Chagas disease in a recipient of cord blood transplantation

Forés, Rafael; Sanjuán, I; Portero, Francisca; Ruiz, Elena María Villamor; Regidor, C; López‐Vélez, Rogelio; Linares, M.; Gil, Santiago; Ojeda, Emilio; Krsnik, Isabel; Bautista, Guiomar; Vallejo, Carlos; García-Marco, José A.; Fernández, Maribel; Cabrera, José Rafael

doi:10.1038/sj.bmt.1705551

Cited by 52 publications

(21 citation statements)

References 3 publications

(3 reference statements)

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“…This reduction is believed to have been achieved due to the different control initiatives that In the past, Spain has registered cases associated with the three main modes of infection in non-endemic regions: transfusion of blood products [7,8], organ transplantation [17] and vertical transmission [18][19][20] At present, according to the Royal Decree 1088/2005 [4], blood donations from donors who come from areas considered to be at high risk, or with a history of being exposed to high risk, must be tested in order to avoid the use of contaminated blood. The same measures were adopted by the Spanish National Transplant Organization [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…This means that they systematically exclude from donation individuals (i) who come from areas where Chagas disease is endemic, (ii) who were born to mothers from such areas, and (iii) who have received transfusions or have spent prolonged periods of time in such areas (one month or longer in mainly rural areas) [5,6]. In the past 22 years, there have been at least six cases of transfusional Chagas disease in Spain: one of them was reported in Madrid and proved fatal [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Surveillance of Chagas disease in pregnant women in Madrid, Spain, from 2008 to 2010

et al. 2011

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in seven hospitals in the Autonomous Community of Madrid. Serological screening programmes were classified in two main strategies: a selective one (pregnant women from Bolivia) and a universal one (pregnant women from Latin America). A total of 3,839 pregnant women were tested and the overall prevalence was 3.96%. The rate of congenital transmission was 2.6%. The current monitoring programmes have variable coverage ranging between 26% (selective screening) and 100% (universal screening). Monitoring of pregnant women from Latin America only reaches full coverage if universal screening of pregnant women is carried out at any moment of pregnancy, including at delivery. A common national regulation is necessary in order to ensure homogenous implementation of screening.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surveillance of Chagas disease in pregnant women in Madrid, Spain, from 2008 to 2010

et al. 2011

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“…Potential donors born in areas of endemicity or whose mothers were born in such areas as well as patients who have received blood transfusions in at-risk countries are also excluded unless a screening test is found to be negative. In Spain, two cases of infection following a contaminated transfusion have been described (123,382). Villalba et al reported the first fatal case of acute Chagas' disease in Europe, where the donor was identified retrospectively, as the recipient developed a reactivation of Chagas' disease following a cord blood transplant (382).…”

Section: Diagnostic Methods (I) Parasitological Methodsmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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“…The risk from heart transplantation is thought to be higher than that from kidney or liver transplantation (65). One case of transmission through unrelated cord blood transplantation has been reported (104).…”

Section: Transmission Routesmentioning

confidence: 99%

Trypanosoma cruzi and Chagas' Disease in the United States

et al. 2011

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SUMMARY Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi and causes potentially life-threatening disease of the heart and gastrointestinal tract. The southern half of the United States contains enzootic cycles of T. cruzi , involving 11 recognized triatomine vector species. The greatest vector diversity and density occur in the western United States, where woodrats are the most common reservoir; other rodents, raccoons, skunks, and coyotes are also infected with T. cruzi. In the eastern United States, the prevalence of T. cruzi is highest in raccoons, opossums, armadillos, and skunks. A total of 7 autochthonous vector-borne human infections have been reported in Texas, California, Tennessee, and Louisiana; many others are thought to go unrecognized. Nevertheless, most T. cruzi -infected individuals in the United States are immigrants from areas of endemicity in Latin America. Seven transfusion-associated and 6 organ donor-derived T. cruzi infections have been documented in the United States and Canada. As improved control of vector- and blood-borne T. cruzi transmission decreases the burden in countries where the disease is historically endemic and imported Chagas' disease is increasingly recognized outside Latin America, the United States can play an important role in addressing the altered epidemiology of Chagas' disease in the 21st century.

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Chagas disease in a recipient of cord blood transplantation

Cited by 52 publications

References 3 publications

Surveillance of Chagas disease in pregnant women in Madrid, Spain, from 2008 to 2010

Surveillance of Chagas disease in pregnant women in Madrid, Spain, from 2008 to 2010

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Trypanosoma cruzi and Chagas' Disease in the United States

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