Challenges and Limitations of Clinical Trials on Labor Induction: A Review of the Literature

Viteri, Oscar A.; Sibai, Baha M.

doi:10.1055/s-0038-1676577

Cited by 10 publications

(10 citation statements)

References 93 publications

(172 reference statements)

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“…In addition, drip or injection of induction of labor happens rapidly that the brain can't respond properly to pain in the early stage. Labor induction had been associated with potential risks, such as uterine tachysystole with or without fetal heart rate changes that resulting more contraction of uterine which consequency is mothers feeling more painful (Viteri and Sibai, 2018).…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Dhikr to Intensity of Pain during Active Phase in Mothers Getting Inducing Labour

2020

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Women in labor process with induction are more painful than normal labor that need to applicate an intervention to reduce pain in stage I labor. The purpose of this study is to determine the effect of dhikr towards intensity of pain of labor during the active phase of the mother with labour induction. The study was conducted since May until June 2018 with one group quasi-experimental design. Pain score is measured before and after dhikr using Visual Analog Scale (VAS) every 30 minutes during the active phase of first stage. The mothers who met criteria recruited as the samples. Fifteen muslim mothers who had first labor induction, starting cervical dilatation in 4 cm, gynecoid pelvis and completed cervical dilatation to 10 cm. Statistic analysis performed by ANOVA Repeated Measure test at α = 0.05. The result of the statistical test shows that dhikr has moderate effect of 32.5% to decrease the average score of induction pain at the active phase of first stage (value-p=0.08) after controlled with confounding variables; age and parity. Dhikr had an effect on the decrease of VAS score after 30 minutes intervention (p-value = 0.016), but did not affect the measurement at the end of the first stage of labour (p-value = 0.651). Therefore, dhikr could be used to control pain of induced labor during active phase of first stage. Suggested has teached pregnant women since the third trimester and combined with the other intervention to reduce labour pain.

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Section: Introductionmentioning

confidence: 99%

The Effectiveness of Dhikr to Intensity of Pain during Active Phase in Mothers Getting Inducing Labour

2020

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“…various maternal medical conditions such as chronic hypertension and diabetes [3] . and post-term pregnancy, particularly between 40 and 42 weeks [4].…”

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confidence: 99%

Indications of Labor Induction at Delivery Room of Maternity Teaching Hospital in Erbil City

Noori

Saeed

2021

Erbil j. nurs. midwifery

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Background and objectives: Induction of labour means stimulation of contractions before the birth starts spontaneously, with or without ruptured membranes. The most common indications include oligohydramnios, pre-labour rupture of the membranes, high blood pressure during pregnancy, severe fetal growth restriction, post-term pregnancy, and var-ious maternal medical conditions such as chronic hypertension and diabetes. The aim of the study was to find out the different indications of labour and associated obstetrical factors in a local tertiary hospital. Methods: A cross-sectional study was conducted among 120 parturient women who attended a delivery room in the Maternity Teaching Hospital in Erbil City from the period of 2nd June to 2nd October 2020. After reviewing the literature, a questionnaire was pre-pared to obtain socio-demographic data, data related to reproductive characteristic and data related to the indications for labour induction. The data were analyzed using descrip-tive and inferential statistical approaches. Results: The study included 120 patients with the highest percentage of the patients (49.1%) were 16 to 23 years old and more than half of the sample (51.6%) had a post-term pregnancy, gestational hypertension and pre-eclampsia (15%). There were highly significant statistical differences between parity, gestational age and indication of labour induction, and significant differences between gravidity and antenatal care visits and indi-cations for labour induction. Conclusions: The majority of the sample had a post-term pregnancy of 40 and 42 weeks as an indication for induction of labour followed by gestational hypertension and pre-eclampsia, oligohydramnios and pre-labour rupture of membrane. There was a statistical-ly significant difference between the antenatal care visit and parity with the induction of labour.

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“…In addition, OXT was found in many areas of the brain and functions as a neurotransmitter that modulates a variety of social behaviors such as social cognition, nurturing and social bonding [33][34][35][36][37]. Further, OXT has been shown to have both antidiuretic and vasodilatory effects leading to an increased cerebral, coronary and renal blood flow [38][39][40].…”

Section: Oxytocin-system: Oxytocin Synthesis Release and Its Receptormentioning

confidence: 99%

Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin

Panaro

Benameur

Porro

2020

JCM

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Oxytocin (OXT) is hypothalamic neuropeptide synthetized in the brain by magnocellular and parvo cellular neurons of the paraventricular (PVN), supraoptic (SON) and accessory nuclei (AN) of the hypothalamus. OXT acts in the central and peripheral nervous systems via G-protein-coupled receptors. The classical physiological functions of OXT are uterine contractions, the milk ejection reflex during lactation, penile erection and sexual arousal, but recent studies have demonstrated that OXT may have anti-inflammatory and anti-oxidant properties and regulate immune and anti-inflammatory responses. In the pathogenesis of various neurodegenerative diseases, microglia are present in an active form and release high levels of pro-inflammatory cytokines and chemokines that are implicated in the process of neural injury. A promising treatment for neurodegenerative diseases involves new therapeutic approaches targeting activated microglia. Recent studies have reported that OXT exerts neuroprotective effects through the inhibition of production of pro-inflammatory mediators, and in the development of correct neural circuitry. The focus of this review is to attribute a new important role of OXT in neuroprotection through the microglia–OXT interaction of immature and adult brains. In addition, we analyzed the strategies that could enhance the delivery of OXT in the brain and amplify its positive effects.

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Challenges and Limitations of Clinical Trials on Labor Induction: A Review of the Literature

Cited by 10 publications

References 93 publications

The Effectiveness of Dhikr to Intensity of Pain during Active Phase in Mothers Getting Inducing Labour

The Effectiveness of Dhikr to Intensity of Pain during Active Phase in Mothers Getting Inducing Labour

Indications of Labor Induction at Delivery Room of Maternity Teaching Hospital in Erbil City

Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin

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