Challenges in the local delivery of peptides and proteins for oral mucositis management

Campos, João C.; Cunha, João D.; Ferreira, Domingos; Reis, Salette; Costa, Paulo

doi:10.1016/j.ejpb.2018.04.025

Cited by 10 publications

(2 citation statements)

References 255 publications

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“…3,[21][22][23] A variety of methods have been tried for the prevention or treatment of mucositis, including ice chips, glutamine and N-acetylcysteine, benzydamine hydrochloride, benzydamine hydrochloride, luteolin, peptides, and prostaglandin E1and E2, but none has proven benefits in patients receiving prolonged infusions of HDMTX. 3,9,10,24,25 Some authors declared that Palifermin, a recombinant human keratinocyte growth factor that stimulates growth of epithelial cells, could reduce the incidence of mucositis, but no agreement has been reached on the standardized interventions till now. 3,9 When mucositis occurred, clinicians in our hospital choose to modify the dosing of leucovorin to minimize the side effects, but there is a lag behind adverse reactions, the ongoing cellular damage can cause secondary infection and result in longer stays of hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Association of MTHFR and ABCB1 polymorphisms with MTX‐induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma—A retrospective cohort study

et al. 2021

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What is known and objective: MTX pharmacology and toxicity involve several metabolizing enzymes and transporters whose functions have been suggested to be altered by genetic polymorphisms. The current study is to investigate the relationship between the genetic variation and MTX-induced adverse drug effects.Methods: A total of 80 paediatric patients (aged 1-14 years) were enrolled in this study. Toxicity was assessed according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 scoring system. Genotyping was performed by MassARRAY Assay method. Data were analysed using Spss statistical

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Section: Discussionmentioning

confidence: 99%

Association of MTHFR and ABCB1 polymorphisms with MTX‐induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma—A retrospective cohort study

et al. 2021

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“…It is recognized as one of the most noteworthy adverse events because it may result in a decrease in QOL or the rate of completion of therapy. Various clinical trials on the prevention of mucositis induced by anti-cancer therapies are ongoing [ 56 , 57 , 58 ]. For example, in patients with head and neck cancer, a randomized single (physician)-blind trial with an RJ-treated group ( n = 7) and a control group ( n = 6) was performed to evaluate the clinical utility of RJ for the prevention of oral and esophageal mucositis [ 59 ].…”

Section: Activity Of Royal Jelly Against Cancer Therapy-induced Tomentioning

confidence: 99%

Anti-Cancer and Protective Effects of Royal Jelly for Therapy-Induced Toxicities in Malignancies

Miyata

Sakai

2018

IJMS

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Royal jelly (RJ) is a glandular secretion produced by worker honeybees and is a special food for the queen honeybee. It results in a significant prolongation of the lifespan of the queen honeybee compared with the worker honeybees through anti-inflammatory, anti-oxidant and anti-microbial activities. Consequently, RJ is used as cosmetic and dietary supplement throughout the world. In addition, in vitro studies and animal experiments have demonstrated that RJ inhibits cell proliferation and stimulates apoptosis in various types of malignant cells and affects the production of various chemokines, anti-oxidants and growth factors and the expression of cancer-related molecules in patients with malignancies, especially in patients treated with anti-cancer agents. Therefore, RJ is thought to exert anti-cancer effects on tumor growth and exhibit protective functions against drug-induced toxicities. RJ has also been demonstrated to be useful for suppression of adverse events, the maintenance of the quality of life during treatment and the improvement of prognosis in animal models and patients with malignancies. To understand the mechanisms of the beneficial effects of RJ, knowledge of the changes induced at the molecular level by RJ with respect to cell survival, inflammation, oxidative stress and other cancer-related factors is essential. In addition, the effects of combination therapies of RJ and other anti-cancer agents or natural compounds are important to determine the future direction of RJ-based treatment strategies. Therefore, in this review, we have covered the following five issues: (1) the anti-cancer effects of RJ and its main component, 10-hydroxy-2-decenoic acid; (2) the protective effects of RJ against anti-cancer agent-induced toxicities; (3) the molecular mechanisms of such beneficial effects of RJ; (4) the safety and toxicity of RJ; and (5) the future directions of RJ-based treatment strategies, with a discussion on the limitations of the study of the biological activities of RJ.

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Glucose and pH Dual‐Responsive Nanogels for Efficient Protein Delivery

Song

Yang

et al. 2019

Macromolecular Bioscience

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Direct delivery of protein suffers from their in vitro and in vivo instability, immunogenicity, and a relatively short half‐life within the body. To overcome these challenges, pH and glucose dual‐responsive biodegradable nanogels comprised of dextran and poly(L‐glutamic acid)‐g‐methoxy poly‐(ethylene glycol)/phenyl boronic acid (PLG‐g‐mPEG/PBA) are designed. The cross‐linked network imparted drug‐loading efficacy of α‐amylase up to 55.6% and hyaluronidase up to 29.1%. In vitro protein release profiles reveal that the release of protein is highly dependent on the pH or glucose concentrations, that is, less amount of protein is released at pH 7.4 or healthy blood glucose level (1 mg mL−1 glucose), while quicker release of protein occurs at pH 5.5 or diabetic blood glucose level (above 3 mg mL−1 glucose). Circular dichroism spectra show that the secondary structure of released protein is maintained compared to naive protein. Overall, the nanogels have provided a simple and effective strategy to deliver protein.

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Challenges in the local delivery of peptides and proteins for oral mucositis management

Cited by 10 publications

References 255 publications

Association of MTHFR and ABCB1 polymorphisms with MTX‐induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma—A retrospective cohort study

Association of MTHFR and ABCB1 polymorphisms with MTX‐induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma—A retrospective cohort study

Anti-Cancer and Protective Effects of Royal Jelly for Therapy-Induced Toxicities in Malignancies

Glucose and pH Dual‐Responsive Nanogels for Efficient Protein Delivery

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