Challenges and techniques for presurgical brain mapping with functional MRI

Silva, Michael A.; See, Alfred P.; Essayed, Walid Ibn; Golby, Alexandra J.; Tie, Yanmei

doi:10.1016/j.nicl.2017.12.008

Cited by 122 publications

(97 citation statements)

References 154 publications

(176 reference statements)

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“…Additionally, there are several technical challenges and issues of variability of rs-fMRI that need to also be addressed. These factors may lead to altered and unreliable BOLD effects as seen on the conventional task-based fMRI, such as neurovascular uncoupling and head motion (for a thorough review of these issues, see Silva et al 58 ).…”

Section: Limitationsmentioning

confidence: 99%

Mapping cognitive and emotional networks in neurosurgical patients using resting-state functional magnetic resonance imaging

Catalino

Yao

Green

et al. 2020

Neurosurgical Focus

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Neurosurgery has been at the forefront of a paradigm shift from a localizationist perspective to a network-based approach to brain mapping. Over the last 2 decades, we have seen dramatic improvements in the way we can image the human brain and noninvasively estimate the location of critical functional networks. In certain patients with brain tumors and epilepsy, intraoperative electrical stimulation has revealed direct links between these networks and their function. The focus of these techniques has rightfully been identification and preservation of so-called “eloquent” brain functions (i.e., motor and language), but there is building momentum for more extensive mapping of cognitive and emotional networks. In addition, there is growing interest in mapping these functions in patients with a broad range of neurosurgical diseases. Resting-state functional MRI (rs-fMRI) is a noninvasive imaging modality that is able to measure spontaneous low-frequency blood oxygen level–dependent signal fluctuations at rest to infer neuronal activity. Rs-fMRI may be able to map cognitive and emotional networks for individual patients. In this review, the authors give an overview of the rs-fMRI technique and associated cognitive and emotional resting-state networks, discuss the potential applications of rs-fMRI, and propose future directions for the mapping of cognition and emotion in neurosurgical patients.

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Section: Limitationsmentioning

confidence: 99%

Mapping cognitive and emotional networks in neurosurgical patients using resting-state functional magnetic resonance imaging

Catalino

Yao

Green

et al. 2020

Neurosurgical Focus

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“…For complaints or symptoms currently perceived as purely functional, as well as for early-stage diseases associated with only delayed lesions, functional imaging indeed provides more sensitive tools. Among them, functional MRI (fMRI) based on blood-oxygen-level dependent (BOLD) contrast is an increasingly available method for the research study of brain activity, at rest or during a paradigm of activation, among patients with neurological and psychiatric disorders, and in current clinical practice mostly for presurgical planning in patients presenting with a lesion close to a critically functional brain region [12]. On the other hand, PET and SPECT imaging contribute to identify molecular signature, usually at resting-state, through the targeting of biological processes by specific tracers radiomarked as radiopharmaceuticals [13].…”

Section: Functional Imaging As a Biomarker Of Subjective Complaints?mentioning

confidence: 99%

Functional neuroimaging in patients presenting with somatoform disorders: A model for investigating persisting symptoms after tick bites and post-treatment Lyme disease syndrome?

Guedj

Eldin

Raoult

et al. 2019

Médecine et Maladies Infectieuses

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Approximately 10% of patients with Lyme disease will develop fatigue, musculoskeletal pain, difficulties of concentration or deficits in short-term memory within the 6 months after treatment. This entity has been defined as Post Lyme Disease Syndrome or Post Treatment Lyme Disease Syndrome. The pathophysiology of this syndrome is not known, but neither persistence of the bacterium nor efficiency of antibiotics are currently sustained by the existing literature. In France, the Haut Conseil de Santé Publique has recently define a new entity called "persistent polymorphic semiology after tick bite" allowing to design studies to better understand these subjective manifestations, for which objective biomarkers currently lack. This entity encompasses patients suffering from fatigue and global pain in the months following a tick bite, and can be associated to several subjective symptoms with a major impact on quality of life.In interaction with the model of somatoform disorders, this article proposes a review of functional neuroimaging studies in patients with subjective complaints and discusses possible clinical implications for persisting symptoms after tick bites and Post Treatment Lyme Disease Syndrome.

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“…Image-guided neurosurgery, including presurgical functional mapping with functional magnetic resonance image (fMRI), is increasingly used by neurosurgeons to perform safer, more precise, and less invasive brain surgery (Golby, 2015). Accurate presurgical planning is critical for maximizing tumor removal and maximally preserving eloquent cortices that support critical brain functions, such as motor control and language (Tharin and Golby, 2007;Silva et al, 2018). Presurgical language mapping can facilitate the neurosurgeon's decision to limit the extent of tumor resection in order to preserve function; or give the neurosurgeon more confidence to proceed with tumor removal, particularly when the tumor is in close proximity to classical language regions.…”

Section: Introductionmentioning

confidence: 99%

Sex Effect on Presurgical Language Mapping in Patients With a Brain Tumor

et al. 2020

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Differences between males and females in brain development and in the organization and hemispheric lateralization of brain functions have been described, including in language. Sex differences in language organization may have important implications for language mapping performed to assess, and minimize neurosurgical risk to, language function. This study examined the effect of sex on the activation and functional connectivity of the brain, measured with presurgical functional magnetic resonance imaging (fMRI) language mapping in patients with a brain tumor. We carried out a retrospective analysis of data from neurosurgical patients treated at our institution who met the criteria of pathological diagnosis (malignant brain tumor), tumor location (left hemisphere), and fMRI paradigms [sentence completion (SC); antonym generation (AG); and resting-state fMRI (rs-fMRI)]. Forty-seven patients (22 females, mean age = 56.0 years) were included in the study. Across the SC and AG tasks, females relative to males showed greater activation in limited areas, including the left inferior frontal gyrus classically associated with language. In contrast, males relative to females showed greater activation in extended areas beyond the classic language network, including the supplementary motor area (SMA) and precentral gyrus. The rs-fMRI functional connectivity of the left SMA in the females was stronger with inferior temporal pole (TP) areas, and in the males with several midline areas. The findings are overall consistent with theories of greater reliance on specialized language areas in females relative to males, and generalized brain areas in males relative to females, for language function. Importantly, the findings suggest that sex could affect fMRI language mapping. Thus, considering sex as a variable in presurgical language mapping merits further investigation.

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Challenges and techniques for presurgical brain mapping with functional MRI

Cited by 122 publications

References 154 publications

Mapping cognitive and emotional networks in neurosurgical patients using resting-state functional magnetic resonance imaging

Mapping cognitive and emotional networks in neurosurgical patients using resting-state functional magnetic resonance imaging

Functional neuroimaging in patients presenting with somatoform disorders: A model for investigating persisting symptoms after tick bites and post-treatment Lyme disease syndrome?

Sex Effect on Presurgical Language Mapping in Patients With a Brain Tumor

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