Challenges in the early diagnosis of dengue: A practical approach

Lakshmi, Poongodi S.; Nainar, Palaniappan

doi:10.4103/0974-5009.132833

Cited by 3 publications

(2 citation statements)

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“…Si bien sólo el 12% de los pacientes con resultados negativos para IgM manifestó haber cursado con la enfermedad anteriormente, muchas infecciones pueden pasar desapercibidas, esto podría explicar en parte la alta proporción de resultados negativos obtenidos en este estudio. En cuanto a las infecciones inaparentes, estudios poblacionales sugieren que las infecciones asintomáticas son el principal resultado de la exposición al virus del dengue (24). Este hecho refuerza la idea de un enfoque global para el diagnóstico definitivo apoyándose en todas las herramientas posibles.…”

Section: Discussionunclassified

Clinical, hematological and serological profile in suspected dengue patients at IICS-UNA, 2009-2013

Rojas

Aria

Guillén

et al. 2016

Mem. Inst. Investig. Cienc. Salud

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Section: Discussionunclassified

Clinical, hematological and serological profile in suspected dengue patients at IICS-UNA, 2009-2013

Rojas

Aria

Guillén

et al. 2016

Mem. Inst. Investig. Cienc. Salud

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“…However, it exhibits extensive cross reactivity in serological tests because they are closely related antigenically. [2,4] DHF occurs mostly in persons with heterotypic secondary infection. It has been well recognized that the inflammatory response and deregulated cytokine production play a crucial role in DHF/ DSS.…”

Section: Introductionmentioning

confidence: 99%

Obstacles in Dengue Diagnosis and Severity Prediction

Chidambaram,

Kumarasamy

2023

Apollo Medicine

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Background: Dengue emerges as a perennial public health menace. Identification of patients at risk of developing dengue hemorrhagic fever (DHF)/dengue shock syndrome is still a huge challenge. Objective: In this background, this study was done to predict the severity of dengue by measuring the interleukin (IL) 6 and IL8 by enzyme-linked immunosorbent assay (ELISA). Materials and Methods: A total of 88 samples were collected from patients with clinical signs suggestive of dengue were tested for NS1 and immunoglobulin (Ig) M (NIV Pune), and proinflammatory markers IL-6 and IL-8 (Diaclone SAS Pvt Ltd., France) by ELISA. Results: All the 88 patients were positive for dengue IgM. Dengue NS1 was positive in 36 patients. IL-6 and IL-8 were raised in 56 cases and 46 cases, respectively. Out of 32 severe dengue cases, 24 had raised IL-6 and IL-8. Conclusion: The dynamic nature of dengue requires close monitoring and frequent clinical and laboratory evaluations. Early prediction requires prompt testing of all the markers (IgM, IgG, and NS1) irrespective of the day of illness. Although cytokine estimation aids in assessing the severity, other cost-effective alternatives (hematocrit and platelet count) are copacetic.

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An economic evaluation of implementing a decentralized dengue screening intervention under the National Vector Borne Disease Control Programme in Tamil Nadu, South India

Muniyandi

Nagarajan

Ravi

et al. 2021

International Health

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Background Lack of effective early screening is a major obstacle for reducing the fatality rate and disease burden of dengue. In light of this, the government of Tamil Nadu has adopted a decentralized dengue screening strategy at the primary healthcare (PHC) facilities using blood platelet count. Our objective was to determine the cost-effectiveness of a decentralized screening strategy for dengue at PHC facilities compared with the current strategy at the tertiary health facility (THC) level. Methods Decision tree analysis followed a hypothetical cohort of 1000 suspected dengue cases entering the model. The cost-effectiveness analysis was performed at a 3% discount rate for the proposed and current strategy. The outcomes are expressed in incremental cost-effectiveness ratios (ICERs) per quality-adjusted life years gained. One-way sensitivity analysis and probabilistic sensitivity analysis were done to check the uncertainty in the outcome. Results The proposed strategy was found to be cost-saving and ICER was estimated to be −41 197. PSA showed that the proposed strategy had a 0.84 probability of being an economically dominant strategy. Conclusions The proposed strategy is cost-saving, however, it is recommended to consider optimal population coverage, costs to economic human resources and collateral benefits of equipment.

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Challenges in the early diagnosis of dengue: A practical approach

Cited by 3 publications

References 0 publications

Clinical, hematological and serological profile in suspected dengue patients at IICS-UNA, 2009-2013

Clinical, hematological and serological profile in suspected dengue patients at IICS-UNA, 2009-2013

Obstacles in Dengue Diagnosis and Severity Prediction

An economic evaluation of implementing a decentralized dengue screening intervention under the National Vector Borne Disease Control Programme in Tamil Nadu, South India

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