Challenges in Addressing Depression in HIV Research: Assessment, Cultural Context, and Methods

Simoni, Jane M.; Safren, Steven A.; Manhart, Lisa E.; Lyda, Karen; Grossman, Cynthia; Rao, Deepa; Mimiaga, Matthew J.; Wong, Frank Y.; Catz, Sheryl L.; Blank, Michael B.; DiClemente, Ralph J.; Wilson, Ira B.

doi:10.1007/s10461-010-9836-3

Cited by 102 publications

(129 citation statements)

References 122 publications

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“…44 Depression screening should be offered universally to newly diagnosed MSM and depression treatment should be provided, when applicable. Integrating treatment for depression into HIV care, including cognitive behavioral therapy (CBT) and pharmacological approaches, has been successful among patients living with HIV 45 and, in turn, can increase HIV treatment adherence. 46 So that both partners in a sexual relationship can make informed decisions about risk reduction, 47 efforts to increase disclosure should specifically address disclosure self-efficacy for the different types of partners and situations in which one may need to disclose.…”

Section: Discussionmentioning

confidence: 99%

Depression and HIV Serostatus Disclosure to Sexual Partners Among Newly HIV-Diagnosed Men Who Have Sex with Men

Abler

Sikkema

Watt

et al. 2015

AIDS Patient Care and STDs

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HIV disclosure to sexual partners facilitates joint decision-making and risk reduction strategies for safer sex behaviors, but disclosure may be impacted by depression symptoms. Disclosure is also associated with disclosure self-efficacy, which in turn may also be influenced by depressive symptoms. This study examined the relationship between depression and HIV disclosure to partners following diagnosis among men who have sex with men (MSM), mediated by disclosure self-efficacy. Newly HIV-diagnosed MSM (n = 92) who reported sexual activity after diagnosis completed an assessment soon after diagnosis which measured depressive symptoms, and another assessment within 3 months of diagnosis that measured disclosure self-efficacy and disclosure. Over one-third of the sample reported elevated depressive symptoms soon after diagnosis and equal proportions (one-third each) disclosed to none, some, or all partners in the 3 months after diagnosis. Depressive symptoms were negatively associated with disclosure self-efficacy and disclosure to partners, while disclosure self-efficacy was positively associated with disclosure. Disclosure self-efficacy partially mediated the relationship between depression and disclosure, accounting for 33% of the total effect. These findings highlight the importance of addressing depression that follows diagnosis to enhance subsequent disclosure to sexual partners.

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Section: Discussionmentioning

confidence: 99%

Depression and HIV Serostatus Disclosure to Sexual Partners Among Newly HIV-Diagnosed Men Who Have Sex with Men

Abler

Sikkema

Watt

et al. 2015

AIDS Patient Care and STDs

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“…Depression is one of the most common comorbidities of HIV infection (Simoni et al, 2011). Previous studies have shown that depression not only negatively impacts the QoL of PLWHA (Briongos Figuero, Bachiller Luque, Palacios Martin, Gonzalez Sagrado, & Eiros Bouza, 2011;Simoni et al, 2011) but also relates to rapid disease progression (Gore-Felton et al, 2006), as evidenced by a decline in CD4+ cell count, increased viral load, higher frequencies of health care visits and hospitalizations, and reduced survival rates (Mavandadi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that depression not only negatively impacts the QoL of PLWHA (Briongos Figuero, Bachiller Luque, Palacios Martin, Gonzalez Sagrado, & Eiros Bouza, 2011;Simoni et al, 2011) but also relates to rapid disease progression (Gore-Felton et al, 2006), as evidenced by a decline in CD4+ cell count, increased viral load, higher frequencies of health care visits and hospitalizations, and reduced survival rates (Mavandadi et al, 2009). Depression is associated with worsening disease management because depressive symptoms may have a negative effect on medication adherence and compliance with treatment regimens (Mavandadi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Mediating effects of social support on depression and quality of life among patients with HIV infection in Taiwan

et al. 2014

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Few empirical studies have evaluated the mediating effects of quality of life (QoL) among people living with HIV/AIDS (PLWHA). The purposes of this study were to identify the predictors of QoL and to test the mediating effects of social support on depression and QoL among patients enrolled in an HIV case-management program in Taiwan. A cross-sectional, descriptive correlation design collected data from 108 HIV-infected individuals. Individuals were assessed using the Beck Depression Inventory II, the short version of the World Health Organization Quality of Life Assessment (WHOQOL-BREF), and the Multidimensional Scale of Perceived Social Support between September 2007 and April 2010. After adjusting for sociodemographic characteristics (including age, gender, and mode of transmission) and clinical information (including CD4 count and time since diagnosis with HIV), the study findings showed that QoL was significantly and positively correlated with both social support and the initiation of highly active antiretroviral therapy (HAART), and was negatively correlated with depression and time since diagnosis with HIV. The strongest predictors for QoL were depression followed by the initiation of HAART and social support, with an R(2) of 0.40. Social support partially mediated the relationship between depression and QoL. Health professionals should enhance HIV-infected individuals' social support to alleviate the level of depression and further increase the QoL among PLWHA.

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“…It has been linked with poor medication adherence among individuals infected with HIV, 4 and even depressive symptoms that do not meet diagnostic criteria for major depressive disorder can disrupt self-care behaviors such as poor adherence to HIV treatment regimens. 5 Adherence to combined antiretroviral therapy (cART) regimens is important in managing HIV infection and improving health by lowering viral load, improving CD4 T cell counts, and decreasing susceptibility to opportunistic diseases. 6,7 However, cART adherence is only one part of a larger picture of health maintenance in HIV/AIDS.…”

mentioning

confidence: 99%

The Role of Depression in Retention in Care for Persons Living with HIV

Zuñiga

Yoo‐Jeong

Dai

et al. 2016

AIDS Patient Care and STDs

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Individuals infected with HIV experience high rates of depression when compared to their sero-negative counterparts. Although symptoms of depression have been consistently linked to poor medication adherence among persons living with HIV/AIDS, their relation to retention in care are less well-known. The purpose of this study was to examine whether clusters of depressive symptoms influence retention in care and if so, whether these clusters had different relations to retention in care. This is a secondary data analysis of a larger study that investigated the role of health literacy, cognitive impairment, and social determinants on retention in HIV care. Individuals with HIV were recruited from South Florida from August 2009 to May 2011. A total of 210 participants were included in the current analyses. A measure of visit constancy was calculated to represent the number of 4-month intervals with at least one kept visit. Individual items on the Center for Epidemiological Studies Depression Scale short form (CES-D10) and factor analysis of the CES-D10 were independent variables. Overall, there was a high prevalence of depressive symptoms in the study participants. Furthermore, factor analysis showed that certain clusters of depressive symptoms were significantly associated with visit constancy. Specifically, negative mood/somatic symptoms were associated with a greater odds of missing a visit in any of the observed 4-month time periods than positive mood factor. Those patients reporting somatic symptoms and negative mood may need additional intervention and support to be effectively retained in care and successfully follow through with appointments and care.

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Challenges in Addressing Depression in HIV Research: Assessment, Cultural Context, and Methods

Cited by 102 publications

References 122 publications

Depression and HIV Serostatus Disclosure to Sexual Partners Among Newly HIV-Diagnosed Men Who Have Sex with Men

Depression and HIV Serostatus Disclosure to Sexual Partners Among Newly HIV-Diagnosed Men Who Have Sex with Men

Mediating effects of social support on depression and quality of life among patients with HIV infection in Taiwan

The Role of Depression in Retention in Care for Persons Living with HIV

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