Chagas’ disease diagnosis: a multicentric evaluation of Chagas Stat-Pak, a rapid immunochromatographic assay with recombinant proteins of Trypanosoma cruzi

Luquetti, Alejandro O.; Ponce, Carlos; Ponce, Elisa; Esfandiari, Javan; Schijman, Alejandro G.; Revollo, Susana; Áñez, Néstor; Zingales, Bianca; Ramgel-Aldao, Rafael; González, A. Gustavo; Levìn, Mariano J.; Umezawa, Eufrosina Setsu; Silveira, José Franco da

doi:10.1016/s0732-8893(03)00051-8

Cited by 89 publications

(84 citation statements)

References 19 publications

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“…Finally, there are new rapid serological tests that use recombinant proteins in an immunochromatography cassette test with high sensitivity (99%) and specificity (99%), which may be used in emergency situations such as in the hours preceding a transplant procedure (231,296).…”

Section: Diagnostic Methods (I) Parasitological Methodsmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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Section: Diagnostic Methods (I) Parasitological Methodsmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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“…The tests available, such as Stat-Pack® and Imbios®, present great variation in their sensitivity and specificity according to the geographical area, such as Central America, Bolivia and the Amazon region, and they must always be accompanied by a second confirmatory test 60 . Therefore, it is extremely important and necessary to develop a quick test with high sensivity and specificity.…”

Section: Serological Tests For Diagnosis and Cure Verificationmentioning

confidence: 99%

Chagas disease: What is known and what should be improved: a systemic review

Coura

Borges-Pereira

2012

Rev. Soc. Bras. Med. Trop.

117

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This study consists of a broad review on what is known and what should be improved regarding knowledge of Chagas disease, not only through analysis on the main studies published on the topics discussed, but to a large extent based on experience of this subject, acquired over the past 50 years (1961-2011). Among the subjects covered, we highlight the pathogenesis and evolution of infection by Trypanosoma cruzi, drugs in use and new strategies for treating Chagas disease; the serological tests for the diagnosis and the controls of cure the infection; the regional variations in prevalence, morbidity and response to treatment of the disease; the importance of metacyclogenesis of T. cruzi in different species of triatomines and its capacity to transmit Chagas infection; the risks of adaptation of wild triatomines to human dwellings; the morbidity and need for a surveillance and control program for Chagas disease in the Amazon region and the need to prioritize initiatives for controlling Chagas disease in Latin America and Mexico and in non-endemic countries, which is today a major international dilemma. Finally, we raise the need for to create a new initiative for controlling Chagas disease in the Gran Chaco, which involves parts of Argentina, Bolivia and Paraguay.

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“…The serological tests currently in use are indirect immunofluorescence (IIF), indirect hemagglutination (IHA) and enzyme-linked immunosorbent assay (ELISA). They regularly use crude antigenic T. cruzi preparations or semipurified fractions and more recently these tests have used recombinant antigens (Oeleman et al 1998, Luquetti et al 2003, Umezawa et al 2004, Cooley et al 2008. Although many screening methods and sources of antigens have been evaluated, sensitivity and specificity levels have seldom reached 100%.…”

mentioning

confidence: 99%

“…Although many screening methods and sources of antigens have been evaluated, sensitivity and specificity levels have seldom reached 100%. It has been suggested that variability among T. cruzi isolates in conjunction with immunogenetic features of the human host and environmental factors could affect the performance of serological tests (Umezawa et al 1999, Luquetti et al 2003.…”

mentioning

confidence: 99%

Performance levels of four Latin American laboratories for the serodiagnosis of Chagas disease in Mexican sera samples

Luquetti

Espinoza

Martı́nez

et al. 2009

Mem. Inst. Oswaldo Cruz

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Chagas’ disease diagnosis: a multicentric evaluation of Chagas Stat-Pak, a rapid immunochromatographic assay with recombinant proteins of Trypanosoma cruzi

Cited by 89 publications

References 19 publications

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Chagas disease: What is known and what should be improved: a systemic review

Performance levels of four Latin American laboratories for the serodiagnosis of Chagas disease in Mexican sera samples

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