Challenges and Special Aspects of Pulmonary Hypertension in Middle- to Low-Income Regions

Hasan, Babar; Hansmann, Georg; Budts, Werner; Heath, Alexandra; Hoodbhoy, Zahra; Jing, Zhi‐Cheng; Köestenberger, Martin; Meinel, Katharina; Mocumbi, Ana Olga; Radchenko, G.; Sallmon, Hannes; Sliwa, Karen; Kumar, R Krishna; Pcsi,

doi:10.1016/j.jacc.2020.03.047

Cited by 30 publications

(37 citation statements)

References 66 publications

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“…The population in the developing world is about 7 billion vs 1 billion in the developed world. Our speculative calculations and accounting for population numbers, the likelihood to develop pulmonary hypertension is twice than those living in the developed countries 94 .…”

Section: In Summarymentioning

confidence: 92%

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Pulmonary hypertension: From an orphan disease to a global epidemic

Butrous

2020

gcsp

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[No abstract. Showing first paragraph of article]Pulmonary hypertension is a progressive disease characterized by an elevation of pulmonary artery pressure and pulmonary vascular resistance, leading to right ventricular failure and death. It remains a challenging chronic progressive disease, but the current interest and advent of medical therapy in the last 20 years has significantly changed the perception of medical community in this disease. Pulmonary hypertension is not a specific disease; the majority of cases present with other diseases and various pathological processes that affect the pulmonary vasculature, and consequently increase pulmonary pressure and vascular resistance.

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Section: In Summarymentioning

confidence: 92%

“…These registries were supplemented by many other smaller regional registries in middle- to low-Income regions 94 . Collectively, they collected baseline characteristics and clinical outcome data on more than 10,000 patients, with the main emphasis on Group 1 95 .…”

Section: The Epidemiology Of Pulmonary Hypertensionmentioning

confidence: 99%

Pulmonary hypertension: From an orphan disease to a global epidemic

Butrous

2020

gcsp

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“…Excessive hypoxic pulmonary vasoconstriction is generally thought to contribute to marked pulmonary hypertension in sea-level residents with high-altitude pulmonary edema, and in high-altitude residents with chronic mountain sickness or high-altitude pulmonary hypertension [1,2]. Moreover, in chronic mountain sickness patients with slightly elevated resting pulmonary artery pressures compared to apparently healthy high-altitude dwellers, even light-intensity exercise was associated with an accentuated pulmonary artery pressure increase [3,4].…”

Section: Introductionmentioning

confidence: 99%

An Exaggerated Rise in Pulmonary Artery Pressure in a High-Altitude Dweller during the Cold Season

Sydykov

Maripov

Kushubakova

et al. 2021

IJERPH

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Chronic hypoxia-induced sustained pulmonary vasoconstriction and vascular remodeling lead to mild-to-moderate elevation of pulmonary artery pressure in high-altitude residents. However, in some of them, severe pulmonary hypertension may develop. Besides hypoxia, high-altitude residents also face other environmental challenges such as low ambient temperatures. We describe a case of a 49-year-old woman of Kyrgyz ethnicity with abnormally increased pulmonary artery pressure, revealed by Doppler echocardiography. Significantly elevated pulmonary artery pressure was detected in late winter and this was not associated with right ventricular hypertrophy or right ventricular dysfunction. Repeat echocardiography performed in late summer disclosed a significant attenuation of pulmonary artery pressure elevation, with no changes in right ventricular performance parameters. This case illustrates that, in susceptible individuals, long-term cold exposure could induce an abnormal pulmonary artery pressure rise, which can be reversed during warm seasons as in our patient. In certain circumstances, however, additional factors could contribute to a sustained pulmonary artery pressure increase and the development of persistent pulmonary hypertension, which often leads to right heart failure and premature death.

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“…Elevated mean pulmonary artery pressure (mPAP) is the principal hemodynamic criterion for pulmonary hypertension (PH) (1-4)-a condition that is associated with increased clinical risk across a wide spectrum of diseases (4)(5)(6)(7). Since increased mPAP may occur from a diverse number of risk factors and pathways (1,4,5,8), comprehensive clinical phenotyping with accurate cardiopulmonary hemodynamic assessment by cardiac catheterization is needed.…”

Section: Introductionmentioning

confidence: 99%