Chagas' disease: study of congenital transmission in cases of acute maternal infection

Abstract

ABSTRACT

Seqüência de transmissões não habituais da infecção chagásica em uma mesma família: transfusional para a mãe e congênita para o filho, de cepa de Trypanosoma cruzi resistente ao tratamento

“…Poucas são as descrições de grávidas em fase aguda, não havendo obrigatoriamente relação entre eles e maior probabilidade de transmissão 9 .…”

Mother-to-Child Transmission of Trypanosoma cruzi

“…Among pregnant T cruzi-infected women in Bolivia, Hermann et al [33] observed increased risk of congenital T cruzi transmission for women with high maternal parasitic load. Rare cases of acute T cruzi infection during pregnancy, characterized by higher parasitemia relative to chronic infection, provide further support, where acute infection was associated with increased risk of congenital infection [35]. In addition, maternal age has also been associated with congenital T cruzi infection; however, study findings have been inconsistent.…”

“…The immunological state of the mother [6,[33][34][35] and fetus [16,[43][44][45][46] may be important for congenital transmission. Hermann et al [33] observed that decreased maternal immune response to parasitic antigens was associated with increased risk of congenital transmission.…”

I Diretriz Latino-Americana para o Diagnóstico e Tratamento da Cardiopatia Chagásica

“…A study carried out in the state of Minas Gerais in 2009 identified a 0.5% prevalence of CD in puerperal women, the most elevated rates being observed in the Northern region of the state, ranging from 2.3% to 23% 382 .…”

“…Therapeutic abortion in chagasic pregnant women is not prescribed, except for extremely severe cases of cardiopathy. Detection and specific treatment are indicated as early as possible for infected children, who usually heal and tolerate the medication well 81,382 . Because newborns maintain the antibodies (IgG class) passively transferred from their mothers up to the fifth or sixth month of life, an early positive serology will not indicate infection until that age.…”