Chalcone Schiff bases disrupt cell membrane integrity of Saccharomyces cerevisiae and Candida albicans cells

Ergüden, Bengü; Lüleci, Hatice Büşra; Ünver, Yasemin

doi:10.1007/s00203-023-03584-y

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Schiff bases have numerous applications including coordination chemistry [23], catalysis [24], chemosensors [25] and intermediates in synthesis [26,27]. They also exhibit a variety of biological applications: antibacterial [28][29][30][31][32][33][34], antifungal [34][35][36], antiviral [37,38], antimalarial [39,40], antituberculosis [41][42][43], anthelmintic [44,45], urease inhibitors [46][47][48], anticancer [49][50][51], antidyslipidemic [52], antidiabetic [53,54], antidepressant Schiff bases are compounds with the structure R'N=CR 2 (R' ̸ = H) [22], traditionally formed in the reaction of alkyl/aryl aldehydes or ketones with primary amines [23]. Many considered them to be synonymous with azomethines (RN=CR 2 , R ̸ = H), both being a particular case of imines (RN=CR 2 , R = H, hydrocarbonyl) [22].…”

Section: Introductionmentioning

confidence: 99%

“…Schiff bases have numerous applications including coordination chemistry [23], catalysis [24], chemosensors [25] and intermediates in synthesis [26,27]. They also exhibit a variety of biological applications: antibacterial [28][29][30][31][32][33][34], antifungal [34][35][36], antiviral [37,38], antimalarial [39,40], antituberculosis [41][42][43], anthelmintic [44,45], urease inhibitors [46][47][48], anticancer [49][50][51], antidyslipidemic [52], antidiabetic [53,54], antidepressant [55][56][57], anticonvulsant [58,59], neurodegenerative disorder treatment [60,61], anti-inflammatory [62] and antioxidant [53,54].…”

Section: Introductionmentioning

confidence: 99%

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Small Schiff Base Molecules—A Possible Strategy to Combat Biofilm-Related Infections

Coandă,

Limban,

Nuță

2024

Antibiotics

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Microorganisms participating in the development of biofilms exhibit heightened resistance to antibiotic treatment, therefore infections involving biofilms have become a problem in recent years as they are more difficult to treat. Consequently, research efforts are directed towards identifying novel molecules that not only possess antimicrobial properties but also demonstrate efficacy against biofilms. While numerous investigations have focused on antimicrobial capabilities of Schiff bases, their potential as antibiofilm agents remains largely unexplored. Thus, the objective of this article is to present a comprehensive overview of the existing scientific literature pertaining to small molecules categorized as Schiff bases with antibiofilm properties. The survey involved querying four databases (Web of Science, ScienceDirect, Scopus and Reaxys). Relevant articles published in the last 10 years were selected and categorized based on the molecular structure into two groups: classical Schiff bases and oximes and hydrazones. Despite the majority of studies indicating a moderate antibiofilm potential of Schiff bases, certain compounds exhibited a noteworthy effect, underscoring the significance of considering this type of molecular modeling when seeking to develop new molecules with antibiofilm effects.

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Section: Introductionmentioning

confidence: 99%

“…Schiff bases have numerous applications including coordination chemistry [23], catalysis [24], chemosensors [25] and intermediates in synthesis [26,27]. They also exhibit a variety of biological applications: antibacterial [28][29][30][31][32][33][34], antifungal [34][35][36], antiviral [37,38], antimalarial [39,40], antituberculosis [41][42][43], anthelmintic [44,45], urease inhibitors [46][47][48], anticancer [49][50][51], antidyslipidemic [52], antidiabetic [53,54], antidepressant [55][56][57], anticonvulsant [58,59], neurodegenerative disorder treatment [60,61], anti-inflammatory [62] and antioxidant [53,54].…”

Section: Introductionmentioning

confidence: 99%