Challenges in diagnosis of polycystic ovary syndrome in adolescence

Asanidze, Elene; Kristesashvili, J.; Parunashvili, Nino; Karelishvili, Natalia; Etsadashvili, Nana

doi:10.1080/09513590.2021.1943344

Cited by 5 publications

(13 citation statements)

References 21 publications

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“…The results showed that the levels of total testosterone, free testosterone, dehydroepiandrosterone, LH, LH/FSH, blood glucose, and insulin in the PCOS group were significantly higher than those in the control group. Increased LH secretion leads to increased androgen production by theca cells, and increased conversion of androgens in theca cells leads to increased production of androstenedione, which is also an important cause of hirsutism and acne in PCOS patients [ 1 , 11 , 23 ]. It is also well-known that PCOS patients will develop insulin resistance, which is not difficult to explain the manifestations of increased blood glucose in patients [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of childbearing age and mostly occurs in women aged 20–40 in childbearing periods. Its prevalence is between 5% and 10% [ 1 ]. The causes of PCOS include genetic factors, environmental factors, or obesity.…”

Section: Introductionmentioning

confidence: 99%

“…It also involves abnormal secretion of gonadotropins, such as elevated LH levels, and a subsequent increase in the LH to follicle stimulating hormone (FSH) ratio in addition to elevated androgen levels [ 1 ] in endocrine and metabolic aspects, which are thought to be common features of PCOS [ 8 , 9 ]. Elevated levels of anti-Samuel's canal hormone (AMH) are another typical feature [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship between Ovarian Ultrasound Parameters and Endocrine and Metabolic Indicators in Patients with Ovarian Syndrome

Sheng

Zhang²,

Jiang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study is to investigate the relationship between the levels of endocrine and metabolic indicators and ovarian ultrasonography indicators in patients with ovarian syndrome (PCOS). Methods. Three hundred and forty patients with PCOS from January 2017 to February 2022 were selected as the observation group, and 340 healthy women of the same age were selected as the control group. A retrospective analysis was performed to observe the levels of endocrine and metabolic indicators and ovarian ultrasound examination indicators in the two groups. Results. The levels of testosterone, dehydroepiandrosterone (DHEA-S), luteinizing hormone (LH), LH/FSH, blood glucose, and insulin were higher in the observation group than those in the control group. The levels of low-density lipoprotein (LDL) and free insulin-like growth factor (IGF-I) were higher in the observation group than those in the control group. However, the level of high-density lipoprotein (HDL) was lower in the observation group than that in the control group. The ovarian interstitial area, total ovarian area, ovarian volume, number of follicles, uterine artery pulsatility index (PI), and resistance index (RI) were higher in the observation group than those in the control group. Pearson correlation analysis concluded that estrone (E1) levels in PCOS patients were correlated with ovarian interstitial area, total ovarian area, and ovarian volume. In addition, E1 levels correlated with LH levels, LH/FSH, testosterone, DHEA-S, and progesterone at P < 0.05 . Compared with different treatment methods, the total testosterone, LH, and LH/FSH levels in the two groups were decreased compared with those before treatment, and the degree of decrease in the combined treatment group was more significant than that in the treatment alone group. Conclusion. The levels of endocrine metabolism and ovarian ultrasound in PCOS patients are abnormal and there is a close relationship between the levels of endocrine metabolism and ovarian ultrasound. Attention should be paid to the monitoring and regulation of endocrine metabolism and ovarian ultrasound. Integrated traditional Chinese and western medicine can greatly improve the hormone levels in PCOS patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Relationship between Ovarian Ultrasound Parameters and Endocrine and Metabolic Indicators in Patients with Ovarian Syndrome

Sheng

Zhang²,

Jiang

2022

Evidence-Based Complementary and Alternative Medicine

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“…A cross-sectional study of 154 adolescents two years post-menarche in Canada including 60 with PCOS according to Rotterdam criteria, 48 who were classified as at risk of PCOS by authors but fulfill NIH PCOS criteria, and 46 healthy controls showed mean mFG of 17.1, 15.9, and 5.7, respectively. The presence of hirsutism and acne was similar among the adolescents with PCOS diagnosed using Rotterdam or NIH criteria [ 68 ]. Lower mean mFG scores (6–8.5) were reported in cohorts of adolescents with PCOS in the USA including Hispanics and black adolescents [ 69 , 70 ].…”

Section: Main Criteria To Diagnose Pcos During Adolescencementioning

confidence: 99%

“…Lower mean mFG scores (6–8.5) were reported in cohorts of adolescents with PCOS in the USA including Hispanics and black adolescents [ 69 , 70 ]. Hirsutism defined as mFG score higher than 6 and higher than 8 was reported in 60–70% and 50% of adolescents with PCOS respectively [ 8 , 68 , 70 ]. Higher hirsutism scores are related to higher testosterone levels according to population and cross-sectional studies of adolescents [ 59 , 60 , 69 , 71 , 72 ].…”

Section: Main Criteria To Diagnose Pcos During Adolescencementioning

confidence: 99%

Criteria for Diagnosis of Polycystic Ovary Syndrome during Adolescence: Literature Review

2022

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine conditions in women. PCOS may be more challenging to diagnose during adolescence due to an overlap with the physiological events of puberty, which are part of the diagnostic criteria in adult women. This review focuses on the evidence available in relation to PCOS diagnostic criteria for adolescents. Adolescent PCOS should be diagnosed using two main criteria irregular -menstrual cycles (relative to number of years post-menarche) and hyperandrogenism (clinical and/or biochemical); after excluding other conditions that mimic PCOS. Accurate definitions of the two main criteria will decrease challenges/controversies with the diagnosis and provide timely diagnosis during adolescence to establish early management. Despite the attempts to create accurate diagnostic criteria and definitions, this review highlights the limited research in this area, especially in the follow up of adolescents presenting with one diagnostic feature that are called “at risk of PCOS”. Studies in adolescents continue to use the Rotterdam diagnostic criteria that uses pelvic ultrasound. This is inappropriate, because previous and emerging data that show many healthy adolescents have polycystic ovarian morphology in the early years post-menarche. In the future, anti-Müllerian hormone levels might help support PCOS diagnosis if adolescents meet two main criteria.

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Diagnosis values of three-dimensional power Doppler ultrasonography in polycystic ovary syndrome and its relationship with serum sex hormone levels

2023

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Challenges in diagnosis of polycystic ovary syndrome in adolescence

Cited by 5 publications

References 21 publications

The Relationship between Ovarian Ultrasound Parameters and Endocrine and Metabolic Indicators in Patients with Ovarian Syndrome

The Relationship between Ovarian Ultrasound Parameters and Endocrine and Metabolic Indicators in Patients with Ovarian Syndrome

Criteria for Diagnosis of Polycystic Ovary Syndrome during Adolescence: Literature Review

Diagnosis values of three-dimensional power Doppler ultrasonography in polycystic ovary syndrome and its relationship with serum sex hormone levels

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