Challenges in developing of chitosan – Based polyelectrolyte complexes as a platform for mucosal and skin drug delivery

Potaś, Joanna; Szymańska, Emilia; Winnicka, Katarzyna

doi:10.1016/j.eurpolymj.2020.110020

Cited by 51 publications

(28 citation statements)

References 130 publications

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“…In Figure 4 b–e, it can be clearly seen that the difference in CNC contents resulted in different morphologies. The reason is probably that the macromolecular framework of CNCs can dynamically respond to external conditions to form various aggregate structures and form a variety of morphologies with counter ions (the monomer of TAPP) through electrostatic interactions [ 40 , 41 , 42 ]. Adding different amounts of CNCs in the same volume of aqueous solution led to different aggregate structures and then interacts with TAPP to form different forms.…”

Section: Resultsmentioning

confidence: 99%

Cellulose Nanocrystals as Template for Improving the Crystallinity of Two-Dimensional Covalent Organic Framework Films

Liang

et al. 2021

Polymers

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Despite the rapid development of two-dimensional covalent organic frameworks (2D COFs) in recent years, it remains a great challenge to synthesize highly crystalline COF materials. Here, a CNC-assisted approach was adopted to synthesize high crystallinity COF materials. A series of 2D COF films were synthesized at the air–water interface by using cellulose nanocrystals (CNCs) as the template. The occurrence of Schiff reactions based on the imine bond was demonstrated by Raman spectroscopy and Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) exhibited the appearances of 2D COF films were flower-like. When CNCs were added to a certain extent, the size of a single petal in the flowers gradually increased with the amount of CNCs. The film with large petals was characterized by Ultraviolet–Visible diffuse reflectance spectroscopy (UV–Vis DRS), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), and selected area electron diffraction (SAED). In UV–Vis DRS curves, the S-band of COF-366 film was red-shifted by 24 nm compared with that of 5,10,15,20-tetrakis(4-aminophenyl)-21H,23H-porphyrin (TAPP), confirming the existence of extended conjugation in COF-366 film. XPS was used to identify the surface composition of the sample. The N1s signal of the film indicated that each TAPP formed four imine bonds with 2,5-dihydroxyterephthalaldehyde (DHTA) in COF-366 film. TEM images showed that CNCs had an influence on the crystal size. It was observed from SAED that the crystallinity of the film with CNCs was higher than the film without CNCs. This work provided a new template for improving the crystallinity of 2D COF films.

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Section: Resultsmentioning

confidence: 99%

Cellulose Nanocrystals as Template for Improving the Crystallinity of Two-Dimensional Covalent Organic Framework Films

Liang

et al. 2021

Polymers

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“…This may, in turn, cause difficulties in providing the structural homogeneity that may aid their deployment in living systems. A number of technological factors, including pH alterations, charge density, or polymer concentration, may determine or modulate the physicochemical and biological properties of the PECs formed [ 184 ]. Upon ionization, polyelectrolytes become pH-responsive polymers that can undergo various changes in their physical structure, including extension of their coiled chains as a result of electrostatic repulsion between positive charges generated protonation at low pH [ 185 ].…”

Section: Polymer-based Smart Nanocarriersmentioning

confidence: 99%

Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters

Nikkhah

Thompson

2021

Pharmaceutics

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Nanomedicine employs molecular materials for prevention and treatment of disease. Recently, smart nanoparticle (NP)-based drug delivery systems were developed for the advanced transport of drug molecules. Rationally engineered organic and inorganic NP platforms hold the promise of improving drug targeting, solubility, prolonged circulation, and tissue penetration. However, despite great progress in the synthesis of NP building blocks, more interdisciplinary research is needed to understand their self-assembly and optimize their performance as smart nanocarriers. Multi-scale modeling and simulations provide a valuable ally to experiment by mapping the potential energy landscape of self-assembly, translocation, and delivery of smart drug-loaded NPs. Here, we highlight key recent advances to illustrate the concepts, methods, and applications of smart polymer-based NP drug delivery. We summarize the key design principles emerging for advanced multifunctional polymer topologies, illustrating how the unusual architecture and chemistry of dendritic polymers, self-assembling polyelectrolytes and cyclic polymers can provide exceptional drug delivery platforms. We provide a roadmap outlining the opportunities and challenges for the effective use of predictive multiscale molecular modeling techniques to accelerate the development of smart polymer-based drug delivery systems.

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“…25 PECs have been used to prepare systems for drug delivery. 26 Structurally, these are neutral polymer-polymer complexes consisting of macromolecules with opposite charges causing the electrostatic interactions to bind macromolecules together. In PEC formation, ion dipole interactions, hydrogen bonding and hydrophobic interactions play a major role.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antitumor Efficacy of Chitosan-Tamarind Gum Polysaccharide Polyelectrolyte Complex Stabilized Nanoparticles of Simvastatin

Malviya

Raj

Fuloria

et al. 2021

IJN

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The present study was intended to fabricate chitosan (Ch)-tamarind gum polysaccharide (TGP) polyelectrolyte complex stabilized cubic nanoparticles of simvastatin and evaluate their potential against human breast cancer cell lines. Materials and Methods: The antisolvent precipitation method was used for formulation of nanoparticles. Factorial design (3 2 ) was utilized as a tool to analyze the effect of Ch and TGP concentration on particle size and entrapment efficiency of nanoparticles. Results: Formulated nanoparticles showed high entrapment efficiency (67.19±0.42-83.36 ±0.23%) and small size (53.3-383.1 nm). The present investigation involved utilization of two biological membranes (egg and tomato) as biological barriers for drug release. The study revealed that drug release from tomato membranes was retarded (as compared to egg membranes) but the release pattern matched that of egg membranes. All formulations followed the Baker-Lansdale model of drug release irrespective of the two different biological barriers. Stability studies were carried out for 45 days and exhibited less variation in particle size as well as a reduction in entrapment efficiency. Simvastatin loaded PEC stabilized nanoparticles exhibited better control on growth of human breast cancer cell lines than simple simvastatin. An unusual anticancer effect of simvastatin nanoparticles is also supported by several other research studies. Conclusion:The present study involves first-time synthesis of Ch-TGP polyelectrolyte complex stabilized nanoparticles of simvastatin against MCF-7 cells. It recommends that, in future, theoretical modeling and IVIVC should be carried out for perfect designing of delivery systems.

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Challenges in developing of chitosan – Based polyelectrolyte complexes as a platform for mucosal and skin drug delivery

Cited by 51 publications

References 130 publications

Cellulose Nanocrystals as Template for Improving the Crystallinity of Two-Dimensional Covalent Organic Framework Films

Cellulose Nanocrystals as Template for Improving the Crystallinity of Two-Dimensional Covalent Organic Framework Films

Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters

Evaluation of Antitumor Efficacy of Chitosan-Tamarind Gum Polysaccharide Polyelectrolyte Complex Stabilized Nanoparticles of Simvastatin

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