Challenge with 17α-ethinylestradiol (EE2) during early development persistently impairs growth, differentiation, and local expression of IGF-I and IGF-II in immune organs of tilapia

Shved, Natallia; Berishvili, Giorgi; Häusermann, Eliane; D'Cotta, Hélèna; Baroiller, Jean‐François; Eppler, Elisabeth

doi:10.1016/j.fsi.2009.02.003

Cited by 50 publications

(33 citation statements)

References 50 publications

(56 reference statements)

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“…This increases plasma levels of free hormones, thus making them available to bind with the ER (Folmar et al 2002;Tollefsen et al 2002Tollefsen et al , 2006. As shown for TBT, aroclor 1260, NP, EE2, or pp 0 DDE, EDCs can also modify the expression of ER and AR genes, thereby potentially affecting the tissue receptivity towards sex-steroids (Sone et al 2005;Vetillard and Bailhache 2006;Zhang and Hu 2008;Mortensen and Arukwe 2009;Shved et al 2009;Yum et al 2010). In addition, these EDCs can also modify the expression of genes that are classically regulated by the receptors.…”

Section: Estrogen-and Androgen-like Endocrine Disrupting Contaminantsmentioning

confidence: 99%

The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review

2011

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During the last decade, a number of studies have shown that, in addition to their classically described reproductive function, estrogens and androgens also regulate the immune system in teleosts. Today, several molecules are known to interfere with the sex-steroid signaling. These chemicals are often referred to as endocrine disrupting contaminants (EDCs). We review the growing evidence that these compounds interfere with the fish immune system. These studies encompass a broad range of approaches from field studies to those at the molecular level. This integrative overview improves our understanding of the various endocrine-disrupting processes triggered by these chemicals. Furthermore, the research also explains why fish that have been exposed to EDCs are more sensitive to pathogens during gametogenesis. In this review, we first discuss the primary actions of sex-steroid-like endocrine disruptors in fish and the specificity of the fish immune system in comparison to mammals. Then, we review the known interactions between the immune system and EDCs and interpret the primary effects of sex steroids (estrogens and androgens) and their related endocrine disruptors on immune modulation. The recent literature suggests that immune parameters may be used as biomarkers of contamination by EDCs. However, caution should be used in the assessment of such immunotoxicity. In particular, more attention should be paid to the specificity of these biomarkers, the external/internal factors influencing the response, and the transduction pathways induced by these molecules in fish. The use of the well-known mammalian models provides a useful guide for future research in fish.

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Section: Estrogen-and Androgen-like Endocrine Disrupting Contaminantsmentioning

confidence: 99%

The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review

2011

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“…In Nile t ilap ia, Rougeot, Kanfitine, Prignon, Genotte, and Mélard (2008) report a reduction of survival of embryos reared for five days in t wo concentrations of EE 2 (100 and 500 µg L -1 ). Shved et al (2009) mention that exposure to EE 2 during early develop ment negatively affects the IGF (insulin-like g rowth factor) system in Nile t ilap ia immune organs and could potentially interfere with the antigen presentation capacity of the immune system, thereby altering the susceptibility to infections during growth and reducing survival. In our work, it was observed that in all EE 2-fed groups there was a lo wer survival rate than in the control g roup.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Juarez-Juarez¹,

Alcántar‐Vázquez²,

Antonio-Estrada³

et al. 2017

Turk. J. Fish. Aquat. Sci.

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Production of YY-males is one of the most important alternatives to the commercial use of hormones for producing monosex populations in the culture of Nile tilapia. One of the final stages of YY-technology is the feminization of the progeny of XY-females in order to obtain YY-females, which when crossed with YY-males makes possible to obtain populations composed of 100% YY-males. The aim of the study was to evaluate the effects of four concentrations (100, 200, 300, 400 mg kg -1 ) of estrogen 17α-ethinylestradiol (EE 2 ) on the sex ratio, growth, condition factor (CV) and gonadosomatic index (GSI) of the progeny of XY-females. Significant differences were observed in wet weight, total length and CV during the experiment; however, final values in EE 2 -treated groups showed not significant differences with control group. The observed proportion of females deviated significantly from the proportion of females expected in the progeny of XY-females in all groups fed EE 2 ; however, only 90% feminization was attained. The group fed 200 mg kg -1 of EE 2 showed a significantly higher value of GSI in comparison to that observed in the control group. By increasing the concentration of EE 2 it is possible to increase the proportion of females without affecting growth or GSI.

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“…The different types of ER show differential binding preferences for ligands and their expression patterns are tissuedependant (Iwanowicz & Ottinger, 2009). Taking into account that ER and AR are widely distributed in immune tissues, including the spleen, liver and anterior kidney (Lynn et al, 2008;Shved et al, 2009;Slater et al, 1995;Todo et al, 1999), the study of endocrine disruptor compounds as potential aquatic pollutants has taken on some importance for fish immunologists. Several anatomical and morphological changes were observed in lymphoid tissues following exposure to xenoestrogens and xenoandrogens.…”

Section: Effects Of Endocrine Disruptors On the Immune Responsementioning

confidence: 99%