Challenges in creating diabetes mellitus animal model for physiological research

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from abnormalities in insulin secretion, insulin action, or both. Diabetes mellitus is one of the global health problems, and its prevalence continues to increase from year to year. Diabetes mellitus has several types, among which the most commonly encountered are type 1 diabetes and type 2 diabetes. Studies related to diabetes mellitus need to be conducted to understand preventive and curative measures that can be taken to address this disease. There are various methods that can be used to study diabetes mellitus, one of which is using experimental animals. This article briefly explains various methods that can be used in inducing diabetes in experimental animals, along with the advantages and disadvantages of these methods.