Y-maze test showed that fluoride increased the number of learning days, error reaction time, and total reaction time, and decreased the AchE activity in the brain (p < 0.05, p < 0.01), which indicated that fluoride reduced the learning and memory ability of the mice. Besides, the results showed that fluoride decreased the mRNA and protein expression levels of α4β2 nAChRs and α7 nAChRs in the hippocampus and cortex (p < 0.05, p < 0.01). However, perinatal choline supplementation reversed the aforementioned fluoride-induced changes. In short, these results demonstrated that choline alleviated perinatal fluoride-induced learning and memory impairment, which will provide a rationale for the mitigation and prevention of fluoride-induced brain damage.

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Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity – A review

Cited by 81 publications

References 107 publications

α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis

α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis

Sources and migration characteristics of fluorine in the river water of a small karst watershed influenced by coal mining

Choline alleviated perinatal fluoride exposure‐induced learning and memory impairment through α4β2 nAChRs and α7 nAChRs in offspring mice

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