Challenges in ovine footrot control

Allworth, Maxwell

doi:10.1016/j.smallrumres.2013.12.007

Cited by 19 publications

(22 citation statements)

References 19 publications

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“…The grading of virulence of strains of D. nodosus is poorly defined . Stewart et al used bodyweight changes and TFS in challenged sheep to distinguish virulent, intermediate and benign strains of D. nodosus .…”

Section: Discussionmentioning

confidence: 99%

Artificial infection of sheep with multiple strains ofDichelobacter nodosusto induce footrot

Allworth

Egerton

2017

Aust Veterinary J

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Section: Discussionmentioning

confidence: 99%

Artificial infection of sheep with multiple strains ofDichelobacter nodosusto induce footrot

Allworth

Egerton

2017

Aust Veterinary J

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“…). In its final stage, footrot may lead to under‐running of the sole and separation of the horn from the underlying hoof matrix (Allworth ). The disease phenotype can vary greatly from mild lameness with no other clinical signs to extreme lameness or locomotion on the carpal joints accompanied by secondary signs such as reduced wool growth/quality, poor fertility and poor growth rates (Zingg et al .…”

Section: Statistics For the Three Lead Single Nucleotide Polymorphismmentioning

confidence: 99%

A genome‐wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep

et al. 2017

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Footrot is one of the most important causes of lameness in global sheep populations and is characterized by a bacterial infection of the interdigital skin. As a multifactorial disease, its clinical representation depends not only on pathogen factors and environmental components but also on the individual resistance/susceptibility of the host. A genetic component has been shown in previous studies; however, so far no causative genetic variant influencing the risk of developing footrot has been identified. In this study, we genotyped 373 Swiss White Alpine sheep, using the ovine high-density 600k SNP chip, in order to run a DNA-based comparison of individuals with known clinical footrot status. We performed a case-control genome-wide association study, which revealed a genome-wide significant association for SNP rs418747104 on ovine chromosome 2 at 81.2 Mb. The three best associated SNP markers were located at the MPDZ gene, which codes for the multiple PDZ domain crumbs cell polarity complex component protein, also known as multi-PDZ domain protein 1 (MUPP1). This protein is possibly involved in maintaining the barrier function and integrity of tight junctions. Therefore, we speculate that individuals carrying MPDZ variants may differ in their footrot resistance/susceptibility due to modified horn and interdigital skin integrity. In conclusion, our study reveals that MPDZ might represent a functional candidate gene, and further research is needed to explore its role in footrot affected sheep.

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“…Dichelobacter nodosus is the essential organism for causing footrot, while interdigital dermatitis is caused by Fusobacterium necrophorum, which is also thought to play an important role in the pathogenesis of footrot (Egerton et al, 1989). Pathogenesis, clinical appearance, differential diagnosis and control measures of interdigital dermatitis and footrot have been recently reviewed (Winter, 2008;Raadsma and Egerton, 2013;Allworth, 2014). While methods of treatment and control of these diseases are readily available, the need to make a rapid and simple diagnosis remains a key feature in treating and controlling lameness in sheep flocks.…”

Section: Introductionmentioning

confidence: 99%

The use of digital infrared thermography and measurement of oxidative stress biomarkers as tools to diagnose foot lesions in sheep

Talukder

Gabai

Celi

2015

Small Ruminant Research

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Challenges in ovine footrot control

Cited by 19 publications

References 19 publications

Artificial infection of sheep with multiple strains ofDichelobacter nodosusto induce footrot

Artificial infection of sheep with multiple strains ofDichelobacter nodosusto induce footrot

A genome‐wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep

The use of digital infrared thermography and measurement of oxidative stress biomarkers as tools to diagnose foot lesions in sheep

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