Challenges and Strategies for Endothelializing Decellularized Small‐Diameter Tissue‐Engineered Vessel Grafts
Heng Ding,
Xiaojie Hou,
Zhen Gao
et al.
Abstract:Vascular diseases are the leading cause of ischemic necrosis in tissues and organs, necessitating using vascular grafts to restore blood supply. Currently, small vessels for coronary artery bypass grafts are unavailable in clinical settings. Decellularized small‐diameter tissue‐engineered vessel grafts (SD‐TEVGs) hold significant potential. However, they face challenges, as simple implantation of decellularized SD‐TEVGs in animals leads to thrombosis and calcification due to incomplete endothelialization. Cons… Show more
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