Challenges for the Newborn Following Influenza Virus Infection and Prospects for an Effective Vaccine

Alexander-Miller, Martha A.

doi:10.3389/fimmu.2020.568651

Cited by 12 publications

(8 citation statements)

References 134 publications

(154 reference statements)

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“…Evidence continues to accumulate to support the overall safety, as well as efficacy and effectiveness, of pregnancy flu immunisation (Naleway et al, 2014;Regan & Munoz, 2021). This is important because maternal infection over the perinatal period can lead to severe neonatal illness (Alexander-Miller, 2020) and stillbirth (Wang et al, 2021). In 2009 women in Australia and Aotearoa NZ were seven times more likely to be admitted to Intensive Care with H1N1 influenza if they were pregnant or postpartum, than were other women of childbearing age (The ANZIC Influenza Investigators and Australasian Maternity Outcomes Surveillance System, 2010).…”

Section: Aotearoa New Zealand Research Backgroundmentioning

confidence: 99%

Women's knowledge, attitudes and access to vaccines in pregnancy: A South Auckland study

Priday¹,

Clemons²,

Krishnan³

et al. 2023

nzcomjnl

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Background: In Aotearoa New Zealand pertussis and influenza vaccinations are available free-of-charge during pregnancy, although uptake varies between District Health Board areas. Aims: This study was designed to assess the knowledge of, attitudes towards, and infrastructural access to, these vaccines for birthing people in an area of Auckland (Counties Manukau) where uptake has been low. Methods: A mixed methods research design was used involving interviews (n = 7), two focus groups (n = 9) and a paper-based survey (n = 121). Interviews and focus groups were semi-structured and analysed using thematic analysis. The survey comprised of a 20-item Likert scale. Findings: Participants displayed support for maternal vaccinations. Concerns remain regarding potential adverse effects. Awareness of the existence of vaccines in pregnancy is not universal, and 36% of survey participants were unaware that the vaccines are free-of-charge. Appreciation was expressed for trusted healthcare relationships within which people feel supported to make decisions about maternal vaccination, and for immunisation services that are easily accessible. Conclusion: The research contributes to growing evidence on the significance of health professionals providing information about immunisation in pregnancy. Also highlighted is the importance of: culturally safe knowledge sharing; information being tailored to meet individual needs; and continuity of health and maternity care to facilitate that.

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Section: Aotearoa New Zealand Research Backgroundmentioning

confidence: 99%

Women's knowledge, attitudes and access to vaccines in pregnancy: A South Auckland study

Priday¹,

Clemons²,

Krishnan³

et al. 2023

nzcomjnl

View full text Add to dashboard Cite

show abstract

“…Newborns are particularly at increased risk of severe disease following influenza infection since they may be unable to mount an effective immune response to clear infection. However, a more in-depth understanding of protective responses generated during natural influenza infection can guide development of vaccines which illicit broader responses with limited reactogenicity in these vulnerable populations ( 237 ).…”

Section: Influenzamentioning

confidence: 99%

Precision Vaccine Development: Cues From Natural Immunity

et al. 2022

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Traditional vaccine development against infectious diseases has been guided by the overarching aim to generate efficacious vaccines normally indicated by an antibody and/or cellular response that correlates with protection. However, this approach has been shown to be only a partially effective measure, since vaccine- and pathogen-specific immunity may not perfectly overlap. Thus, some vaccine development strategies, normally focused on targeted generation of both antigen specific antibody and T cell responses, resulting in a long-lived heterogenous and stable pool of memory lymphocytes, may benefit from better mimicking the immune response of a natural infection. However, challenges to achieving this goal remain unattended, due to gaps in our understanding of human immunity and full elucidation of infectious pathogenesis. In this review, we describe recent advances in the development of effective vaccines, focusing on how understanding the differences in the immunizing and non-immunizing immune responses to natural infections and corresponding shifts in immune ontogeny are crucial to inform the next generation of infectious disease vaccines.

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“…Infants who contract influenza are known to have a higher risk for severe illness than adults due to their immature immune system and smaller airway [ 3 ]. Infants combating coinfection may be at a risk for poorer outcomes than those with COVID-19 alone.…”

Section: Introductionmentioning

confidence: 99%

Apnea in a Two-Week-Old Infant Infected with SARS-CoV-2 and Influenza B

Maddali

Cervellione

Lew

2022

Case Reports in Pediatrics

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Paucity of data exists on presenting symptoms and outcomes in infants with COVID-19. Reports of coinfection with COVID-19 and influenza B are sparse in the literature. Coinfection was uncovered during evaluation of neonatal apnea. Apnea has been reported in infants with SARS-CoV-2 infection, though it is rare. We describe a 2-week-old healthy term infant presenting with apnea and coinfection. The infant had a mild clinical course and complete recovery.

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Challenges for the Newborn Following Influenza Virus Infection and Prospects for an Effective Vaccine

Cited by 12 publications

References 134 publications

Women's knowledge, attitudes and access to vaccines in pregnancy: A South Auckland study

Women's knowledge, attitudes and access to vaccines in pregnancy: A South Auckland study

Precision Vaccine Development: Cues From Natural Immunity

Apnea in a Two-Week-Old Infant Infected with SARS-CoV-2 and Influenza B

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