Chagas disease: A Latin American health problem becoming a world health problem

Schmuñis, Gabriel A.; Yadón, Zaida E.

doi:10.1016/j.actatropica.2009.11.003

Cited by 699 publications

(548 citation statements)

References 43 publications

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“…All are stercorarian trypanosomes, with some closely related to the causative agent of Chagas disease, T. cruzi. Chagas disease is no longer confined to South America because of increasing human migration to non-endemic regions [141,142]. The occurrence of trypanosomes related to T. cruzi in Australian native wildlife raises question about the vectorial potential of T. cruzi in Australia, which cannot as yet be answered [137].…”

Section: Wildlife and Zoonosesmentioning

confidence: 99%

The molecular epidemiology of parasite infections: Tools and applications

Lymbery

Thompson

2012

Molecular and Biochemical Parasitology

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Molecular epidemiology, broadly defined, is the application of molecular genetic techniques to the dynamics of disease in a population. In this review, we briefly describe molecular and analytical tools available for molecular epidemiological studies and then provide an overview of how they can be applied to better understand parasitic disease. A range of new molecular tools have been developed in recent years, allowing for the direct examination of parasites from clinical or environmental samples, and providing access to relatively cheap, rapid, high throughput molecular assays. At the same time, new analytical approaches, in particular those derived from coalescent theory, have been developed to provide more robust estimates of evolutionary processes and demographic parameters from multilocus, genotypic data. To date, the primary application of molecular epidemiology has been to provide specific and sensitive identification of parasites and to resolve taxonomic issues, particularly at the species level and below. Population genetic studies have also been used to determine the extent of genetic diversity among populations of parasites and the degree to which this diversity is associated with different host cycles or epidemiologically important phenotypes. Many of these studies have also shed new light on transmission cycles of parasites, particularly the extent to which zoonotic transmission occurs, and on the prevalence and importance of mixed infections with different parasite species or intraspecific variants (polyparasitism). A major challenge, and one which is now being addressed by an increasing number of studies, is to find and utilise genetic markers for complex traits of epidemiological significance, such as drug resistance, zoonotic potential and virulence.

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Section: Wildlife and Zoonosesmentioning

confidence: 99%

The molecular epidemiology of parasite infections: Tools and applications

Lymbery

Thompson

2012

Molecular and Biochemical Parasitology

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“…L'exportation de cas de plus en plus nombreux [30] de maladie de Chagas hors de l'Amérique latine, tout en constituant un problème de santé publique à ne pas négliger, et qu'il faut apprendre à gérer [4,16], ne constitue pas une menace pour les populations d'accueil, qu'elles soient européennes, américaines, australiennes ou autres, à partir du moment où les mesures de prévention nécessaires sont prises au niveau des centres de transfusion sanguine et des services de transplantation. Elle ne doit donc pas être présentée de façon à risquer d'être interprétée comme telle.…”

Section: Introductionunclassified

Non, la maladie de Chagas n’est pas le nouveau sida des Amériques !

Pays

2012

Bull. Soc. Pathol. Exot.

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Résumé Maladie de Chagas et sida ne sauraient être associés, voire confondus sous un même vocable sans distordre la réalité, comme cela a été fait dans un article médical récent intitulé : Chagas disease: "The New HIV/AIDS of the Americas". Si la maladie de Chagas, comme bien d'autres « maladies négligées », présente sur certains points, et en apparence seulement, quelques ressemblances avec le sida, elle s'en différencie en effet sur de nombreux autres qui sont essentiels. Abstract Chagas disease and AIDS: the same terminology cannot be used to associate, let alone confuse, these two diseases with one another without distorting reality, as was done in a recent Mots clés

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“…There are currently more than 300,000 people infected with T. cruzi living in the United States. Most acquired the disease while residing in endemic areas [11]. Although T. cruzi-infected vectors and animals are found in many parts of this country [12], there have only been 5 documented cases of autochthonous (indigenous) transmission in the US [13].…”

Section: Chagas Diseasementioning

confidence: 99%

A Paratransgenic Strategy for the Control of Chagas Disease

Hurwitz

Fieck

Klein

et al. 2012

Psyche: A Journal of Entomology

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Chagas disease results from infection with the parasiteTrypanosoma cruzi. This disease remains a significant cause of morbidity and mortality in central and south America. Chagas disease now exists and is detected worldwide because of human migration. Control of Chagas disease has relied mainly on vector eradication however, the development of insect resistance to pesticides, coupled with cost and adverse health effects of insecticide treatments, has prompted our group to investigate novel methods of transmission control. Our laboratory has been instrumental in the development of the paratransgenic strategy to control vectorial transmission ofT. cruzi. In this paper, we discuss various components of the paratransgenic approach. Specifically, we describe classes of molecules that can serve as effectors, including antimicrobial peptides, endoglucanases, and highly specific single chain antibodies that target surface glycoprotein tags on the surface ofT. cruzi. Furthermore, we address evolving concepts related to field dispersal of engineered bacteria as part of the paratransgenic control strategy and attendant risk assessment evaluation.

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Chagas disease: A Latin American health problem becoming a world health problem

Cited by 699 publications

References 43 publications

The molecular epidemiology of parasite infections: Tools and applications

The molecular epidemiology of parasite infections: Tools and applications

Non, la maladie de Chagas n’est pas le nouveau sida des Amériques !

A Paratransgenic Strategy for the Control of Chagas Disease

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