Challenges and opportunities for circRNA identification and delivery

Dong, Jiani; Zeng, Zhuoer; Huang, Ying; Chen, Chuanpin; Zhang, Cheng; Zhu, Qubo

doi:10.1080/10409238.2023.2185764

Cited by 6 publications

(4 citation statements)

References 100 publications

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“…Although advances in surgery and chemotherapy, the overall survival for GC is still not satisfactory [16] . However, with the development of genomic analysis platform, increasing evidence has shown that differentially expressed circRNAs are involved in various diseases and cancers, including GC [17] , [18] , [19] . These circRNAs are also found in exosomes, which can be used as promising biomarkers and play important biological functions in cancers such as GC.…”

Section: Discussionmentioning

confidence: 99%

Exosomal circ50547 as a potential marker and promotor of gastric cancer progression via miR-217/HNF1B axis

Zang,

Wang,

Wang

et al. 2024

Translational Oncology

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Section: Discussionmentioning

confidence: 99%

Exosomal circ50547 as a potential marker and promotor of gastric cancer progression via miR-217/HNF1B axis

Zang,

Wang,

Wang

et al. 2024

Translational Oncology

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“…LncRNAs, acting as sponges, guides, and regulators, influence transcription, chromatin structure, and histone modification, and are crucial in numerous biological processes, including epigenetic regulation, cell differentiation, motility, and apoptosis, thus drawing significant attention in gene regulation research ( Abbasifard et al, 2020 ). CircRNAs, notable for their stable, ring-closed structure ( Dong et al, 2023 ), are rich in MRE and excel as molecular "sponges", effectively countering miRNA-mediated inhibition ( Kristensen et al, 2019 ). Pseudogenes, often disrupted by premature termination codons, frame-shifting mutations, insertions, or deletions, are traditionally regarded as "non-functional", "redundant", or "evolutionary remnants" ( D'Errico et al, 2004 ).…”

Section: Characteristics and Biological Functions Of Cernamentioning

confidence: 99%

The role of competing endogenous RNA network in the development of hepatocellular carcinoma: potential therapeutic targets

Tang,

Li,

Zheng

et al. 2024

Front. Cell Dev. Biol.

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The current situation of hepatocellular carcinoma (HCC) management is challenging due to its high incidence, mortality, recurrence and metastasis. Recent advances in gene genetic and expression regulation have unveiled the significant role of non-coding RNA (ncRNA) in various cancers. This led to the formulation of the competing endogenous RNA (ceRNA) hypothesis, which posits that both coding RNA and ncRNA, containing miRNA response elements (MRE), can share the same miRNA sequence. This results in a competitive network between ncRNAs, such as lncRNA and mRNA, allowing them to regulate each other. Extensive research has highlighted the crucial role of the ceRNA network in HCC development, impacting various cellular processes including proliferation, metastasis, cell death, angiogenesis, tumor microenvironment, organismal immunity, and chemotherapy resistance. Additionally, the ceRNA network, mediated by lncRNA or circRNA, offers potential in early diagnosis and prevention of HCC. Consequently, ceRNAs are emerging as therapeutic targets for HCC. The complexity of these gene networks aligns with the multi-target approach of traditional Chinese medicine (TCM), presenting a novel perspective for TCM in combating HCC. Research is beginning to show that TCM compounds and prescriptions can affect HCC progression through the ceRNA network, inhibiting proliferation and metastasis, and inducing apoptosis. Currently, the lncRNAs TUG1, NEAT1, and CCAT1, along with their associated ceRNA networks, are among the most promising ncRNAs for HCC research. However, this field is still in its infancy, necessitating advanced technology and extensive basic research to fully understand the ceRNA network mechanisms of TCM in HCC treatment.

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“…With the advent of high‐throughput sequencing technologies and bioinformatics analysis, the study of circular RNAs (circRNAs) has exploded in recent years, and thousands of circRNAs have been successfully identified in a variety of cell lines and different species 5 . CircRNAs are a class of non‐coding RNA molecules that do not have a 5′ end cap and a 3′ end tail and forms a loop structure with covalent bonds 6 .…”

Section: Introductionmentioning

confidence: 99%

CircITGA7 regulates malignant phenotypes in bladder cancer cells via targeting miR‐330‐3p/KLF10 axis

Yang,

Wang

2024

The Kaohsiung J of Med Scie

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Bladder cancer (BCa) is one of the common malignancies. Circular RNAs (circRNAs) play regulatory roles in cancer progression. CircITGA7 is a circRNA generated from several exons of ITGA7. The potential role of circITGA7 in BCa remains unknown and needs to be explored. Quantitative real time polymerase chain reaction (qRT‐PCR) was used to assess circITGA7 and miR‐330‐3p expression in BCa tissues and cell lines. Kaplan–Meier analysis was used to evaluate the overall survival of these BCa patients. The biological function of circITGA7 was examined by overexpression of circITGA7 using CCK‐8, EdU, wound‐healing, and Transwell assays. Xenograft assay was performed to further validate the in vitro results. To explore the mechanism of circITGA7, luciferase reporter, RNA pull‐down, fluorescence in situ hybridization (FISH) assays were employed to examine the binding interaction among circITGA7, miR‐330‐3p and kruppel‐like factor 10 (KLF10). Western blot was used to study the protein levels of KLF10.CircITGA7 was downregulated in BCa tissues and cell lines and indicated longer overall survival. Moreover, circITGA7 restricted cell proliferation, migration and invasion of BCa through negatively regulating miR‐330‐3p. The in vivo model showed that circITGA7 influenced the tumor growth. Besides, the overexpression of miR‐330‐3p promoted cell progression by directly targeting KLF10. Mechanistically, circITGA7 inhibited BCa progression by activating KLF10 via targeting miR‐330‐3p.CircITGA7 alleviates BCa cell progression via circITGA7/hsa‐miR‐330‐3p/KLF10 axis, which may provide novel therapeutic targets for BCa.

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Challenges and opportunities for circRNA identification and delivery

Cited by 6 publications

References 100 publications

Exosomal circ50547 as a potential marker and promotor of gastric cancer progression via miR-217/HNF1B axis

Exosomal circ50547 as a potential marker and promotor of gastric cancer progression via miR-217/HNF1B axis

The role of competing endogenous RNA network in the development of hepatocellular carcinoma: potential therapeutic targets

CircITGA7 regulates malignant phenotypes in bladder cancer cells via targeting miR‐330‐3p/KLF10 axis

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