Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss

Kayyali, Mohammad N.; Wright, Alexander C.; Ramsey, Andrew J.; Brant, Jason A.; Stein, Joel M.; O’Malley, Bert W.; Li, Daqing

doi:10.1016/j.nano.2017.10.004

Cited by 9 publications

(7 citation statements)

References 78 publications

(129 reference statements)

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“…Various animal models, such as zebrafish, frog, birds, and mammals, have been used to investigate the human inner ear function, diseases, and treatment measures because access to human inner ear tissues is strictly limited, and tissue sampling is technically challenging and with irreparable injuries [53]. It is necessary to mention that both mammals and humans do not possess the innate ability to regenerate the lost sensory cells in the cochlea when development is completed [54].…”

Section: Inner Ear and Hearing Lossmentioning

confidence: 99%

“…There are limited numbers of stem cells in the cochlea possessing limited proliferation potential to express the markers of adult stem cells too [55]. Non-invasive procedures, such as computed tomography (CT) scan or magnetic resonance imaging (MRI), cannot provide enough resolution to determine most pathologies of the inner ear [53]. Therefore, transplantation of exogenous MSCs can take advantage of an array of stem cells from various tissue sources [4].…”

Section: Inner Ear and Hearing Lossmentioning

confidence: 99%

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Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Kaboodkhani

Mehrabani

Karimi‐Busheri

2021

JCM

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Otorhinolaryngology enrolls head and neck surgery in various tissues such as ear, nose, and throat (ENT) that govern different activities such as hearing, breathing, smelling, production of vocal sounds, the balance, deglutition, facial animation, air filtration and humidification, and articulation during speech, while absence of these functions can lead to high morbidity and even mortality. Conventional therapies for head and neck damaged tissues include grafts, transplants, and artificial materials, but grafts have limited availability and cause morbidity in the donor site. To improve these limitations, regenerative medicine, as a novel and rapidly growing field, has opened a new therapeutic window in otorhinolaryngology by using cell transplantation to target the healing and replacement of injured tissues. There is a high risk of rejection and tumor formation for transplantation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs) lack these drawbacks. They have easy expansion and antiapoptotic properties with a wide range of healing and aesthetic functions that make them a novel candidate in otorhinolaryngology for craniofacial defects and diseases and hold immense promise for bone tissue healing; even the tissue sources and types of MSCs, the method of cell introduction and their preparation quality can influence the final outcome in the injured tissue. In this review, we demonstrated the anti-inflammatory and immunomodulatory properties of MSCs, from different sources, to be safely used for cell-based therapies in otorhinolaryngology, while their achievements and challenges have been described too.

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Section: Inner Ear and Hearing Lossmentioning

confidence: 99%

Section: Inner Ear and Hearing Lossmentioning

confidence: 99%

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Kaboodkhani

Mehrabani

Karimi‐Busheri

2021

JCM

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“…Additionally, noninvasive imaging techniques do not provide the level of detail needed to study inner ear pathology. 4,33 Organoids overcome these issues, as they are more easily accessible, sustainable, and modifiable, all while more closely recapitulating the human cochlear function.…”

Section: Inner Ear Organoidsmentioning

confidence: 99%

Advancements in Stem Cell Technology and Organoids for the Restoration of Sensorineural Hearing Loss

et al. 2021

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Background Sensorineural hearing loss (SNHL) is a significant cause of morbidity worldwide and currently has no curative treatment. Technological advancements in stem cell therapy have led to numerous studies that examine the generation of otic sensory cells from progenitors to restore inner ear function. Recently, organoids have emerged as a promising technique to further advance the process of creating functional replacement cells after irreversible hearing loss. Organoids are the three-dimensional generation of stem cells in culture to model the tissue organization and cellular components of the inner ear. Organoids have emerged as a promising technique to create functioning cochlear structures in vitro and may provide crucial information for the utilization of stem cells to restore SNHL. Purpose The purpose of this review is to discuss the recent advancements in stem cell-based regenerative therapy for SNHL. Results Recent studies have improved our understanding about the developmental pathways involved in the generation of hair cells and spiral ganglion neurons. However, significant challenges remain in elucidating the molecular interactions and interplay required for stem cells to differentiate and function as otic sensory cells. A few of the challenges encountered with traditional stem cell therapy may be addressed with organoids. Conclusion Stem cell-based regenerative therapy holds a great potential for developing novel treatment modalities for SNHL. Further advancements are needed in addressing the challenges associated with stem cell-based regenerative therapy and promote their translation from bench to bedside.

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“…Access to human inner ear tissues is severely limited since tissue sampling is technically challenging and leads to irreparable damage. Non-invasive clinical imaging techniques, such as computed tomography or MRI, currently do not provide sufficient resolution to determine most pathologies of the inner ear ( Kayyali et al., 2018 ). Pathologies of many human inner ear disorders can currently only be acquired by postmortem examinations.…”

Section: Main Textmentioning

confidence: 99%

Progress in Modeling and Targeting Inner Ear Disorders with Pluripotent Stem Cells

2020

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Sensorineural hearing loss and vestibular dysfunction are caused by damage to neurons and mechanosensitive hair cells, which do not regenerate to any clinically relevant extent in humans. Several protocols have been devised to direct pluripotent stem cells (PSCs) into inner ear hair cells and neurons, which display many properties of their native counterparts. The efficiency, reproducibility, and scalability of these protocols are enhanced by incorporating knowledge of inner ear development. Modeling human diseases in vitro through genetic manipulation of PSCs is already feasible, thereby permitting the elucidation of mechanistic understandings of a wide array of disease etiologies. Early studies on transplantation of PSC-derived otic progenitors have been successful in certain animal models, yet restoration of function and long-term cell survival remain unrealized. Through further research, PSC-based approaches will continue to revolutionize our understanding of inner ear biology and contribute to the development of therapeutic treatments for inner ear disorders.

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Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss

Cited by 9 publications

References 78 publications

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Advancements in Stem Cell Technology and Organoids for the Restoration of Sensorineural Hearing Loss

Progress in Modeling and Targeting Inner Ear Disorders with Pluripotent Stem Cells

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