Challenges in the provision of skin in the UK: the use of human deceased donor skin in burn care relating to mass incidents in the UK

Horner, Chris; Crighton, Emilia; Dziewulski, Peter

doi:10.1007/s10561-013-9374-0

Cited by 3 publications

(5 citation statements)

References 26 publications

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“…The literature paid attention to the important role of allogeneic human skin collected from a deceased donor during the therapy for extensive and deeply burned victims of a mass catastrophe (Brown and Fryer 1954 ; Horner et al 2013 ).…”

Section: Resultsmentioning

confidence: 99%

“…Many authors have emphasized that the allogeneic human skin graft materials collected from a deceased donor play significant role in the therapy of heavily (extensive and deeply) burned casualties of a mass catastrophe (Brown and Fryer 1954 ; Horner et al 2013 ). Additionally, it could be remarked that human allogeneic skin graft materials may be the source of the collagenous biomaterials that are produced and evaluated in terms of tissue engineering.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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The urgent need to achieve an optimal strategic stock of human allogeneic skin graft materials in case of a mass disaster in Poland

et al. 2022

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A burn is a sudden injury which immediate or long-term consequences may be life-threatening for the patient. A mass disaster event may involve large numbers of severely burned patients. Patients of this type typically have a limited area of healthy, unburned skin from which an autologous split thickness skin graft could be collected. In a clinical situation of this type, it is necessary to use a particular skin substitute. Non-viable allogeneic human skin graft materials might be considered as the most suitable skin substitutes in the treatment of such patients. At present, Poland does not have a sufficient supply of human allogeneic skin graft materials to meet the needs arising from a sudden and unforeseen mass disaster. This study involved an analysis of selected mass disasters. From this an estimate was made from a verified casualty profile of the necessary minimum stock of human allogeneic skin graft materials. An insufficient amount of skin results from an inadequate number of skin donors, which in turn results from the current tissue donation system. Therefore, a proposal has been made for the organizational, legal and systemic changes required to improve the situation in Polish transplantology, with particular emphasis on skin donation. In order to achieve a strategic stock of human skin grafts, a tissue collecting transplantation team should be organized. The rights and obligations of the non-physician transplant team member should be extended. Proposals have been made for awareness campaigns (adverts, posters etc.) and educational schemes (educational video, lectures during transplant coordinator training, etc.). Finally, a proposal has been made for possible methods to deal with the logistic management of the allogeneic skin stock. The required, essential stock of human allogeneic skin in the event of a mass disaster has been estimated at 600,000 cm 2 . Supplementary Information The online version contains supplementary material available at 10.1007/s10561-022-10001-z.

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Section: Resultsmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

The urgent need to achieve an optimal strategic stock of human allogeneic skin graft materials in case of a mass disaster in Poland

et al. 2022

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“…Many authors have emphasized that the allogeneic human skin graft materials collected from a deceased donor play a significant role in the therapy of heavily (extensive and deeply) burned casualties of a mass catastrophe [ 20 , 21 ]. It can be pointed out that human allogeneic skin graft materials may be a source of the collagenous biomaterials that are produced and evaluated in terms of tissue engineering.…”

Section: Discussionmentioning

confidence: 99%

A Survey of 1000 Respondents on the Polish Population’s Knowledge and Attitudes about Tissue/Organ Donation and Transplantation in Times of Allogeneic Tissue Shortage

Hepa¹,

Łabuś²,

Gierek³

et al. 2022

IJERPH

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Tissue-engineered human allogeneic skin grafts retrieved from a deceased donor play an important role in the therapy of extensive and deeply burned patients. However, there is a vital deficit of allogeneic skin donors, and the reserves of human allogeneic skin grafts are not sufficient. The goal of this work was to analyze the level of knowledge and attitudes of Polish society in the field of transplantation, with particular emphasis on allogeneic skin transplantation. The study used a self-made questionnaire comprised of 23 questions. 1000 respondents took part in this research. The respondents were a diverse group in terms of age, sex, education, and place of residence. The obtained results show a general positive attitude of the respondents towards the idea of transplantology. However, people with lower education presented a more negative attitude towards the donation of tissues and organs. Additionally younger people were not able to clearly declare readiness for organ procurement. What is more data analysis revealed certain gaps in more detailed knowledge and surprising attitudes. In that respect, the lack of awareness about the criteria for determining brain death could be mentioned. There was also a lack of acceptance for skin procurement in specific population groups. It can therefore be concluded that a key role in the success of the idea of transplantation in Poland is the broad and systematic education of the society.

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“…36 Over the years, there has been an increase in the demand for skin allografts worldwide. [37][38][39] Since the foundation of the Donor Tissue Bank of Victoria (Melbourne, Australia) in 1994, the demand for skin allografts for the treatment of burns in Australia has steadily increased and demand always exceeded supply. 40 Being Australia's only operational skin bank for processing cryopreserved human cadaveric skin for the treatment of burns, there is a need to develop strategies to enable increased provision of skin allografts on a national level.…”

Section: Introductionmentioning

confidence: 99%

“…Over the years, there has been an increase in the demand for skin allografts worldwide 37–39 . Since the foundation of the Donor Tissue Bank of Victoria (Melbourne, Australia) in 1994, the demand for skin allografts for the treatment of burns in Australia has steadily increased and demand always exceeded supply 40 .…”

Section: Introductionmentioning

confidence: 99%

Organization of Hannover Skin Bank: Sterile culture and procurement protocols for viable cryopreserved allogeneic skin grafts of living donors

Schlottmann,

Strauß,

Ziesing

et al. 2023

International Wound Journal

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Preserved allogeneic donor skin still represents one of the gold standard therapies in temporary wound coverage in severely burned patients or chronic wounds. Allogeneic skin grafts are currently commercially available as cryo‐ or glycerol‐preserved allografts through skin tissue banks all over the world. Most of the skin tissue banks rely on human cadaveric skin donations. Due to the chronic shortage of human allogeneic transplants, such as skin, and increasing costs in the procurement of allografts from other skin tissue banks, Hannover Medical School has been building up its own skin tissue bank based on allogeneic skin grafts from living donors who underwent surgical treatment (i.e., body‐contouring procedures, such as abdominioplasties). This article presents procedures and protocols for the procurement and processing of allogeneic skin grafts according to national legislation and European regulations and guidelines. Beside protocols, initial microbiological data regarding the sterility of the harvested grafts are presented. The results currently form the basis for further investigations as well as clinical applications. In summary, a microbiological testing and acceptance procedure is presented that ensures adequate patient safety and skin viability.

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Challenges in the provision of skin in the UK: the use of human deceased donor skin in burn care relating to mass incidents in the UK

Cited by 3 publications

References 26 publications

The urgent need to achieve an optimal strategic stock of human allogeneic skin graft materials in case of a mass disaster in Poland

The urgent need to achieve an optimal strategic stock of human allogeneic skin graft materials in case of a mass disaster in Poland

A Survey of 1000 Respondents on the Polish Population’s Knowledge and Attitudes about Tissue/Organ Donation and Transplantation in Times of Allogeneic Tissue Shortage

Organization of Hannover Skin Bank: Sterile culture and procurement protocols for viable cryopreserved allogeneic skin grafts of living donors

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