Chalcones in Diets

Mah, Siau Hui

doi:10.1007/978-981-13-1745-3_10-1

Cited by 7 publications

(6 citation statements)

References 235 publications

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“…Moreover, the anticancer effect of chalcones in experimental animals has also been shown [ 27 , 28 ]. Additionally, in contrast to “classical” anticancer agents, chalcones are well tolerated as documented in animal as well as clinical studies [ 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Michalková¹,

Mirossay²,

Gazdova³

et al. 2021

Cancers

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Although great progress has been made in the treatment of cancer, the search for new promising molecules with antitumor activity is still one of the greatest challenges in the fight against cancer due to the increasing number of new cases each year. Chalcones (1,3-diphenyl-2-propen-1-one), the precursors of flavonoid synthesis in higher plants, possess a wide spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant, and anticancer. A plethora of molecular mechanisms of action have been documented, including induction of apoptosis, autophagy, or other types of cell death, cell cycle changes, and modulation of several signaling pathways associated with cell survival or death. In addition, blockade of several steps of angiogenesis and proteasome inhibition has also been documented. This review summarizes the basic molecular mechanisms related to the antiproliferative effects of chalcones, focusing on research articles from the years January 2015–February 2021.

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Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Michalková¹,

Mirossay²,

Gazdova³

et al. 2021

Cancers

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“…The parent aglycones and their phase II metabolites could be found in circulation and urine in trace quantities due to limited solubility, and their contribution to small phenolic acid metabolism is largely unexplored. 76 Stilbenoids share their biosynthetic pathway with chalcones; however they are classified as nonflavonoid polyphenols and are best known for resveratrol (grapes), piceatannol (berries, grapes, rhubarb, and passion fruit), and rhapontigenin (rhubarb) at 0.1−2 mg/p/d dietary intake. 77 Resveratrol is also metabolized into piceatannol in humans, 78 while its methylated derivative pterostilbene is more metabolically stable due enhanced tissue distribution and reduced affinity for glucuronidation or sulphation, 79 although physiologic levels of resveratrol achieved with the diet alone had negligible effects on health outcomes.…”

Section: ■ Catabolism Of Other Flavonoids (Quercetin Hesperitin Apige...mentioning

confidence: 99%

All Polyphenols Are Not Created Equal: Exploring the Diversity of Phenolic Metabolites

Vong

Rathinasabapathy

Moncada

et al. 2022

J. Agric. Food Chem.

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Dietary intake of plant polyphenols is significant, and many of them enter a human body as a highly diverse pool of ring-fission phenolic metabolites arising from digestion and microbial catabolism of the parental structures. Difficulty in designing the uniform intervention studies and limited tools calibrated to detect and quantify the inherent complexity of phenolic metabolites hindered efforts to establish and validate protective health effects of these molecules. Here, we highlight the recent findings that describe novel complex downstream metabolite profiles with a particular focus on dihydrophenolic (phenylpropanoic) acids of microbial origin, ingested and phase II-transformed methylated phenolic metabolites (methylated sinks), and small phenolic metabolites derived from the breakdown of different classes of flavonoids, stilbenoids, and tannins. There is a critical need for precise identification of the individual phenolic metabolite signatures originating from different polyphenol groups to enable future translation of these findings into break-through nutritional interventions and dietary guidelines.

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“…Other chalcone constituents such as phloretin-3′,5′-di-C-glucoside present in tomatoes have been reported to possess antioxidant properties [ 96 ]. Panduratin A, boesenbergin A, and pinostrobin chalcone in tomatoes have been reported for their aphrodisiac properties [ 110 ].…”

Section: Naturally Occurring Chalconesmentioning

confidence: 99%

Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

Rudrapal¹,

Khan

Dukhyil

et al. 2021

Molecules

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Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant flavonoids. Chalcones and their natural derivatives are important intermediates of the flavonoid biosynthetic pathway. Plants containing chalcones have been used in traditional medicines since antiquity. Chalcones are basically α,β-unsaturated ketones that exert great diversity in pharmacological activities such as antioxidant, anticancer, antimicrobial, antiviral, antitubercular, antiplasmodial, antileishmanial, immunosuppressive, anti-inflammatory, and so on. This review provides an insight into the chemistry, biosynthesis, and occurrence of chalcones from natural sources, particularly dietary and medicinal plants. Furthermore, the pharmacological, pharmacokinetics, and toxicological aspects of naturally occurring chalcone derivatives are also discussed herein. In view of having tremendous pharmacological potential, chalcone scaffolds/chalcone derivatives and bioflavonoids after subtle chemical modification could serve as a reliable platform for natural products-based drug discovery toward promising drug lead molecules/drug candidates.

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Chalcones in Diets

Cited by 7 publications

References 235 publications

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

All Polyphenols Are Not Created Equal: Exploring the Diversity of Phenolic Metabolites

Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

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