Challenges in bioremediation: from lab to land

Nandy, Sampurna; Andraskar, Jayanta; Lanjewar, Krutika; Kapley, Atya

doi:10.1016/b978-0-12-820524-2.00023-7

Cited by 6 publications

(2 citation statements)

References 81 publications

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“…Similar issues in biotechnology are numerous. Scaling bioremediation beyond the lab remains challenging due to the complexity of microbial communities in natural environments [108]. Phage therapy is often less effective than expected due to the presence of biofilms and the interaction with the human immune system [118].…”

Section: Novelty Before Fitnessmentioning

confidence: 99%

Open-endedness in synthetic biology: a route to continual innovation for biological design

Stock¹,

Gorochowski²

2023

Preprint

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Design in synthetic biology is typically goal-oriented: aiming to repurpose and optimize existing biological functions for new contexts, augmenting biology with new-to-nature capabilities, or creating life-like systems from scratch. While the field has seen many advances over the past two decades, bottlenecks in the complexity of the systems built are emerging and designs that function in the lab often fail when used in real-world contexts. Here, we propose an open-ended approach to biological design that aims to continuously generate innovative solutions capable of overcoming such hurdles. The fundamental principle we put forward is that the novelty of designed biology, be it a protein, genetic construct or organism, is at least as important as how well it fulfils its goal. Designing with novelty in mind, rather than a sole focus on optimization towards a single ``best'' design, may allow us to move beyond the diminishing returns we see in performance for most engineered biology to date. Research from the artificial life and evolutionary computing communities has demonstrated that embracing novelty can allow for the automatic generation of innovative and surprising solutions to challenging problems that move us beyond local optima. Synthetic biology now offers the ideal playground to test these ideas in living systems and explore more creative approaches to biological design.

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Section: Novelty Before Fitnessmentioning

confidence: 99%

Open-endedness in synthetic biology: a route to continual innovation for biological design

Stock¹,

Gorochowski²

2023

Preprint

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“…Long-term exposure generates modifications in species richness and diversity, with metal-resistant strains becoming dominant, albeit fewer in number [ 36 ]. Non-native microbial communities are in competition with the native microbiota and face difficulties in surviving in a polluted environment [ 37 ], whereas native strains develop tolerance over time through several extracellular and intracellular mechanisms, thus being more efficient in bioremediation [ 38 , 39 , 40 ]. Pollution-induced community tolerance (PICT) was proposed for the first time in 1988 by Blanck et al [ 41 ], which suggests that microbial communities exposed to xenobiotic compounds for a sufficient period of time could develop selective resistance as well as suffer modifications in species composition.…”

Section: Introductionmentioning

confidence: 99%

Microbial Removal of Heavy Metals from Contaminated Environments Using Metal-Resistant Indigenous Strains

Firincă,

Zamfir,

Constantin

et al. 2023

JoX

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Contamination of soil with heavy metals has become a matter of global importance due to its impact on agriculture, environmental integrity, and therefore human health and safety. Several microbial strains isolated from soil contaminated by long-term chemical and petrochemical activities were found to manifest various levels of tolerance to Cr, Pb, and Zn, out of which Bacillus marisflavi and Trichoderma longibrachiatum exhibited above-moderate tolerance. The concentrations of target heavy metals before and after bioremediation were determined using electrochemical screen-printed electrodes (SPE) modified with different nanomaterials. The morpho-structural SEM/EDX analyses confirmed the presence of metal ions on the surface of the cell, with metal uptake being mediated by biosorption with hydroxyl, carboxyl, and amino groups as per FTIR observations. T. longibrachiatum was observed to pose a higher bioremediation potential compared to B. marisflavi, removing 87% of Cr and 67% of Zn, respectively. Conversely, B. marisflavi removed 86% of Pb from the solution, compared to 48% by T. longibrachiatum. Therefore, the fungal strain T. longibrachiatum could represent a viable option for Cr and Zn bioremediation strategies, whereas the bacterial strain B. marisflavi may be used in Pb bioremediation applications.

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Comparison of Native Bacterial and Fungal Bioaugmentation in the Removal of Petroleum from Soil in the Presence of Sorghum

Koohkan¹,

Mortazavi²,

Golchin

et al. 2023

Water Air Soil Pollut

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Challenges in bioremediation: from lab to land

Cited by 6 publications

References 81 publications

Open-endedness in synthetic biology: a route to continual innovation for biological design

Open-endedness in synthetic biology: a route to continual innovation for biological design

Microbial Removal of Heavy Metals from Contaminated Environments Using Metal-Resistant Indigenous Strains

Comparison of Native Bacterial and Fungal Bioaugmentation in the Removal of Petroleum from Soil in the Presence of Sorghum

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