CGY-1, a biflavonoid isolated from cardiocrinum giganteum seeds, improves memory deficits by modulating the cholinergic system in scopolamine-treated mice

Zhang, Rongrong; Lin, Ze-Xin; Lu, Xinyi; Xue, Xiao‐Feng; Jiang, Ren‐Wang; Chen, Qu-bo

doi:10.1016/j.biopha.2018.12.100

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…giganteum having antitussive properties. CGY-1 was further reported as a potent agent to improve memory deficit for the treatment of cognitive dysfunction [9]. Similarly, Xia et al [11] reported the isolation of a new biflavonoid, 3 -hydroxyrobustaflavone along with 3 -hydroxyamentoflavone, quercetin, apigenin, and kaempferol with antioxidative activities from the 95% ethanol extract of seeds of C. giganteum var.…”

Section: Resultsmentioning

confidence: 99%

“…Although the Cardiocrinum species have high value as food, medicinal, and ornamental plants [4,6], only a few studies have been performed regarding their chemical constituents. Some previous studies reported the flavonoids from the seeds of C. giganteum [9][10][11] and the starch composition of the bulbs of C. cordatum var. glehnii (F.Schmidt) H.Hara [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Phenolic Acid Derivatives, Flavonoids and Other Bioactive Compounds from the Leaves of Cardiocrinum cordatum (Thunb.) Makino (Liliaceae)

Hori

Watanabe

Devkota

2021

Plants

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Cardiocrinum cordatum (Thunb.) Makino (Family: Liliaceae), commonly known as ‘Ubayuri’, is native to Japan and some islands in the Russian Far East. It has high value as food, medicinal, and ornamental species. The aim of this study was to isolate and characterize the main chemical constituents of the leaves of C. cordatum. A total of 19 compounds, namely caffeic acid (1), caffeic acid methyl ester (2), caffeic acid β-glucopyranosyl ester (3), caffeic acid 4-O-β-glucopyranoside (4), ferulic acid (5), isoferulic acid (6), protocatechuic acid (7), syringic acid (8), 2,6-dimethoxy-p-hydroquinone 1-O-β-glucopyranoside (9), esculetin (10), taxifolin (11), quercetin 3-O-(6-O-α-rhamnopyranosyl)β-glucopyranoside-7-O-β-rhamnopyranoside (12), 2,7-dimethyl-2,4-diene-deca-α,ω-diacid β-glucopyranoside (13), 4-[formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoic acid (14), (3Z)-3-hexenyl β-glucopyranoside (15), tryptophan (16), adenine (17), adenosine (18), and 2-deoxyadenosine (19) were isolated using various chromatographic methods. The structures of isolated compounds were elucidated on the basis of their NMR spectroscopic data. All these compounds were isolated for the first time from the genus Cardiocrinum. Phenolic acid derivatives and flavonoids can be considered as chemotaxonomic markers in the leaves of Cardiocrinum species.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenolic Acid Derivatives, Flavonoids and Other Bioactive Compounds from the Leaves of Cardiocrinum cordatum (Thunb.) Makino (Liliaceae)

Hori

Watanabe

Devkota

2021

Plants

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“…Furthermore, scopolamine leads to increased oxidative stress, elevated inflammation, and blocking of the acetylcholine receptor in the brain [51][52][53]. Oxidative stress causes a significant increase in MDA levels, which is an index of lipid peroxidation, and decreases the expression levels of antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

Sulfated Polysaccharide Isolated from the Nacre of Pearl Oyster Improves Scopolamine-Induced Memory Impairment

et al. 2021

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Pearl and nacre have been used in traditional medicines for treating brain dysfunctions, such as epilepsy, myopia, palpitations and convulsions. We previously showed that a pearl oyster nacre extract improves scopolamine-induced memory impairments using the Y-maze, Banes maze and object recognition tests. In this study, we aimed to isolate the memory-improving substance using ion-exchange column chromatography and reverse-phase column chromatography and elucidate the molecular mechanism underlying its memory-improving activity. The isolated substance was found to be a sulfated polysaccharide with a molecular weight of approximately 750 kDa. Monosaccharide composition analysis showed that it was rich in galactose, glucose, mannose and uronic acid. Furthermore, the mRNA expression levels of oxidative stress, inflammatory response and neuroprotective factors in the cerebral cortex were investigated. Treatment with the polysaccharide increased the expression levels of the antioxidant enzymes Cu, Zn -superoxide dismutase (SOD) and catalase and attenuated the scopolamine-mediated upregulation of the inflammatory cytokines interleukin-1 and interleukin-6. In addition, the polysaccharide suppressed the decrease in the expression levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). These findings strongly suggest that the polysaccharide in the nacre extract mediated its antiamnesic effects by preventing oxidative stress and inflammation and increasing the expression levels of BDNF and NGF.

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“…Choi et al used the peptide of Aβ1-42 to inhibit the aggregation of Aβ1-42 in vitro by thioflavin T fluorescence analysis of biflavonoids (amentoflavone, bilobetin, sequoiaflavone, sotetsuflavone, podocarpuflavone, ginkgetin, isoginkgetin, and sciadopitysin), and found that amentoflavone has the strongest comprehensive strength in inhibiting the formation of Aβ1-42 fibers and reducing the formation of Aβ1-42 fibers among the eight biflavonoids, and it has great potential as a lead compound for treating Alzheimer’s disease [ 295 ]. CGY-1 [ 82 ], GB1, and other gambogic biflavonoids [ 296 ] also have the potential to treat Alzheimer’s disease.…”

Section: Pharmacology Of Biflavonoidsmentioning

confidence: 99%

Proceedings of Chemistry, Pharmacology, Pharmacokinetics and Synthesis of Biflavonoids

Yang

Huang

2021

Molecules

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Biflavonoids, composed of two monoflavonoid residues, occur naturally in angiosperms, bryophytes, ferns, and gymnosperms. More than 592 biflavonoids have been structurally elucidated, and they can be classified into two groups of C-C and C-linear fragments-C, based on whether the linker between the two residues contains an atom. As the linker can be established on two arbitrary rings from different residues, the C-C type contains various subtypes, as does the C-linear fragment-C type. Biflavonoids have a wide range of pharmacological activities, including anti-inflammatory, antioxidant, antibacterial, antiviral, antidiabetic, antitumor, and cytotoxic properties, and they can be applied in Alzheimer’s disease and Parkinson’s disease. This review mainly summarizes the distribution and chemistry of biflavonoids; additionally, their bioactivities, pharmacokinetics, and synthesis are discussed.

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CGY-1, a biflavonoid isolated from cardiocrinum giganteum seeds, improves memory deficits by modulating the cholinergic system in scopolamine-treated mice

Cited by 6 publications

References 26 publications

Phenolic Acid Derivatives, Flavonoids and Other Bioactive Compounds from the Leaves of Cardiocrinum cordatum (Thunb.) Makino (Liliaceae)

Phenolic Acid Derivatives, Flavonoids and Other Bioactive Compounds from the Leaves of Cardiocrinum cordatum (Thunb.) Makino (Liliaceae)

Sulfated Polysaccharide Isolated from the Nacre of Pearl Oyster Improves Scopolamine-Induced Memory Impairment

Proceedings of Chemistry, Pharmacology, Pharmacokinetics and Synthesis of Biflavonoids

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