Chagas Congenital Screening in Switzerland: Processes of Recognition and Knowledge-Sharing

Rapp, Elise

doi:10.1080/01459740.2021.1922900

Cited by 5 publications

(3 citation statements)

References 29 publications

(31 reference statements)

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“…The “economic” studies include cost-benefit analyses of screening programs [ 50 , 51 ]. The five social science [ 52 , 53 , 54 , 55 , 56 ] papers fall within anthropology, sociology and interdisciplinary teams that include anthropologists. To be clear, there are significantly more social science articles on Chagas, but only these five specifically focus on the topic of congenital Chagas or have a significant portion of the article dedicated to congenital Chagas according to our inclusion criteria.…”

Section: Resultsmentioning

confidence: 99%

Knowledge Production on Congenital Chagas Disease across Time, Borders and Disciplines: A Comprehensive Scoping Review

Rapp,

Gold

2023

TropicalMed

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Congenital transmission is a key route of Trypanosoma cruzi infection in Latin America and globally, contributing significantly to the burden of Chagas disease. The interruption of transmission from mother to child has recently become a focus issue. However, the research landscape on congenital Chagas disease remains largely unexplored. The purpose of this scoping review is to assess the production of knowledge on congenital Chagas disease (CCD), aiming to identify research trends and potential gaps. Our initial hypothesis was that the CCD literature overly represents the medical sciences and that there is a need for socio-cultural research on the subject. We conducted a systematic search of publications focusing on congenital Chagas disease in six languages (English, Spanish, Portuguese, French, German and Italian). This comprehensive literature search identified 876 studies that met the inclusion criteria, out of a total of 8893 sources. The relevant literature was analyzed by language, year of publication, discipline, source type and research location. The main outcome of this study has been to prove our hypothesis that there is a scarcity of knowledge produced within the non-biomedical sciences on CCD. This underscores the need for further exploration into the social and structural issues surrounding this disease. Visually clear data concerning congenital Chagas disease produced by this study can contribute to hone in future research efforts and support funding applications. Additionally, this article provides a reference list that other researchers can consult for their own studies.

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Section: Resultsmentioning

confidence: 99%

Knowledge Production on Congenital Chagas Disease across Time, Borders and Disciplines: A Comprehensive Scoping Review

Rapp,

Gold

2023

TropicalMed

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“…Thus far, only local and regional screening programs have been promoted; while Valencia, Galicia, and Catalonia, together with Tuscany, are the only realities where health policies have been adopted to control the congenital transmission of Chagas disease [ 23 , 44 , 45 ]. Other initiatives for congenital Chagas disease screening have been implemented in Bergamo (Italy) and Switzerland [ 30 , 46 ]. Screening programs for congenital Chagas disease prevention have also been promoted at the institutional level in Negrar (Verona), Rome, and Bologna; however, there are no published studies with data from these programs [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

A Questionnaire Integrated with the Digital Medical Record Improved the Coverage of a Control Program for Congenital Chagas Disease in Tuscany, Italy

Barbiero¹,

Mazzi²,

Mantella³

et al. 2023

Microorganisms

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The leading route of Chagas disease transmission in nonendemic countries is congenital. However, policies concerning screening, prevention, and management of congenital Chagas disease are rare in these settings. Since 2012, serological screening for Chagas disease should be provided for pregnant women at risk in Tuscany, Italy according to a Regional resolution. Due to difficulties in the implementation, in November 2019, a checklist aimed at identifying pregnant women at risk for Chagas disease was introduced in digital clinical records at Careggi University Hospital, Florence, Italy. In order to evaluate the effectiveness of the “Chagas checklist”, data about the number of deliveries by women at risk and their screening coverage between 2012 and June 2022 were collected. Out of 1348 deliveries by women at risk, 626 (47%) Trypanosoma cruzi serology tests were performed during the study period. The annual screening coverage increased from an average of 40.3% between 2012 and 2019 to 75.7% between 2020 and June 2022, underlining the big impact of the checklist. Four Chagas disease serological tests out of 626 (0.6%) resulted positive, corresponding to 2 affected women. No cases of congenital transmission occurred. The study showed that a simple digital tool led to a tangible improvement in the coverage of the screening program; its application in a setting where digital charts are available will contribute to the control and elimination of congenital Chagas disease.

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“…The p47rec gene consists of four exons encoding a polypeptide comprising 290 amino acids. P47Rec is characterized by the presence of four repeats of the DM9 domain [15]. This receptor is located mostly on the apical side of midgut epithelial cells immediately below microvilli.…”

Section: Introductionmentioning

confidence: 99%

Coevolutionary analysis of the Pfs47-P47Rec complex: a bioinformatics approach

Ortiz-Morazán,

Moncada,

Escobar

et al. 2023

Preprint

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Background: The ability to predict and comprehend molecular interactions offers significant insights into the biological functions of proteins. The interaction between Pfs47 and P47Rec has attracted increased attention due to their roles in parasite evasion of the mosquito immune system and the concept of geographical coevolution between distinct species. The aims of this study were: (1) to apply a bioinformatics approach to investigate the interaction between Pfs47 and P47Rec proteins, and (2) to identify the potential binding sites, protein orientations, and receptor specificity sites concerning the geographical origins of the vectors and the parasite. Methods: The p47 gene was subjected to sequencing and subsequent analysis in two distinct Anophelesspecies collected in Honduras. In addition, public sequences of the pfs47and p47rec genes were downloaded, which were subsequently filtered to predict functional and structural annotations of the Pfs47-P47Rec complex. Phylogenetic analyses of both proteins were carried out. Results: The findings revealed a pattern of dissemination of anophelines and parasites originating from Africa to other geographical regions. Additionally, the examination of motifs reveals a significant degree of conservation in pfs47, suggesting that Pfs47 might have undergone recent evolutionary development and adaptation. The theory of selectivity of Plasmodium falciparumstrains towards their vectors in diverse geographical regions was supported by structural models and docking analyses. A detailed description of the putative interaction between the Pfs47-P47Rec complex is shown. Conclusions: The findings of this study unveiled coevolutionary trends between P47Rec and Pfs47, which are associated with the process of speciation and the geographical distribution of Anopheles spp and P. falciparum.

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Chagas Congenital Screening in Switzerland: Processes of Recognition and Knowledge-Sharing

Cited by 5 publications

References 29 publications

Knowledge Production on Congenital Chagas Disease across Time, Borders and Disciplines: A Comprehensive Scoping Review

Knowledge Production on Congenital Chagas Disease across Time, Borders and Disciplines: A Comprehensive Scoping Review

A Questionnaire Integrated with the Digital Medical Record Improved the Coverage of a Control Program for Congenital Chagas Disease in Tuscany, Italy

Coevolutionary analysis of the Pfs47-P47Rec complex: a bioinformatics approach

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