In Italy, the regeneration of historic centers is a relevant issue in the theoretical debate and practice of urban planning, a discourse which usually adopts strictly constraining approaches and tools directed almost exclusively at the preservation of the traditional characters of historic buildings, neglecting social and economic processes. In particular, the redevelopment of minor historic centers becomes a priority action for the revitalisation of marginal territories affected by the phenomena of depopulation and weakening of the socio-economic structure. The paper focuses on the regional context of Sardinia to investigate methods and criteria for the drafting of planning tools for the redevelopment of minor historic centers, enabling the definition and implementation of strategies in accordance with the objectives and guidelines of the Regional Landscape Plan. With a case study methodology applied to the historic center of Mogoro, the research discusses an innovative and interdisciplinary approach to the definition of flexible regulations to manage the urban regeneration process.