Challenges and opportunities in biological funneling of heterogeneous and toxic substrates beyond lignin

Borchert, Andrew J.; Henson, William R.; Beckham, Gregg T.

doi:10.1016/j.copbio.2021.06.007

Cited by 43 publications

(25 citation statements)

References 128 publications

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“…Surprisingly, this microbe could also funnel the heterogeneous mixture of aromatic monomers formed by the chemical depolymerization of poplar lignin into PDC. Currently, biological funnelling of other heterogeneous and toxic compounds has also gained essence ( Borchert et al, 2022 ).…”

Section: Methods Of Lignin Depolymerizationmentioning

confidence: 99%

Endophytes in Lignin Valorization: A Novel Approach

Mattoo

Nonzom

2022

Front. Bioeng. Biotechnol.

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Lignin, one of the essential components of lignocellulosic biomass, comprises an abundant renewable aromatic resource on the planet earth. Although 15%––40% of lignocellulose pertains to lignin, its annual valorization rate is less than 2% which raises the concern to harness and/or develop effective technologies for its valorization. The basic hindrance lies in the structural heterogeneity, complexity, and stability of lignin that collectively makes it difficult to depolymerize and yield common products. Recently, microbial delignification, an eco-friendly and cheaper technique, has attracted the attention due to the diverse metabolisms of microbes that can channelize multiple lignin-based products into specific target compounds. Also, endophytes, a fascinating group of microbes residing asymptomatically within the plant tissues, exhibit marvellous lignin deconstruction potential. Apart from novel sources for potent and stable ligninases, endophytes share immense ability of depolymerizing lignin into desired valuable products. Despite their efficacy, ligninolytic studies on endophytes are meagre with incomplete understanding of the pathways involved at the molecular level. In the recent years, improvement of thermochemical methods has received much attention, however, we lagged in exploring the novel microbial groups for their delignification efficiency and optimization of this ability. This review summarizes the currently available knowledge about endophytic delignification potential with special emphasis on underlying mechanism of biological funnelling for the production of valuable products. It also highlights the recent advancements in developing the most intriguing methods to depolymerize lignin. Comparative account of thermochemical and biological techniques is accentuated with special emphasis on biological/microbial degradation. Exploring potent biological agents for delignification and focussing on the basic challenges in enhancing lignin valorization and overcoming them could make this renewable resource a promising tool to accomplish Sustainable Development Goals (SDG’s) which are supposed to be achieved by 2030.

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Section: Methods Of Lignin Depolymerizationmentioning

confidence: 99%

Endophytes in Lignin Valorization: A Novel Approach

Mattoo

Nonzom

2022

Front. Bioeng. Biotechnol.

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“…In general, most industrial biosynthesis processes prefer to use a single engineered microorganism to facilitate the production control. But in a single microbe, there is a competition for cellular resources in different metabolic pathways ( Borchert et al, 2022 ). The application of microbial co-culture systems can reduce these catabolic limitations, improve streams towards desired chemicals, or enhance microbial resistance to toxicity ( Singh et al, 2019 ).…”

Section: Bio-conversion Of Lignin To Lipidsmentioning

confidence: 99%

Recent Biotechnology Advances in Bio-Conversion of Lignin to Lipids by Bacterial Cultures

Wang

Peng

et al. 2022

Front. Chem.

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The complexity and recalcitrance of the lignin structure is a major barrier to its efficient utilization and commercial production of high-value products. In recent years, the “bio-funneling” transformation ability of microorganisms has provided a significant opportunity for lignin conversion and integrated biorefinery. Based on the chemical structure of lignin, this mini-review introduces the recent advances of lignin depolymerization by bacterial strains and the application of microbial lignin degradation in lipids production. Furthermore, the current challenges, future trends and perspectives for microbe-based lignin conversion to lipids are discussed.

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“…To this end, biological funneling is a promising approach for valorizing heterogeneous mixtures. 6,7 This process harnesses microbial metabolism to convert mixtures of compounds to a single product. Some microbes have an impressive capacity to execute convergent chemistries on multiple substrates.…”

Section: Introductionmentioning

confidence: 99%