Chagas disease mortality during the coronavirus disease 2019 pandemic: A Brazilian referral center experience

Abstract

study and take responsibility for the integrity of the data and the accuracy of the data analysis. AMH-M was responsible for the study concept. AMH-M, RMS, GMSS, SSX, ASS, ARC, FSNSM, and MFFM were responsible for acquisition, analysis or interpretation of data. AMH-M was responsible for drafting the manuscript. RMS and MFFM were responsible for reviewing the manuscript. MFFM was responsible for statistical analysis. All authors have read and agreed to the published version of the manuscript.

Impact of COVID-19 In-hospital Mortality in Chagas Disease Patients

“…A recent study on mortality in CD and COVID-19 coinfection showed that the presence of comorbidities and their number increased the risk of COVID-19 death ( 13 ). In addition, this study identified deaths of patients with CD followed at INI-Fiocruz, through an active search in the Extrajudicial Portal for consultations on births and deaths of the Judiciary of the state of Rio de Janeiro, who died during the pandemic period.…”

The CUIDA Chagas Project: towards the elimination of congenital transmission of Chagas disease in Bolivia, Brazil, Colombia, and Paraguay

“…Some international strategies and action plans, such as the elimination of mother-to-child transmission (EMTCT) initiative from PAHO and the roadmap for NTDs from the World Health Organization (WHO), have been launched to achieve the elimination of congenital transmission of CD, but many countries do not yet have proper programs in place 4 . Scarcity of diagnostic tools and treatment options, poor treatment adherence, a lack of knowledge and understanding among health providers and people at risk, socio-economic vulnerabilities of endemic areas, and low social mobilization only aggravate the problem 6 , as does the COVID-19 pandemic 10 .…”

“…In order to achieve Outputs 1 and 2, the project will conduct mixed-method implementation research using qualitative and quantitative approaches, which will be implemented in a total of 32 municipalities in Bolivia (10), Brazil (5), Colombia (12) and Paraguay (5) (Figure 2). These municipalities were selected according to public health priorities, ensuring geographically and epidemiologically diverse contexts, with primary health care (PHC) as the central focus of interventions, integrating with existing initiatives such as health and vaccination campaigns and the EMTCT-plus program.…”

Re: “Challenges of addressing neglected tropical diseases amidst the COVID-19 pandemic in Africa: A case of Chagas Disease”

“…Pradhan et al mention that they did a thorough review of articles published in indexed journals, but they do not indicate which period was studied, which databases were consulted or which keywords were used. Recent studies that addressed the Trypanosoma cruzi /covid 19 co-infection were not cited by the authors [ [5] , [6] , [7] ]. These studies suggest that the possible cardiovascular involvement in co-infected patients would not lead to a higher risk of hospitalization and increased mortality, as indicated by Pradhan et al…”