CHADS₂ Score and Risk of New-onset Peripheral Arterial Occlusive Disease in Patients without Atrial Fibrillation: A Nationwide Cohort Study in Taiwan

Abstract

Aim: Although our recent cross-sectional study demonstrated that the CHADS2 score is associated with an ankle-brachial index of 0.9 in patients without atrial fibrillation (AF), the true cause-effect relationship between these parameters remains to be evaluated. Hence, the aim of this study was to investigate whether the CHADS2 score is a useful predictor of new-onset PAOD in non-AF patients. (score 5) and 291 (score 6) patients were studied and followed for the onset of PAOD. We further divided the study patients into four groups: group 1 (score 0), group 2 (score 1-2), group 3 (score 3-4) and group 4 (score 5-6). Results: During the follow-up period of 9.83 0.01 years, 24,775 (3.4%) patients experienced newonset PAOD. The overall incidence of PAOD was 0.6 per 1,000 patient-years. The rate of PAOD increased from 1.8% (group 1) to 18.7% (group 4) (p 0.001). According to a multivariate analysis, groups 2-4 were significantly associated with new-onset PAOD (all p 0.001). In addition, the hazard ratio of each two-point increment in the CHADS2 score for predicting PAOD was 2.51 (p 0.001). Conclusions: The CHADS2 score is a useful predictor of new-onset PAOD in non-AF patients. J Atheroscler Thromb, 2015; 22: 490-498.

Association of Pulse Volume Recording at Ankle with Total and Cardiovascular Mortality in Hemodialysis Patients

“…The presence of PAD impairs quality of life and is associated with a greatly increased risk of major cardiovascular events and death [1]. The risk factors of PAD are old age, the presence of hypertension and diabetes, smoking, and renal insufficiency [2,3]. Among patients with end-stage renal disease on hemodialysis (HD), the prevalence of PAD is high, ranging from 10% to 35% [4,5].…”

“…Among patients with end-stage renal disease on hemodialysis (HD), the prevalence of PAD is high, ranging from 10% to 35% [4,5]. 2…”

Association Between CHADS₂ Score and the Development of Interatrial Block

“…15) Recently, the CHADS2 score has been reported to have a predictive role for outcomes in patients without known AF. [16][17][18][19][20][21] Because congestive heart failure, hypertension, old age, and diabetes mellitus are risk factors for developing IAB, 22,23) and prior stroke might indicate the existence of IAB, 12) it is reasonable to hypothesize that the CHADS2 score has a strong correlation with the development of IAB. However, there is little information available on the association between the CHADS2 score and IAB.…”

Can thromboembolic risk be associated with erectile dysfunction in atrial fibrillation patients?

“…Both scores showed to be predictive not only of thromboembolic stroke risk, but also adverse vascular function, CV and total death in the whole AF population [26][27][28]. Moreover, a predictive value of both scores was confirmed also in patients with other conditions, like ischemic heart disease or in patients with comorbidities also influencing thromboembolic risk profile [29][30][31].…”