CHADS2 and CHA2DS2-VASc scores to predict morbidity and mortality in heart failure patients candidates to cardiac resynchronization therapy

Perini, Alessandro Paoletti; Bartolini, Simone; Pieragnoli, Paolo; Ricciardi, Giuseppe; Perrotta, Laura; Valleggi, Alessandro; Vergaro, Giuseppe; Michelotti, Federica; Boggian, Giulio; Sassone, Biagio; Mascioli, Giosuè; Emdin, M.; Padeletti, Luigi

doi:10.1093/europace/eut190

Cited by 67 publications

(47 citation statements)

References 33 publications

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“…40 Paoletti Perini et al mentioned that CHA 2 DS 2 -VASc score is an independent predictor of major clinical events at 30-month follow-up in patients with HF. 16 Thus, we speculated the hypothesis that higher CHA 2 DS 2 -VASc scores may be associated with worse prognosis in patients with APE.…”

Section: Discussionmentioning

confidence: 99%

“…15 In addition, potential clinical use of CHA 2 DS 2 -VASc score in patients with HF and coronary artery disease (CAD) has been shown. 16,17 Several reports suggest that there is a close association between components of the CHA 2 DS 2 -VASc score and risk of VTE. [18][19][20][21][22][23][24][25] From this point of view, we speculated the hypothesis that higher CHA 2 DS 2 -VASc scores might be associated with risk of mortality in patients with APE.…”

Section: Introductionmentioning

confidence: 99%

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Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Onuk

Karataş

İpek

et al. 2016

Clin Appl Thromb Hemost

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Background: CHA 2 DS 2 -VASc score has been validated in risk prediction for stroke and thromboembolism in patients with atrial fibrillation (AF). Association of CHA 2 DS 2 -VASc score with higher risk of venous thromboembolism and pulmonary embolism (PE) has also been shown. In this study, we investigated the long-term prognostic value of CHA 2 DS 2 -VASc score in patients with acute pulmonary embolism (APE). Methods: Consecutive patients with APE presenting to our emergency department were retrospectively recruited. Patients with AF and who died secondary to causes other than PE were excluded from the study. The CHA 2 DS 2 -VASc score and pulmonary embolism severity index (PESI) were calculated. Results: Two hundred seventy seven participants were included in the study. The mortality rate was 18.7%. Twenty-two cases died within 30 days, and 30 cases died during the follow-up period (median: 13 months). The mean CHA 2 DS 2 -VASc score was significantly higher in dead patients compared to survivors (3.61 + 1.35 vs 1.95 + 1.52, P < .01). In multivariate regression analysis, systolic pulmonary artery pressure (hazard ratio [HR]: 1.03, 95% confidence interval [CI]: 1.01-1.06, P ¼ .02), PESI score (HR: 1.010, 95% CI: 1.004-1.017, P < .01), and CHA 2 DS 2 -VASc score (HR: 1.67, 95% CI: 1.19-2.16, P < .01) were found to be independently correlated with mortality. The patients whose CHA 2 DS 2 -VASc score was between 1 and 3 had 5.67 times and patients whose CHA 2 DS 2 -VASc score was 4 had 16.8 times higher risk of mortality compared to patients with CHA 2 DS 2 -VASc score ¼ 0. Conclusion: Patients with higher CHA 2 DS 2 -VASc scores had higher rates of mortality after APE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Onuk

Karataş

İpek

et al. 2016

Clin Appl Thromb Hemost

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“…HF and AF share common risk‐factors, and the occurrence of either of them may induce the onset of a vicious circle which, in turn, facilitates the manifestation of the other 16. Although the CHADS 2 and CHA 2 DS 2 ‐VASc score series are predictors of stroke in AF patients,3 their predictivity has recently extended beyond their original field as follows: (1) ischemic stroke in patients with coronary artery disease without AF,17 (2) mortality, recurrences of stroke, and major cardiovascular events in stroke patients without AF,18 (3) mortality in stroke survivors with or without AF,19 (4) hospitalization for cardiovascular causes in AF patients,20 and (5) HF hospitalization and cardiac death in HF patients who underwent cardiac resynchronization therapy 21. In addition, it has been recently reported that CHA 2 DS 2 ‐VASc score was associated with not only thromboembolic complications but also mortality in patients with HF 22.…”

Section: Discussionmentioning

confidence: 99%

The CHA₂DS₂‐VASc score as a predictor of high mortality in hospitalized heart failure patients

et al. 2016

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AimsAtrial fibrillation (AF) is common in patients with heart failure (HF). CHA2DS2‐VASc score was originally employed as a risk assessment tool for stroke in patients with AF; however, it has recently been used to predict not only stroke but also various cardiovascular diseases beyond the original AF field. We aimed to verify the CHA2DS2‐VASc score as a risk assessment tool to predict mortality in patients with HF.Methods and ResultsConsecutive 1011 patients admitted for treatment of HF were divided into three groups based on their CHA2DS2‐VASc scores: score 1–3 group (n = 317), score 4–6 group (n = 549) and score 7–9 group (n = 145). Of the 1011 HF patients, 387 (38.3%) had AF. We compared patient characteristics among the three groups and prospectively followed for all‐cause mortality. Although left ventricular ejection fraction was similar among all three groups, all‐cause mortality was higher in the score 4–6 group and score 7–9 group than in the score 1–3 group (37.9 and 29.3% vs. 15.1%, log‐rank P < 0.001). In the multivariable Cox proportional hazard analysis, the CHA2DS2‐VASc score 7–9 was an independent predictor of all‐cause mortality (all HF patients: hazard ratio (HR) 1.822, P = 0.011; HF patients with AF: HR 1.951, P = 0.031; HF patients without AF: HR 2.215, P = 0.033).ConclusionsThe CHA2DS2‐VASc score was an independent predictor of all‐cause mortality in HF patients with or without AF. This comprehensive risk assessment score may help identify HF patients who are at high risk for mortality in HF patient.

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“…Шкала CHA 2 DS 2 -VASc позволяет прогнозировать заболеваемость и смертность у пациентов с сердеч-ной недостаточностью и показаниями для сердечной ресинхронизирующей терапии [27]. Шкалы оценки тяжести внебольничной пневмонии успешно приме-нялись у пациентов с госпитальной пневмонией [28].…”

Section: шкалы могут использоваться в оценке прогноза других заболеванийunclassified

Application of Prediction Scores in Clinical Medicine

Белялов¹

2016

Russ J Cardiol

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CHADS2 and CHA2DS2-VASc scores to predict morbidity and mortality in heart failure patients candidates to cardiac resynchronization therapy

Abstract: In CRT-D patients, pre-implant CHA2DS2-VASc score is an independent predictor of major clinical events at 30-month follow-up.

Cited by 67 publications

References 33 publications

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

The CHA₂DS₂‐VASc score as a predictor of high mortality in hospitalized heart failure patients

Application of Prediction Scores in Clinical Medicine

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CHADS2 and CHA2DS2-VASc scores to predict morbidity and mortality in heart failure patients candidates to cardiac resynchronization therapy

Abstract: In CRT-D patients, pre-implant CHA2DS2-VASc score is an independent predictor of major clinical events at 30-month follow-up.

Cited by 67 publications

References 33 publications

Higher CHA2DS2-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Higher CHA2DS2-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

The CHA2DS2‐VASc score as a predictor of high mortality in hospitalized heart failure patients

Application of Prediction Scores in Clinical Medicine

Contact Info

Product

Resources

About

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

The CHA₂DS₂‐VASc score as a predictor of high mortality in hospitalized heart failure patients